Ewa Żymańczyk-Duda

From Bioorganic
Jump to: navigation, search
Zymanczyk.jpg

Born: 06.07.19..

One child, son.

Hobby: Skiing, mountain climbing, books, movies.

e-mail: ewa.zymanczyk-duda@pwr.wroc.pl

Education:

1990 - Master of Science in Biotechnology.

1995 - PhD in Chemistry.

2008 - Assistant Professor

Research interests

Application of biocatalysts: whole microbial cells (fungal, bacterial) and puryfied enzymes for bioconversion of xenobiotics into the chiral products of define absolute configuration and of known or possible biological activity. Such compounds are considered as therapeutics agents or as chiral building blocks for further synthesis.

Current research

1. Biocatalyzed dessymetrization of hydroxy- and keto phosphonates (via reduction or oxidation - depending on the substrate structure) 2. Biocatalyzed conversion of organophosphorus compounds with one or two stereogenic centers (located on carbon and phosphorus atoms) 3. Engeneering of the biotransformation conditions in order to maximise the effectiveness of the processes and to control the stereo-direction of the bioconversion. 4. Biocatalysts engineering (permeabilization, lyophilization, immobilization)to adapt them to particular biological conversions. 5. Biocatalyzed synthesis of antioxidants and photoprotectors via modyfication of natural compounds of plants origin. 6. Scaling up the selected bioprocesses.

