Agnieszka Grabowiecka

From Bioorganic
Jump to: navigation, search
Grabowiecka.jpg

Born: 11 March 1970, Wroclaw, Poland.

Married: Marcin.

Education: 1995 - M.Sc. - Faculty of Biotechnology, University of Wroclaw, 2003 - Ph.D. - IFaculty of Biotechnology, University of Wroclaw.

Hobby: Tropical freshwater aquarium (South Americal cichlids), cats.

Address: Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland

Phone: +48 71 320 33 02 Fax: +48 71 328 40 64

e-mail: agnieszka.grabowiecka@pwr.wroc.pl


Research interests

Microbial degradation of phosphonic xenobiotics - isolation of new strains capable of utilizing phosphonates, studies on biodegradation pathways. Evaluation of biological activity of novel phosphonic analogues of amino acids and peptides.


Publications

  1. Macegoniuk, K.; Grela, E.; Biernat, M.; Psurski, M.; Gościniak, G.; Dziełak, A.; Mucha, A.; Wietrzyk, J.; Berlicki, Ł.; Grabowiecka, A., Aminophosphinates against Helicobacter pylori ureolysis—Biochemical and whole-cell inhibition characteristics PLoS One 2017, 1, 182437. View at Publisher
  2. Macegoniuk, K.; Grela, E.; Palus, J.; Rudzińska-Szostak, E.; Grabowiecka, A.; Biernat, M.; Berlicki, Ł., 1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors. J. Med. Chem. 2016, 59, 8125. View at Publisher
  3. Grela, E.; Dziełak, A.; Szydowska, K.; Mucha, A.; Kafarski, P.; Grabowiecka, A.M., Whole-cell Proteus mirabilis urease inhibition by aminophosphinates for the control of struvite formation. J. Med. Microbiol. 2016, 65, 1123. View at Publisher
  4. Ząbek, A.; Nagaj, J.; Grabowiecka, A.; Dworniczek, E.; Nawrot, U.; Młynarz, P.; Jezowska-Bojczuk, M., Activity of fluconazole and its Cu(II) complex towards Candida species Med. Chem. Res. 2014, 1. View at Publisher
  5. Berlicki, Ł.; Bochno, M.; Grabowiecka, A.; Białas, A.; Kosikowska, P.; Kafarski, P., N-Substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases. Amino Acids 2012, 42, 1937. View at Publisher
  6. Vassiliou, S.; Kosikowska, P.; Grabowiecka, A.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Computer-aided optimization of phosphinic inhibitors of bacterial ureases. J. Med. Chem. 2010, 53, 5597. View at Publisher
  7. Vassiliou, S.; Grabowiecka, A.; Kosikowska, P.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Design, synthesis and evaluation of novel organophosphorus inhibitors of bacterial ureases. J. Med. Chem. 2008, 51, 5736. View at Publisher
  8. Klimek-Ochab, M.; Obojska, A.; Picco, A.M.; Lejczak, B., Isolation and characterization of two new microbial strains capable of degradation of the naturally occurring organophosphonate - ciliatine. Biodegradation 2007, 18, 223.
  9. Forlani, G.; Obojska, A.; Berlicki, Ł.; Kafarski, P., Phosphinothricin Analogues as Inhibitors of Plant Glutamine Synthetases. J. Agric. Food Chem. 2006, 54, 796. View at Publisher
  10. Berlicki, Ł.; Obojska, A.; Forlani, G.; Kafarski, P., Design, Synthesis, and Activity of Analogues of Phosphinothricin as Inhibitors of Glutamine Synthetase. J. Med. Chem. 2005, 48, 6340. View at Publisher
  11. Lejczak, B.; Wojtasek, H.; Berlicki, Ł.; Forlani, G.; Obojska, A.; Drąg. M.; Gąsowska, B.; Grembecka, J.; Olechnowicz. D., Design, Synthesis and Evaluation of Environmentally Friendly Herbicides. Pol. J. Environ. Stud. 2005, 14, 64.
  12. Obojska, A.; Berlicki, Ł.; Kafarski, P.; Lejczak, B.; Chicca, M.; Forlani, G., Herbicidal Pyridyl Derivatives of Aminomethylene-bisphosphonic Acid Inhibit Plant Glutamine Synthetase. J. Agric. Food. Chem. 2004, 52, 3337. View at Publisher
  13. Obojska, A.; Lejczak, B., Utilisation of structurally diverse organophosphonates by Streptomycetes. Appl. Biochem. Microbiol. 2003, 62, 557.
  14. Obojska, A.; Ternan, N.G.; Lejczak, B.; Kafarski, P.; McMullan, G., Organophosphonate utilization by the thermophile Geobacillus caldoxylosilyticus T20. Appl. Env. Microbiol. 2002, 68, 2081.
  15. Obojska, A.; Lejczak, B.; Kubrak, M., Degradation of phosphonates by streptomycete isolates. Appl. Biochem. Microbiol. 1999, 51, 872.