Lauren Eyssen

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Born: 07.03.1989 Somerset west, South Africa

Hobby: reading, music, home DIY projects

e-mail: lauren.eyssen@pwr.wroc.pl

Phone: (+48) 71 320 2455

Google Scholar profile


Education

Ph.D., 2014-2018 (Biochemistry) University of KwaZulu-Natal, Pietermaritzburg, South Africa. “Molecular characterisation of metacaspase 5 and the production of oligopeptidase B-specific single chain variable fragment antibodies for potential animal African trypanosomosis chemotherapies and diagnostics”. Supervisor: Prof. Theresa Coetzer.

M.Sc., 2011-2013 (Biochemistry) University of KwaZulu-Natal, Pietermaritzburg, South Africa. “Studying trypanosomal peptidase antigen targets for the diagnosis of animal African trypanosomiasis”. Supervisor: Prof. Theresa Coetzer

B.Sc., 2010 (Hons) University of KwaZulu-Natal, Pietermaritzburg, South Africa.


Former positions

2018 – 2020 Postdoctoral research fellow in Biochemistry, University of KwaZulu-Natal, Pietermaritzburg, South Africa. Supervisor: Prof. Theresa Coetzer.


Research projects

2019 Foundation for Innovative New Diagnostic (FIND), “Transboundary collaboration to eliminate HAT” Research assistant

2018-2019 Institute of Tropical Medicine (ITM) Antwerp-Bill and Melinda Gates Foundation “Development of a diagnostic inhibition ELISA test for gambiense-human African trypanosomiasis” Research assistant

2012-2014 The Global Alliance for Livestock Veterinary Medicines (GALVMED) “Animal African Trypanosomosis Program” Research assistant


Awards and honours

2019 Awarded a poster prize at the 11th General meeting of the International Proteolysis Society in Mariánské Lázně, Czech Republic.

2019 Travel award to attend the 11th General meeting of the International Proteolysis Society in Mariánské Lázně, Czech Republic.

2019 Travel award to attend the Biophysics & Structural Biology at Synchrotrons workshop in Cape Town, South Africa.

2018 Awarded a 2-year Department of Science and Technology (DST)-National Research Foundation (NRF) South African Research Chair Initiative (SARChI) Chair in Proteolysis in Homeostasis, Health and Disease postdoctoral scholarship.

2014 Awarded a 3-year National Research Foundation (NRF) Scarce Skills Doctoral scholarship.

2014 Travel award to attend the 2nd School on Fundamental Crystallography in Bloemfontein, South Africa.

2011 Awarded a 2-year National Research Foundation (NRF) freestanding Masters scholarship.


Publications (from ISI Master Journal List)

  1. Eyssen, L.E-A.; Coetzer THT, Validation of ligands targeting metacaspase-2 (MCA2) from Trypanosoma brucei brucei and their application to MCA5 from T. congolense as possible trypanocides Journal of Molecular Graphics and Modelling 2020, 97, 107579. View at Publisher
  2. Eyssen, L.E-A.; Coetzer THT, Expression, purification and characterisation of Trypanosoma congolense metacaspase 5 (TcoMCA5) - a potential drug target for animal African trypanosomiasis Protein Expression and Purification 2019, 164, 105465. View at Publisher
  3. Eyssen, L.E-A.; Vather, P.; Jackson, L.; Ximba, P.; Biteau, N.; Balz, T.; Boulange, A.; Buscher, P.; Coetzer THT, Recombinant and native TviCATL from Trypanosoma vivax: Enzymatic characterisation and evaluation as a diagnostic target for animal African trypanosomosis Molecular and Biochemical Parasitology 2018, 223, 50. View at Publisher


Conference communications

1. Eyssen, L.E-A., Coetzer, T.H.T. (2019). Autoprocessing and proteolysis: the catalytic Cys residues of the Trypanosoma congolense metacaspase 5 virulence factor. Poster presentation at the 11th Meeting of the International Proteolysis Society, Mariánské Lázně, Czech Republic.

2. Eyssen, L.E-A., Coetzer, T.H.T. (2019). The trypanosome metacaspases: defining the mode of action of a druggable virulence factor. Poster presentation at the Biophysics & Structural Biology at Synchrotrons workshop, University of Cape Town, Cape Town, South Africa.

3. Eyssen, L.E-A., Coetzer, T.H.T. (2018). Autoprocessing and a second catalytic Cys-residue of metacaspase 5 of Trypanosoma congolense: two arrows in the quiver of a druggable virulence factor. Oral presentation at the 47th Parasitological Society of Southern Africa (PARSA) conference, Tshipise Forever Resort, Limpopo, South Africa.

4. Eyssen, L.E-A., Coetzer, T.H.T. (2018). Oligopeptidase B-specific antibody fragments: possible diagnostic tool for animal infective trypanosomosis. Oral presentation at the South African Society for Biochemistry and Molecular Biology (SASBMB) - Federation of African Societies of Biochemistry and Molecular Biology (FASBMB) conference, North West University, Potchefstroom, South Africa.

5. Eyssen, L.E-A., Coetzer, T.H.T. (2016). The metacaspases of the Trypanosomes. Oral presentation at the 25th South African Society for Biochemistry and Molecular Biology (SASBMB) congress, East London International Convention Centre, South Africa.