Magdalena Klimek-Ochab

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Klimek.jpg

Married: Pawel, son Hubert (2005)

Hobby: mountain hiking

e-mail: magdalena.klimek-ochab@pwr.edu.pl

Education

2014 — Faculty of Chemistry, Gdańsk University of Technology, habilitation in Chemistry (Biotechnology), Habilitation thesis: “Mechanisms of fungal biodegradation of selected phosphonic compounds”.

2003 - Ph.D. in Biology (domain: biochemistry), the University of Wroclaw, Institute of Biochemistry and Molecular Biology (currently Faculty of Biotechnology), doctoral thesis: “Biodegradation of organophosphonic compounds containing the P-C bond by fungi”, supervisor: prof. Barbara Lejczak

1999 - M.Sc. in Biotechnology, the Wroclaw University of Technology (Department of Chemistry), master thesis: “The application of lipolytic microorganisms as biocatalysts in synthesis of optically pure phosphonic acids”, supervisor: prof. Barbara Lejczak

Employment

2005 until now – Assistant Professor, Faculty of Chemistry, Department of Bioorganic Chemistry, Wroclaw University of Technology, Poland

2003 - 2005 – Teaching Assistant, Faculty of Chemistry, Department of Bioorganic Chemistry, Wroclaw University of Technology, Poland

1999-2003 – doctoral studies at Wroclaw University of Technology, Faculty of Chemistry


Fellowships and scientific visits

2003 - University of Ferrara (Italy - 2 months)

1999 - University of Pawia (Italy, 6 months) Socrates/Erasmus;

Research interests

  • characterization of fungal enzymes of oragnophosphonates degradation processes
  • application of fungal cells in biotransformation of wide range of phosphonate derivatives
  • biosynthesis of silica nanoparticles


