Katarzyna Hałdys

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Born: 18.09.1989, Opole

Hobby: rollerblading, theater, board games, crime novels

Email: katarzyna.haldys@pwr.edu.pl

Phone: +48 71 320 2461


Education

2015 – present - PhD studies in Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology. Current research: synthesis and investigations of interactions of low molecular weight compounds with tyrosinase. Supervisor: dr. hab. Rafał Latajka, prof. PWr

2012 - 2014 - MSc in Environmental Biotechnology, Faculty of Chemistry, Wroclaw University of Science and Technology. Thesis title: ‘Investigations of interactions of phosphoroorganic compounds with tyrosinase‘. Supervisor: dr. hab. Rafał Latajka, prof. PWr

2012 - 2013 - MSc in Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology. Thesis title: ‘Investigations of interactions of tyrosinase with its potential, low molecular weight inhibitors‘. Supervisor: dr. hab. Rafał Latajka, prof. PWr

2008 - 2012 - BSc in Biotechnology, Faculty of Chemistry, Wroclaw University of Science and Technology. Thesis title: ‘Applications of spectrofluorimetry in enzyme – inhibitor investigations – literature studies‘. Supervisor: dr. hab. Rafał Latajka, prof. PWr


Internships

2016.10 - 2017.01 - Scientific Internship - Organic Chemistry Laboratory, University of Basque Country, Vitoria-Gasteiz (Spain). Project title: ‘Synthesis of α-aminophosphorus derivatives as inhibitors of tyrosinase’. (KNOW – The Leading National research Center)

2015.02 - 2014.11 – Postgraduate Internship – Molecular Biology Laboratory, Leibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben (Germany) Project title : ‘Analysis of cutinase transcription factors in yeast’. (ERASMUS +)

2014.07 - 2014.09 - Internship – Physical Laboratory (R&D), 3M Poland, Wrocław, (Poland). Project: ‘Bionanomaterials: BioNaM – the new interdisciplinary doctoral studies and internship program for students on I, II and III degree of education’.


Publications

  • E. Wolińska, K. Hałdys, J. Góra, T. K. Olszewski, B. Boduszek, R. Latajka, Phosphonic and phosphinic acid derivatives as novel tyrosinase inhibitors: Kinetic studies and molecular docking, Chem. Biodivers. - 2019, DOI
  • K. Hałdys, R. Latajka, Thiosemicarbazones with tyrosinase inhibitory activity, Med. Chem. Commun. 2019, 10, 378-389
  • K. Hałdys, W. Goldeman, M. Jewgiński, E. Wolińska, N. Anger, J. Rossowska, R. Latajka, Inhibitory properties of aromatic thiosemicarbazones on mushroom tyrosinase: synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis inhibition, Bioorg. Chem. 2018, 81, 577-586.


Conference communications

Oral presentations:

  • Hałdys Katarzyna, Goldeman Waldemar, Latajka Rafał: Thiosemicarbazones as New Tyrosinase Inhibitors. XIV Ogólnopolskie Seminarium dla Doktorantów ‘Na pograniczu chemii i biologii’, 22 - 25 May 2016, Karpacz, Poland
  • Hałdys Katarzyna, Goldeman Waldemar, Latajka Rafał: Inhibition kinetics of aryl thiosemicarbazone derivatives on mushroom tyrosinase. BIO 2016 - 2nd Congress of Polish Biochemistry,Cell biology, Biotechnology and Bioinformatics, 13-16 September 2016, Wroclaw, Poland
  • Hałdys Katarzyna, Goldeman Waldemar, Jewgiński Michał, De Los Santos Jesus M., Latajka Rafał: Synthesis and Kinetic Studies of Novel Low-Molecular Weight Inhibitors of Tyrosinase. XV Ogólnopolskie Seminarium dla Doktorantów ‘Na pograniczu chemii i biologii’, 21 - 24 May 2017, Karpacz, Poland.
  • Hałdys Katarzyna, Goldeman Waldemar, Jewgiński Michał, Latajka Rafał: Thiosemicarbazones as Novel Tyrosinase Inhibitors. Biotech France 2017 International Conference and Exhibition, 28 - 30 czerwca 2017, Paris, France.

Posters:

  • Hałdys Katarzyna, Jewgiński Michał, De Los Santos Jesus M., Latajka Rafał: Synthesis and Kinetic Studies of α-Aminophosphonates as Novel Tyrosinase Inhibitors. 24 POLISH PEPTIDE SYMPOSIUM, 3 – 7 September 2017, Jastrzębia Góra, Poland