Agnieszka Grabowiecka

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Born: 11 March 1970, Wroclaw, Poland.

Married: Marcin.

Education: 1995 - M.Sc. - Faculty of Biotechnology, University of Wroclaw, 2003 - Ph.D. - IFaculty of Biotechnology, University of Wroclaw.

Hobby: Tropical freshwater aquarium (South Americal cichlids), cats.

Address: Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland

Phone: +48 71 320 33 02 Fax: +48 71 328 40 64

e-mail: agnieszka.grabowiecka@pwr.wroc.pl


Research interests

Microbial degradation of phosphonic xenobiotics - isolation of new strains capable of utilizing phosphonates, studies on biodegradation pathways. Evaluation of biological activity of novel phosphonic analogues of amino acids and peptides.


Publications

  1. Kozioł, A., Grela, E., Macegoniuk, K.M., Grabowiecka, A., Lochyński, S., Synthesis of nitrogen-containing monoterpenoids with antibacterial activity Nat. Prod. Res., 2019, 1. View at Publisher
  2. Macegoniuk, K.; Grela, E.; Biernat, M.; Psurski, M.; Gościniak, G.; Dziełak, A.; Mucha, A.; Wietrzyk, J.; Berlicki, Ł.; Grabowiecka, A., Aminophosphinates against Helicobacter pylori ureolysis—Biochemical and whole-cell inhibition characteristics PLoS One 2017, 1, 182437. View at Publisher
  3. Macegoniuk, K.; Grela, E.; Palus, J.; Rudzińska-Szostak, E.; Grabowiecka, A.; Biernat, M.; Berlicki, Ł., 1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors. J. Med. Chem. 2016, 59, 8125. View at Publisher
  4. Grela, E.; Dziełak, A.; Szydowska, K.; Mucha, A.; Kafarski, P.; Grabowiecka, A.M., Whole-cell Proteus mirabilis urease inhibition by aminophosphinates for the control of struvite formation. J. Med. Microbiol. 2016, 65, 1123. View at Publisher
  5. Ząbek, A.; Nagaj, J.; Grabowiecka, A.; Dworniczek, E.; Nawrot, U.; Młynarz, P.; Jezowska-Bojczuk, M., Activity of fluconazole and its Cu(II) complex towards Candida species Med. Chem. Res. 2014, 1. View at Publisher
  6. Berlicki, Ł.; Bochno, M.; Grabowiecka, A.; Białas, A.; Kosikowska, P.; Kafarski, P., N-Substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases. Amino Acids 2012, 42, 1937. View at Publisher
  7. Vassiliou, S.; Kosikowska, P.; Grabowiecka, A.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Computer-aided optimization of phosphinic inhibitors of bacterial ureases. J. Med. Chem. 2010, 53, 5597. View at Publisher
  8. Vassiliou, S.; Grabowiecka, A.; Kosikowska, P.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Design, synthesis and evaluation of novel organophosphorus inhibitors of bacterial ureases. J. Med. Chem. 2008, 51, 5736. View at Publisher
  9. Klimek-Ochab, M.; Obojska, A.; Picco, A.M.; Lejczak, B., Isolation and characterization of two new microbial strains capable of degradation of the naturally occurring organophosphonate - ciliatine. Biodegradation 2007, 18, 223.
  10. Forlani, G.; Obojska, A.; Berlicki, Ł.; Kafarski, P., Phosphinothricin Analogues as Inhibitors of Plant Glutamine Synthetases. J. Agric. Food Chem. 2006, 54, 796. View at Publisher
  11. Berlicki, Ł.; Obojska, A.; Forlani, G.; Kafarski, P., Design, Synthesis, and Activity of Analogues of Phosphinothricin as Inhibitors of Glutamine Synthetase. J. Med. Chem. 2005, 48, 6340. View at Publisher
  12. Lejczak, B.; Wojtasek, H.; Berlicki, Ł.; Forlani, G.; Obojska, A.; Drąg. M.; Gąsowska, B.; Grembecka, J.; Olechnowicz. D., Design, Synthesis and Evaluation of Environmentally Friendly Herbicides. Pol. J. Environ. Stud. 2005, 14, 64.
  13. Obojska, A.; Berlicki, Ł.; Kafarski, P.; Lejczak, B.; Chicca, M.; Forlani, G., Herbicidal Pyridyl Derivatives of Aminomethylene-bisphosphonic Acid Inhibit Plant Glutamine Synthetase. J. Agric. Food. Chem. 2004, 52, 3337. View at Publisher
  14. Obojska, A.; Lejczak, B., Utilisation of structurally diverse organophosphonates by Streptomycetes. Appl. Biochem. Microbiol. 2003, 62, 557.
  15. Obojska, A.; Ternan, N.G.; Lejczak, B.; Kafarski, P.; McMullan, G., Organophosphonate utilization by the thermophile Geobacillus caldoxylosilyticus T20. Appl. Env. Microbiol. 2002, 68, 2081.
  16. Obojska, A.; Lejczak, B.; Kubrak, M., Degradation of phosphonates by streptomycete isolates. Appl. Biochem. Microbiol. 1999, 51, 872.