Katarzyna Ożga

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Born: 24.08.1991, Wrocław

e-mail: katarzyna.ozga@pwr.edu.pl

Hobbies: literature, skiing

ORCID: 0000-0002-2837-283X

Education

Wroclaw University of Science and Technology

2015-2019 PhD in Chemistry, thesis title: Peptide foldamers with aldolase-like activity

2013-2015 MSc in Bioinformatics (in English)

2010-2013 Engineer in Biotechnology


Employment

Wroclaw University of Science and Technology, Department of Bioorganic Chemistry

2020-present full-time Research Assistant hired as a grant contractor in ‘De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhibitors’

2017-2019 grant contractor in ‘Foldameric miniproteins - structure and catalytic function’

2015-2017 grant contractor in ‘Artificial enzymes based on foldamers’


Experience

Design, synthesis and experimental characterization of the peptides with retro-aldolase activity based on mini-proteins such as C-domain of the MvaT protein.

De novo design of novel tertiary α/β structures with the utilization of constrained β-amino acids with the utilization of Rosetta software.

Design, synthesis and experimental characterization of the peptides inhibiting protein-protein interaction, mainly human PD1/PDL1 and human ACE2/RBD of SARS-CoV-2 Spike protein based on mini-proteins, de novo designed peptides or foldameric mimetics of α-helix.


Publications

  1. Stanojlovic, V.; Müller, A.; Moazzam, A.; Hinterholzer, A.; Ożga, K.; Berlicki, Ł.; Schubert, M.; Cabrele, C., A conformationally stable acyclic β-hairpin scaffold tolerating the incorporation of poorly β-sheet-prone amino acids ChemBioChem 2022, 23, e202100604. View at Publisher
  2. Szefczyk, M.; Ożga, K.; Drewniak-Świtalska, M.; Rudzińska-Szostak, E.; Hołubowicz, R.; Ożyhar, A.; Berlicki, Ł., Controlling the conformational stability of coiled-coil peptides with a single stereogenic center of a peripheral β-amino acid residue RSC Adv. 2022, 12, 4640. View at Publisher
  3. Ożga, K.; Berlicki, Ł., Design and Engineering of Miniproteins ACS Bio Med Chem Au 2022, 2, 316. View at Publisher
  4. Ożga, K.; Drewniak-Świtalska, M.; Rudzińska-Szostak, E.; Berlicki, Ł., Towards Foldameric Miniproteins: A Helix‐Turn‐Helix Motif ChemPlusChem 2021, 86, 646. View at Publisher
  5. Grelich-Mucha, M.; Garcia, A. M.; Torbeev, V.; Ożga, K.; Berlicki, Ł.; Olesiak-Bańska, J., Autofluorescence of Amyloids Determined by Enantiomeric Composition of Peptides J. Phys. Chem. B 2021, 125, 5502. View at Publisher
  6. Fortuna, P.; Twarda-Clapa, A.; Skalniak, L.; Ożga, K.; Holak, T. A.; Berlicki, Ł., Systematic ‘foldamerization’ of peptide inhibiting p53-MDM2/X interactions by the incorporation of trans- or cis-2-aminocyclopentanecarboxylic acid residues Eur. J. Med. Chem. 2020, 208, 112814. View at Publisher
  7. Drewniak, M.; Węglarz-Tomczak, E.; Ożga, K.; Rudzińska-Szostak, E.; Macegoniuk, K.; Tomczak, J. M.; Bejger, M.; Rypniewski, W.; Berlicki, Ł., Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics. Bioorg. Chem. 2018, 81, 356. View at Publisher

Publications (submitted/in preparation)

  1. Ożga, K.; Berlicki, Ł. Foldameric mini-protein with aldolase activity. In preparation.
  2. Krzciuk-Gula, J.; Rudzińska-Szostak; E., Świerczek, N.; Ożga, K.; Berlicki, Ł. Exploration of cis-2-aminocyclopentanocarboxylic acid-containing peptide foldamers mimicking 310-helix. In preparation.


Conferences communications (selected)

  1. 25th Polish Peptide Symposium. Wojanów (Poland), September 2019, Ożga, K.; Berlicki, Ł. Artificial aldolase based on mini-protein scaffold. Poster.
  2. 10th International Peptide Symposium. Kyoto (Japan), December 2018, Ożga, K.; Berlicki Ł. Peptidic foldamers as promising scaffolds for incorporation of enzymatic activity. Poster.
  3. Chemistry Beyond Nature, Poznań (Poland), June 2018, Ożga, K.; Ł. Berlicki, Ł. Redesigning of peptidic structures toward enzymatic activity. Poster
  4. Modeling and Design of Molecular Materials, Polanica (Poland), June 2018, Ożga, K.; Berlicki, Ł. Computer-aided design of peptide based aldolase mimetics. Poster
  5. 24th Polish Peptide Symposium, Jastrzębia Góra (Poland), September 2017, Ożga, K.; Berlicki, Ł. α,β-Peptidic foldamers with aldolase-like activity. Poster.
  6. 25th American Peptide Symposium, Whistler (Canada), June 2017, Berlicki, Ł.; Szefczyk, M.; Węglarz-Tomczak, E.; Drewniak, M.; Ożga, K.; Krzysztoń, A.; Rudzińska-Szostak, E.; Krzciuk-Gula, J. Catalytically Active Peptide Foldamers. Poster.
  7. 25th American Peptide Symposium, Whistler (Canada), June 2017, Drewniak, M.; Ożga, K.; Rudzińska-Szostak, E.; Berlicki, Ł. Controlling the Conformational Stability of Helix-loop-helix Peptide Foldamers. Poster.
  8. 34th European Peptide Symposium, Leipzig (Germany), September 2016, Berlicki, Ł.; Wójcik, P.; Szefczyk, M.; Drewniak, M.; Ożga, K.; Węglarz-Tomczak, E.; Krzysztoń, A.; Rudzińska-Szostak, E. Rational design, synthesis and evaluation of catalytically active peptide foldamers. Oral communication.
  9. 10th Copernicus Doctoral Seminar, Toruń (Poland), June 2016, Ożga, K.; Berlicki, Ł . Rational modification of foldameric α,β-peptides with aldolase activity. Oral communication.
  10. 14th National Doctoral Seminar: On the Border of Chemistry and Biology, Karpacz (Poland), May 2016, Ożga, K.; Berlicki, Ł . Peptidic foldamers with enzyme-like activity. Oral communication.