Selected Publications

  1. Żymańczyk-Duda E, Kozyra K, Brzezińska-Rodak M, Klimek-Ochab M, Baker’s yeasts driven synthesis of enantiomers of ethyl 1-hydroxy-1-(3,4-dimethoxyphenyl)methane(P-phenyl)phosphinate - possible organophosphorus CDA’s Journal of Molecular Catalysis. B, Enzymatic 2017, 1. View at Publisher
  2. Górak Monika, Żymańczyk-Duda Ewa, Reductive activity of free and immobilized cells of cyanobacteria toward oxophosphonates - comparative study. Journal of Applied Phycology 2017, 29, 245.
  3. Żymańczyk-Duda Ewa, Microbial bioconversions of biologically active P-C compounds: scope and limitations of scaling-up. Journal of Biotechnology and Biomaterials 2017, 7, 49.
  4. Kmiecik Natalia, Żymańczyk-Duda Ewa, Enantio convergent biotransformation of O,O-dimethyl-4-oxoazetidin-2-ylphosphonate using fungal cells of Penicillium minioluteum and purified enzymes. Bioorganic Chemistry 2017, 71, 81.
  5. Ewa Żymańczyk-Duda, Małgorzata Brzezińska-Rodak, Magdalena Klimek-Ochab, Maciej Duda, Biochemistry - Knowledge to Practical Applications - Examples Biochemstry ISBN: 978-0-9971499-2-0 2017, 1. View at Publisher
  6. Majewska, P.; Serafin, M., Klimek-Ochab, M.; Brzezińska-Rodak, M.; Żymańczyk-Duda, E., Lipases and whole cell biotransformations of 2-hydroxy-2-(ethoxyphenylphosphinyl)acetic acid and its ester Bioorg. Chem. 2016, 66, 21. View at Publisher
  7. Brzezińska-Rodak, M.; Klimek-Ochab, M.; Żymańczyk-Duda, E., Enzyme-mediated protoplast formation of Cuninghamella echinulata – preliminary studies BioTechnologia 2016, 97, 27.
  8. Górak, M.; Żymańczyk-Duda, E., Reductive activity of free and immobilized cells of cyanobacteria toward oxophosphonates—comparative study J. Appl. Phycol. 2016, 1. View at Publisher
  9. Zymanczyk-Duda, E.; Brzezinska-Rodak, M.; Kozyra, K.; Klimek-Ochab, M., Fungal Platform for Direct Chiral Phosphonic Building Blocks Production. Closer Look on Conversion Pathway Appl. Biochem. Biotechnol. 2015, 175, 1403. View at Publisher
  10. Górak, M.; Żymańczyk-Duda, E., Application of cyanobacteria for chiral phosphonate synthesis. Green Chem. 2015, 17, 4570. View at Publisher
  11. Szmigiel, B.; Żymańczyk-Duda, E.; Lochyński, S., Procedura zabiegowa eksfoliacji z zastosowaniem hydroksykwasów. Pol. J. Cosmet. 2015, 18, 119.
  12. Górak, M.; Serafin, M.; Klimek-Ochab, M.; Żymańczyk-Duda, E., Bioocatalitic transformation of epoxy- and vinylphosphonates Chemik 2015, 69, 273.
  13. Klimek-Ochab, M.; Mucha, A.; Żymań„czyk-Duda, E, 2-Aminoethylphosphonate Utilization by the Cold-Adapted Geomyces pannorum P11 Strain Curr. Microbiol. 2014, 68, 330. View at Publisher
  14. Serafin, M.; Żymańczyk-Duda, E., Kinetic resolution of racemic mixture of 2-butyryloxy- 2-(ethoxy-P-phenylphosphinyl)acetic acid by fungi Penicillium oxalicum Chemik 2014, 68, 776.
  15. Monika GĂłrak, Ewa Ĺťymańczyk-Duda, Sposób biokalitycznego otrzymywania (S)-2-hydroksy-2-fenyloetanofosfonianu dietylu. zgłoszenie patentowe P410414 2014, 1.
  16. Monika GĂłrak, Ewa Ĺťymańczyk-Duda, Biokatalityczny sposób otrzymywania (S)-2-hydroksy-2-fenyloetanofosfonianu dietylu. zgłoszenie patentowe P408430 2014, 1.
  17. Monika Górak, Ewa Żymańczyk-Duda, Application of cyanobacteria as biocatalysts for the reduction of diethyl 2-oxopropylphosphonate CHEMIK 2014, 68, 123.
  18. Kinga Kozyra*, Magdalena Klimek-Ochab, Małgorzata Brzezińska-Rodak, Ewa Ĺťymańczyk-Duda, Direct determination of enantiomeric enrichment of chiral, underivatized aminophosphonic acids – useful for enantioselective bioconversion results evaluation Central European Journal of Chemistry 2013, 11, 1542.
  19. Natalia Kmiecik,Magdalena Klimek-Ochab,Małgorzata Brzezińska-Rodak, PaulinaMajewska, and Ewa Żymańczyk-Duda, Chiral Phosphinate Degradation by the Fusarium Species: Scope and Limitation of the Process Biotechnology Research International 2013, 2013, 1.
  20. Kinga Kozyra∗, Małgorzata Brzezińska-Rodak, Magdalena Klimek-Ochab, Ewa Żymańczyk-Duda, Biocatalyzed kinetic resolution of racemic mixtures of chiral alpha-aminophosphonic acids Journal of Molecular Catalysis B: Enzymatic 2013, 91, 32.
  21. MONIKA GÓRAK*, MAŁGORZATA BRZEZIŃSKA-RODAK, MAGDALENA KLIMEK-OCHAB, EWA ŻYMAŃCZYK-DUDA, Amino acid mineralization by Serratia marcescens BioTechnologia: Journal of Biotechnology, Computational Biology and Bionanotechnology 2013, 94, 269.
