Katarzyna Macegoniuk

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Born: 13.02.1987, Szczecinek

Hobby: books, good movies, travelling, cooking, sport

Email: katarzyna.macegoniuk@pwr.edu.pl

Education

  • 2011- present - PhD in Biotechnology, Department of Bioorganic Chemistry, Wrocław University of Technology

Supervisor: dr hab. Łukasz Berlicki

  • 2011 – MSc in Biotechnology with Molecular Biotechnology and Biocatalysis, Department of Bioorganic Chemistry, Wrocław University of Technology

Supervisor: dr Krystyna Dąbrowska, Institute of Immunology and Experimental Therapy by the Polish Academy of Science, Wrocław, Poland Master's thesis: " Study of the influence of bacteriophage T4 selected proteins on cytokines and free radicals production by eukaryotic cells."

  • 2009 – BSc in Chemistry, Department of Chemistry, University of Poznan

Supervisor: dr hab. Anna Gąsowska Bachelor's thesis: "Project of chemical workshop for students of middle school "Chemistry in everyday life".

Awards

  • Scholarship from the programme: „Rozwój potencjału dydaktyczno-naukowego Młodej Kadry Akademickiej Politechniki Wrocławskiej” (10th edition 1.04.2014-31.09.2014)
  • Beneficiary of GRANT PLUS programme founded by Human Capital Operational Programme European Union, 2012

Scientific visits

  • Department of Agro-Environmental Science and Technology, University of Bologna, Italy (2013 - 2 weeks, 2014 - 3 weeks)
  • Faculty of Science and Technology, Bioorganic chemistry and Bio-Crystallography laboratory, Free University of Bolzano, Italy (2013 - 1 week)
  • Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań

Patent Applications

  • Agnieszka Grabowiecka, Łukasz Berlicki, Artur Mucha, Anna Dziełak, Katarzyna Macegoniuk, Ewa Grela, Paweł Kafarski; Zastosowanie pochodnych kwasu aminometylofosfinowego;PL 407413, 2014
  • Agnieszka Grabowiecka, Łukasz Berlicki, Artur Mucha, Anna Dziełak, Katarzyna Macegoniuk, Ewa Grela, Paweł Kafarski, Pochodne kwasu aminometylofosfinowego, sposób ich wytwarzania oraz zastosowania; PL 407412, 2014

Conference communications

  • KATARZYNA MACEGONIUK, Anna Dziełak, Artur Mucha, Łukasz Berlicki, Bis(aminomethyl)phosphinic acids as a new inhibitors of bacterial ureases, 22nd Polish Peptide Symposium, 01-05.09.2013, Kudowa Zdrój
  • KATARZYNA MACEGONIUK, Łukasz Berlicki, Studies on purification of bacterial ureases, 22nd Polish Peptide Symposium, 01-05.09.2013, Kudowa Zdrój
  • KATARZYNA MACEGONIUK, Anna Dziełak, Artur Mucha, Łukasz Berlicki, Bis(aminomethyl)phosphinic acids as a new inhibitors of Helicobacter pylori and Proteus mirabilis urease, 10th European Workshop on Phosphorus Chemistry, 18-20.03.2013, Regensburg, Germany
  • KATARZYNA MACEGONIUK, Anna Dziełak, Artur Mucha, Łukasz Berlicki, Pochodne bis(α-aminoalkano)fosfinowe jako inhibitory ureaz bakteryjnych55 Zjazd Towarzystwa Chemicznego i Stowarzyszenia Inżynierów i Techników Przemysłu Chemicznego, 16-20.09.2012, Białystok
  • Miernikiewicz P., Dąbrowska K., Figura G., Piotrowicz A., Owczarek B., Kopciuch A., MACEGONIUK K., Rzewucka K., Górski A., Investigation of T4 phages head proteins effects on cancer-related cytokines. Phages2011 Meeting, 19-21.09.2011, St Hilda’s College, Oxford, UK

Publications

  1. Macegoniuk, K.; Kowalczyk, R.; Rudzińska, A.; Psurski, M.; Wietrzyk, J.; Berlicki, Ł., Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling Bioorg. Med. Chem. Lett. 2017, 27, 1346. View at Publisher
  2. Ntatsopoulos, V.; Vassiliou, S.; Macegoniuk, K.; Berlicki, Ł.; Mucha, A., Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophiles Eur. J. Med. Chem. 2017, 133, 107. View at Publisher
  3. Wavhale, R. D.; Martis, E. A. F.; Ambre, P. K.; Wan, B.; Franzblau, S. G.; Iyer, K. R.; Raikuvar, K.; Macegoniuk, K.; Berlicki, Ł.; Nandan, S. R.; Coutinho, E. C., Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity Bioorg. Med. Chem. 2017, 25, 4835. View at Publisher
  4. Macegoniuk, K.; Grela, E.; Biernat, M.; Psurski, M.; Gościniak, G.; Dziełak, A.; Mucha, A.; Wietrzyk, J.; Berlicki, Ł.; Grabowiecka, A., Aminophosphinates against Helicobacter pylori ureolysis—Biochemical and whole-cell inhibition characteristics PLoS One 2017, 1, 182437. View at Publisher
  5. Kosikowska, P.; Bochno, M.; Macegoniuk, K.; Forlani, G.; Kafarski, P.; Berlicki, Ł., Bisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase J. Enz. Inh. Med. Chem. 2016, 31, 931. View at Publisher
  6. Macegoniuk, K.; Grela, E.; Palus, J.; Rudzińska-Szostak, E.; Grabowiecka, A.; Biernat, M.; Berlicki, Ł., 1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors. J. Med. Chem. 2016, 59, 8125. View at Publisher
  7. Macegoniuk, K.; Dziełak, A.; Mucha, A.; Berlicki, Ł., Bis(aminomethyl)phosphinic acid, a highly promising scaffold for the development of bacterial urease inhibitors. ACS Med. Chem. Lett. 2015, 6, 146. View at Publisher
  8. Miernikiewicz, P.; Dąbrowska, K.; Piotrowicz, A.; Owczarek, B.; Wojas-Turek, J.; Kicielińska, J.; Rossowska, J.; Pajtasz-Piasecka, E.; Hodyra, K.; Macegoniuk, K.; Rzewucka, K.; Kopciuch, A.; Majka, T.; Letarov, A.; Kulikov, E.; Maciejewski, H.; Górski, A., T4 phage and its head surface proteins do not stimulate inflammatory mediator production. PLoS One 2013, 8, 71036. View at Publisher