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Department of Bioorganic Chemistry is one of 14 departments of Faculty of Chemistry, Wrocław University of Science and Technology. It is headed by Łukasz Berlicki and formed by 5 research groups of: prof. Paweł Kafarski, prof. Artur Mucha, Dr. Łukasz Berlicki, Dr. Rafał Kowalczyk and Dr. Rafał Latajka. The main research areas are on a border of chemistry and biology.


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Research

Publications



Recent papers

Protease-activated prodrugs: strategies, challenges and future directions
Poreba M
FEBS Journal 2020, 1
DOI: 10.1111/febs.15227

Recent papers

Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate dengue from Zika and West Nile viruses
Rut W, Groborz K, Zhang L, Modrzycka S, Poreba M, Hilgenfeld R, Drag M
Antiviral Research 2020, 1
DOI: 10.1016/j.antiviral.2020.104731

Recent papers

Peptide and Pseudopeptide Bond Synthesis in Phosphorus Dipeptide Analogs.
Mucha, A.; Kafarski, P.
Methods Mol. Biol. 2020, 2103, 287
DOI: 10.1007/978-1-0716-0227-0_20
Abstract
Peptide analogs modified with a phosphorus-based moiety (phosphonate, phosphonamidate, or phosphinate)have emerged as invaluable tools in fundamental and medicinal, mechanistic, and inhibitory studies of proteolytic enzymes and other catalytic proteins that process the amino acids and peptides. The first stages of the chemical synthesis of these compounds frequently involve formation of peptide or pseudopeptide bond between a suitably protected α-amino acid and an α-aminoalkyl phosphorus derivative. These preparative protocols are distinct from conventional solution and solid-phase peptide syntheses that have become routine and automatized. In the following chapter, we describe in details the methods and techniques utilized to perform this nonstandard coupling and to obtain P-terminal dipeptidyl phosphonates and pseudodipeptides containing the internal phosphonamidate or phosphinate linkages. Methods of products’ purification, the deprotection conditions, and stability issues are also presented and discussed.

Recent papers

Halogenated aromatic thiosemicarbazones as potent inhibitors of tyrosinase and melanogenesis
Hałdys K., Goldeman W., Jewgiński M., Wolińska E., Anger-Góra N., Rossowska J., Latajka R.
Bioorganic Chemistry 2020, 94, 103419
DOI: 10.1016/j.bioorg.2019.103419

Recent papers

Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Gonçalves I, Nilsson J, Grenegård M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M, Johansen HT, Solberg R, Aukrust P, Björkbacka H, Andersen GØ, Halvorsen B
Atherosclerosis 2019, 1
DOI: 10.1016/j.atherosclerosis.2019.12.008

Recent papers

Applications of Thermal Activation, Ball-milling and Aqueous Medium in Stereoselective Michael Addition of Nitromethane to Enynones Catalyzed by Chiral Squaramides
Ignatiuk, Z. A.; Janicki, M. J.; Gora, R. W.; Konieczny, K.; Kowalczyk, R.
Advanced Synthesis & Catalysis 2019, 361, 1108
DOI: 10.1002/adsc.201801498

Recent papers

Applications of unnatural amino acids in protease probes
Maluch I, Czarna J, Drag M
Chemistry - An Asian Journal 2019, 14, 4103
DOI: 10.1002/asia.201901152

Recent papers

Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections – Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils
Aaltonen N, Singha P, Jakupovic H, Wirth T, Samaranayake H, Pasonen-Seppanen S, Rilla K, Varjosalo M, Edgington-Mitchell L, Kasperkiewicz P, Drag M, Kalvala S, Moisio E, Savinainen JR, Laitinen JT
bioRxiv 2019, 1
DOI: 10.1101/783704

Recent papers

The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes)
Poreba M, Groborz K, Rut W, Pore M, Snipas SJ, Vizovisek M, Turk B, Drag M, Salvesen GS
bioRxiv 2019, 1
DOI: 10.1101/775627

Recent papers

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease
Anderson BM, Poole DP, Aurelio L, Ng GZ, Fleischmann M, Kasperkiewicz P, Morissette C, Drag M, van Driel IR, Schmidt BL, Vanner SJ, Bunnett NW, Edgington-Mitchell LE
Scientific Reports 2019, 9, 13295
DOI: 10.1038/s41598-019-49840-4