Publications

  1. Żymańczyk-Duda E, Kozyra K, Brzezińska-Rodak M, Klimek-Ochab M, Baker’s yeasts driven synthesis of enantiomers of ethyl 1-hydroxy-1-(3,4-dimethoxyphenyl)methane(P-phenyl)phosphinate - possible organophosphorus CDA’s Journal of Molecular Catalysis. B, Enzymatic 2017, 1. View at Publisher
  2. Ząbek A, Junka A, Szymczyk P, Wojtowicz W, Klimek-Ochab M, Młynarz P, Metabolomics analysis of fungal biofilm development and of arachidonic acid-based quorum sensing mechanism Journal of Basic Microbiology 2017, 9999, 1. View at Publisher
  3. Ząbek A, Klimek-Ochab M, Jawień E, Młynarz P, Biodiversity in targeted metabolomics analysis of filamentous fungal pathogens by 1H NMR-based studies World J Microbiol Biotechnol 2017, 33, 132. View at Publisher
  4. Majewska P, Serafin M, Klimek-Ochab M, Brzezińska-Rodak M, Żymańczyk-Duda E,, Lipases and whole cell biotransformations of 2-hydroxy-2-(ethoxyphenylphosphinyl)acetic acid and its ester. Bioorganic Chemistry 2016, 66, 21.
  5. Brzezińska-Rodak M, Klimek-Ochab M, Żymańczyk-Duda E, Enzyme-mediated protoplast formation of Cuninghamella echinulata - preliminary studies. BioTechnologia 2016, 97, 27.
  6. Żymańczyk-Duda E, Brzezińska-Rodak M, Klimek-Ochab M, Duda M, Biochemistry - Knowledge to Practical Applications - Examples Basic Biochemistry 2016, 1.
  7. Zymanczyk-Duda, E.; Brzezinska-Rodak, M.; Kozyra, K.; Klimek-Ochab, M., Fungal Platform for Direct Chiral Phosphonic Building Blocks Production. Closer Look on Conversion Pathway Appl. Biochem. Biotechnol. 2015, 175, 1403. View at Publisher
  8. Górak M, Serafin M, Klimek-Ochab M, Żymańczyk-Duda E, Biocatalytic transformation of epoxy- and vinylphosphonates Chemik 2015, 69, 273.
  9. Klimek-Ochab, M.; Mucha, A.; Żymań„czyk-Duda, E, 2-Aminoethylphosphonate Utilization by the Cold-Adapted Geomyces pannorum P11 Strain Curr. Microbiol. 2014, 68, 330. View at Publisher
  10. Klimek-Ochab, M., Phosphate-independent utilization of phosphonoacetic acid as sole phosphorus source by a psychrophilic strain of Geomyces pannorum P15 Folia Microbiologica 2014, 59, 375. View at Publisher
  11. Kmiecik, N.; Klimek-Ochab, M.; Brzezinska-Rodak, M.; Majewska, P.; Zymanczyk-Duda, E., Chiral Phosphinate Degradation by the Fusarium Species: Scope and Limitation of the Process Biotechnology Research International 2013, 2013, 1.
  12. Żymańczyk-Duda, E.; Klimek-Ochab, M., Stereoselective Biotransformations as an Effective Tool for the Synthesis of Chiral Compounds with P-C Bond - Scope and Limitations of the Methods. Curr. Org. Chem. 2012, 16, 1408.
  13. Brzezińska-Rodak, M.; Klimek-Ochab, M.; Żymańczyk-Duda, E., Biocatalyzed synthesis of chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethanephosphonate. Practical methods for biocatalysis and biotransformations 2 2012, 247. View at Publisher
  14. Brzeziń„ska-Rodak, M.; Klimek-Ochab, M.; Żymań„czyk-Duda E.; Kafarski, P., Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid Molecules 2011, 16, 5896. View at Publisher
  15. Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Klimek-Ochab, M.; Lejczak, B., Application of the Beauveria bassiana Strain for the Enantioselective Oxidation of the Diethyl 1-Hydroxy-1-Phenylmethanephosphonate Curr. Microbiol. 2011, 62, 1168. View at Publisher
  16. Klimek-Ochab, M.; Brzeziń„ska-Rodak, M.; Żymań„czyk-Duda, E.; Lejczak, B.; Kafarski, P., Comparative study of fungal cell disruption—scope and limitations of the methods. Folia Microbiol. 2011, 56, 469. View at Publisher
  17. Brzezińska-Rodak, M.; Żymańczyk-Duda, E.; Klimek-Ochab, M.; Lejczak, B., Fungal Cells Permeabilization as a Convenient Tool of Bioreduction Enantioselectivity Control Pol. J. Chem. 2009, 83, 2113.
  18. Żymańczyk-Duda, E.; Brzeziń„ska-Rodak, M.; Klimek-Ochab, M.; Latajka, R.; Kafarski, P.; Lejczak, B., Chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethylphosphonate as a valuable product of microbial biotransformation of diethyl 2-oxo-2-phenylethylphosphonate J. Mol. Cat. B 2008, 52, 74.
  19. Klimek-Ochab, M.; Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Majewska, P.; Lejczak, B., Effective fungal catalyzed synthesis of P-chiral organophosphorus compounds. Tetrahedron: Asymmetry 2008, 19, 450. View at Publisher
  20. Klimek-Ochab M., Degradation of phosphonates by fungi Current Trends in Microbiology 2008, 4, 91.
  21. Szatkowski, P., Klimek-Ochab M., Lejczak, P., Biodegradation of glyphosate B mesophilic fungal strains isolated from the natural environment Modern chemical technology in agriculture and environment protection / ed. by Henryk Górecki [i in.] 2008, 210.
  22. Klimek-Ochab, M.; Obojska, A.; Picco, A.M.; Lejczak, B., Isolation and characterization of two new microbial strains capable of degradation of the naturally occurring organophosphonate - ciliatine. Biodegradation 2007, 18, 223.
  23. Brzezińska-Rodak, M.; Żymańczyk-Duda, E.; Klimek-Ochab, M.; Lejczak, B., Biocatalytical synthesis and further determination of the absolute configuration of diethyl of (R)-2-hydroxybutylphosphonate Pol. J. Chem. 2007, 81, 1911.
  24. Klimek-Ochab, M.; Raucci, G.; Lejczak, B.; Forlani, G., Phosphonoacetate hydrolase from Penicillium oxalicum: Purification and properties, phosphate starvation-independent expression, and partial sequencing. Res. Microbiol. 2006, 157, 125.
  25. Brzezinska-Rodak, M.; Zymanczyk-Duda, E.; Klimek-Ochab, M.; Kafarski, P.; Lejczak, B., A simple and green procedure for the microbial effective synthesis of 1-phenylethyl alcohol in both enantiomeric forms. Biotech. Lett. 2006, 28, 511.
  26. Forlani G., Klimek-Ochab M., Jaworski J., Lejczak B., Picco A. M., Phosphonoacetic acid utilization by fungal isolates: occurrence and properties of a phosphonoacetate hydrolase in some penicillia Mycological Research 2006, 110, 1455.
  27. Grabowiecka, A.; Klimek-Ochab, M.; Lejczak, B., Biodegradation of derivatives of aminomethylene-bisphosphonic acid Chemistry and biochemistry in the agricultural production, environment protection, human and animal health. Ed. by H. Górecki, Z. Dobrzański, P. Kafarski 2006, 224.
  28. Żymańczyk-Duda, E.; Klimek-Ochab, M.; Kafarski, P.; Lejczak, B., Stereochemical control of biocatalytic asymmetric reduction of diethyl 2-oxopropylphosphonate employing yeasts. J. Organomet. Chem. 2005, 690, 2593.
  29. Klimek-Ochab, M.; Lejczak, B.; Forlani, G., A metal-independent hydrolase from a Penicillium oxalicum strain able to use phosphonoacetic acid as the only phosphorus source. FEMS Microbiol. Lett. 2003, 222, 205.
  30. Klimek, M.; Lejczak, B.; Kafarski, P.; Forlani, G., Metabolism of the phosphonate herbicide glyphosate by a non-nitrate-utilizing strain of Penicillium chrysogenum. Pest Menagment Sci. 2001, 57, 815.