Michał Talma

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Talma.jpg

Born: 28.06.1991

hobby: acrobatics, hiking, triathlon, cooking.

email: michal.talma@pwr.edu.pl

phone: +48 71 320 33 54


Education

2015 - present - PhD studies in Chemistry, Department of Bioorganic Chemistry, Wrocław University of Technology Supervisor: Prof. dr hab. inż. Artur Mucha

2015 - 2014 - MSc in Molecular Biotechnology and Biocatalysis, Wrocław University of Technology "Immobilization of drugs in porous structures" Supervisor: Dr inż. Łukasz Radosiński

Publications

  1. Wanat, W.; Talma, M.; Dziuk, B.; Pirat, J.-L.; Kafarski, P., Phosphonic Acid Analogs of Fluorophenylalanines as Inhibitors of Human and Porcine Aminopeptidases N: Validation of the Importance of the Substitution of the Aromatic Ring Biomolecules 2020, 10, 1. View at Publisher
  2. Talma, M.; Mucha, A., P1′ Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases Biomolecules 2020, 10, 659. View at Publisher
  3. Maniak, H.; Talma, M.; Matyja, K.; Trusek, A.; Giurg, M. , Synthesis and structure-activity relationship studies of hydrazide-hydrazones as inhibitors of laccase from trametes versicolor Molecules 2020, 5, 1255. View at Publisher
  4. Talma, M., Phosphinic Dehydrodipeptides: Diversification of the P1′ Residue with the Morita–Baylis–Hillman Acetates and Inhibition of Alanyl Aminopeptidase Int J Pept Res Ther 2020, 1. View at Publisher
  5. Wanat, W. ; Talma, M.; Dziuk, B.; Kafarski, P, Synthesis and Inhibitory Studies of Phosphonic Acid Analogues of Homophenylalanine and Phenylalanine towards Alanyl Aminopeptidases Biomolecules 2020, 10, 1. View at Publisher
  6. Janiszewska, K.; Talma, M.; Oszywa, B.; Pawełczak, M.; Kafarski, P.; Mucha, A.,, N-Benzyl Residues as the P1' Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases Molecules 2020, 25, 4334. View at Publisher
  7. Talma, M.; Maślanka, M.; Mucha, A., Recent developments in the synthesis and applications of phosphinic peptide analogs. Bioorg. Med. Chem. Lett. 2019, 29, 1031. View at Publisher
  8. Wanat, W.; Talma, M.; Pawełczak, M.; Kafarski, P., Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds Pharmaceuticals 2019, 12, 1. View at Publisher
  9. Stosiek, N.; Talma, M.; Klimek-Ochab, M., Carbon-Phosphorus Lyase—the State of the Art Appl. Biochem. Biotechnol. 2019, 1. View at Publisher
  10. Ewelina Węglarz-Tomczak, Michał Talma, Mirosław Giurg, Hans V. Westerhoff, Robert Janowski and Artur Mucha, Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs Oncotarget 2018, 9, 29365. View at Publisher
  11. P. Kafarski, M. Talma, Recent advances in design of new urease inhibitors: A review J. Adv. Res. 2018, 13, 101. View at Publisher
  12. Wanat, W.; Talma, M.; Hurek, J.; Pawełczak, M.; Kafarski, P., Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes Biochimie 2018, 151, 119. View at Publisher
  13. Talma, M.; Mucha, A., P-C bond formation in reactions of Morita-Baylis-Hillman adducts with phosphorus nucleophiles. Arkivoc 2017, 2017, 324. View at Publisher
  14. Węglarz-Tomczak, E.; Staszewska, K.; Talma, M.; Mucha, A., Enantiomeric a,ß-diaminoethylphosphonic acids as potent inhibitors of aminopeptidases — stereoselective synthesis and biological activity. Tetrahedron Lett. 2016, 57, 4812. View at Publisher

Conference communications

  1. Michał Talma, Artur Mucha, oral presentation: "Synthesis of phosphinodehydropeptides and molecular modeling of interactions in the active sites of metalloaminopeptidases", European Workshop on Phosphorus Chemistry - EWPC 14/2017, Cluj-Napoca, Romania, 20-22.03.2017 r.
  2. Michał Talma, Artur Mucha, oral presentation: "Modelowanie oddziaływań fosfinodehydrodipeptydów i fosfinodipeptydów w centrum aktywnym ludzkiej aminopeptydazy N", COMBINAT - Conference of Modeling in BIo and NAno Technology, Wrocław, 04-05.03.2017 r.
  3. Michał Talma, Ewelina Węglarz-Tomczak, Katarzyna Staszewska, Artur Mucha, poster presentation: "P1 and P1’ Modified Phosphinic Dipeptide Analogue Inhibitors of Metalloaminopeptidases", 34th European Peptide Symposium and the 8th International Peptide Symposium, Lipsk, 04-09.09.2016 r.
  4. Michał Talma, Artur Mucha, poster presentation: "Modelowanie oddziaływań fosfinodipeptydów i dehydrodipeptydów w centrach aktywnych wybranych metaloaminopeptydaz", X Kopernikańskie Seminarium Doktoranckie, Brodnica, 21-24.06.2016 r.
  5. Michał Talma, Artur Mucha, oral presentation: "Fosfinopeptydy i fosfinodehydropeptydy jako inhibitory metaloaminopeptydaz", X Kopernikańskie Seminarium Doktoranckie, Brodnica, 21-24.06.2016 r.
  6. Michał Talma, Artur Mucha, oral presentation: "Zastosowanie adduktów Mority-Baylisa-Hillmana w syntezie bioaktywnych związków fosforoorganicznych", XIV Seminarium Doktorantów "Na pograniczu chemii i biologii", Karpacz, 22-25.05.2016 r.
  7. Michał Talma, oral presentation: "Immobilizacja leków na strukturach porowatych". Ogólnopolska konferencja "Procesy jednostkowe i modelowanie komputerowe w biotechnologii", Wrocław, 29.05.2015 r.
  8. Michał Talma, poster presentation: "Immobilization of drugs in porous structures". 3rd International Workshop of Molecular Modelling WAMMBAT, Wrocław, 02.2015 r.

Organizer

  1. 3rd International Workshop of Molecular Modelling WAMMBAT.