  22. Żymańczyk-Duda, E.; Klimek-Ochab, M., Stereoselective Biotransformations as an Effective Tool for the Synthesis of Chiral Compounds with P-C Bond - Scope and Limitations of the Methods. Curr. Org. Chem. 2012, 16, 1408.
  23. Brzezińska-Rodak, M.; Klimek-Ochab, M.; Żymańczyk-Duda, E., Biocatalyzed synthesis of chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethanephosphonate. Practical methods for biocatalysis and biotransformations 2 2012, 247. View at Publisher
  24. Brzeziń„ska-Rodak, M.; Klimek-Ochab, M.; Żymań„czyk-Duda E.; Kafarski, P., Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid Molecules 2011, 16, 5896. View at Publisher
  25. Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Klimek-Ochab, M.; Lejczak, B., Application of the Beauveria bassiana Strain for the Enantioselective Oxidation of the Diethyl 1-Hydroxy-1-Phenylmethanephosphonate Curr. Microbiol. 2011, 62, 1168. View at Publisher
  26. Klimek-Ochab, M.; Brzeziń„ska-Rodak, M.; Żymań„czyk-Duda, E.; Lejczak, B.; Kafarski, P., Comparative study of fungal cell disruption—scope and limitations of the methods. Folia Microbiol. 2011, 56, 469. View at Publisher
  27. Brzezińska-Rodak, M.; Żymańczyk-Duda, E.; Klimek-Ochab, M.; Lejczak, B., Fungal Cells Permeabilization as a Convenient Tool of Bioreduction Enantioselectivity Control Pol. J. Chem. 2009, 83, 2113.
  28. Żymańczyk-Duda, E.; Brzeziń„ska-Rodak, M.; Klimek-Ochab, M.; Latajka, R.; Kafarski, P.; Lejczak, B., Chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethylphosphonate as a valuable product of microbial biotransformation of diethyl 2-oxo-2-phenylethylphosphonate J. Mol. Cat. B 2008, 52, 74.
  29. Klimek-Ochab, M.; Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Majewska, P.; Lejczak, B., Effective fungal catalyzed synthesis of P-chiral organophosphorus compounds. Tetrahedron: Asymmetry 2008, 19, 450. View at Publisher
  30. Ewa Żymańczyk-Duda, Biocatalyzed reactions in optically active phosphonates synthesis. Phosphorus, Sulfur, Silicon and the Related Elements 2008, 183, 1.
  31. Brzezińska-Rodak, M.; Żymańczyk-Duda, E.; Klimek-Ochab, M.; Lejczak, B., Biocatalytical synthesis and further determination of the absolute configuration of diethyl of (R)-2-hydroxybutylphosphonate Pol. J. Chem. 2007, 81, 1911.
  32. Brzezinska-Rodak, M.; Zymanczyk-Duda, E.; Klimek-Ochab, M.; Kafarski, P.; Lejczak, B., A simple and green procedure for the microbial effective synthesis of 1-phenylethyl alcohol in both enantiomeric forms. Biotech. Lett. 2006, 28, 511.
  33. Żymańczyk-Duda, E.; Klimek-Ochab, M.; Kafarski, P.; Lejczak, B., Stereochemical control of biocatalytic asymmetric reduction of diethyl 2-oxopropylphosphonate employing yeasts. J. Organomet. Chem. 2005, 690, 2593.
  34. Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Lejczak, B., Stereochemical control of asymmetric hydrogen transfer employing five different kinds of fungi in anhydrous hexane. Enzyme Microbiol. Tech. 2004, 34, 578.
  35. Brzezińska-Rodak, M.; Żymańczyk-Duda, E.; Kafarski, P.; Lejczak, B., Application of fungi as biocatalysts for the reduction of diethyl 1-oxoalkylphosphonates in anhydrous hexane. Biotech. Prog. 2002, 18, 1287.
  36. Gancarz, R.; Latajka, R.; Maluszek, B.; Żymańczyk-Duda, E.; Kafarski, P. , Hydrogen bonding in diethyl 2-hydroxypropylphosphonate - an example of equilibrium between intramolecular and intermolecular bonding. Magn. Res. Chem. 2000, 38, 197.
  37. Ĺťymańczyk-Duda, E.; Kafarski, P.; Lejczak, B., Reductive biotransformation of diethyl beta-, gamma- and delta-oxoalkylphosphonates by cells of baker’s yeast Enzyme Microb. Technol. 2000, 26, 265.
  38. Żymańczyk-Duda, E.; Lejczak, B.; Kafarski, P., Esterification of phosphonic and phosphinic acids analogues of glutamic and aspartic acids with ethyl orthoformate - scope and limitations of the method Phosphorus, Sulfur, Silicon 1996, 112, 47.
  39. Żymańczyk-Duda Ewa, Skwarczyński mariusz, Lejczak Barbara, Kafarski Paweł, Accurate assay of enantiopurity of 1-hydroxy- and 2-hydroxyalklphosphonates esters Tetrahedron:Asymmetry 1996, 7, 1277.
  40. Żymańczyk-Duda Ewa, Lejczak Barbara, Kafarski Paweł, Esterification of phosphonic and phosphinic acids analogues of glutamic and aspartic acids with ethyl orthoformate - scope and limitations of the method Phosphorus, Sulfur and Silicon 1996, 112, 47.
  41. Żymańczyk-Duda Ewa, Lejczak Barbara, Kafarski Paweł, Enantioselective reduction of diethyl 2-oxoalkylphosphonates by baker's yeast. Tetrahedron 1995, 51, 11809.