Michał Talma

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Talma.jpg

Born: 28.06.1991

hobby: acrobatics, hiking, triathlon, cooking.

email: michal.talma@pwr.edu.pl

phone: +48 71 320 33 54


Education

2015 - present - PhD studies in Chemistry, Department of Bioorganic Chemistry, Wrocław University of Technology Supervisor: Prof. dr hab. inż. Artur Mucha

2015 - 2014 - MSc in Molecular Biotechnology and Biocatalysis, Wrocław University of Technology "Immobilization of drugs in porous structures" Supervisor: Dr inż. Łukasz Radosiński

Publications

  1. Wanat, W.; Talma, M.; Dziuk, B.; Pirat, J.-L.; Kafarski, P., Phosphonic Acid Analogs of Fluorophenylalanines as Inhibitors of Human and Porcine Aminopeptidases N: Validation of the Importance of the Substitution of the Aromatic Ring Biomolecules 2020, 10, 1. View at Publisher
  2. Talma, M.; Mucha, A., P1′ Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases Biomolecules 2020, 10, 659. View at Publisher
  3. Maniak, H.; Talma, M.; Matyja, K.; Trusek, A.; Giurg, M. , Synthesis and structure-activity relationship studies of hydrazide-hydrazones as inhibitors of laccase from trametes versicolor Molecules 2020, 5, 1255. View at Publisher
  4. Talma, M., Phosphinic Dehydrodipeptides: Diversification of the P1′ Residue with the Morita–Baylis–Hillman Acetates and Inhibition of Alanyl Aminopeptidase Int J Pept Res Ther 2020, 1. View at Publisher
  5. Talma, M.; Maślanka, M.; Mucha, A., Recent developments in the synthesis and applications of phosphinic peptide analogs. Bioorg. Med. Chem. Lett. 2019, 29, 1031. View at Publisher
  6. Wanat, W.; Talma, M.; Pawełczak, M.; Kafarski, P., Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds Pharmaceuticals 2019, 12, 1. View at Publisher
  7. Stosiek, N.; Talma, M.; Klimek-Ochab, M., Carbon-Phosphorus Lyase—the State of the Art Appl. Biochem. Biotechnol. 2019, 1. View at Publisher
  8. Ewelina Węglarz-Tomczak, Michał Talma, Mirosław Giurg, Hans V. Westerhoff, Robert Janowski and Artur Mucha, Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs Oncotarget 2018, 9, 29365. View at Publisher
  9. P. Kafarski, M. Talma, Recent advances in design of new urease inhibitors: A review J. Adv. Res. 2018, 13, 101. View at Publisher
  10. Weronika Wanat, Michał Talma, Józef Hurek, Małgorzata Pawełczak, Paweł Kafarski, Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes Biochimie 2018, 151, 119. View at Publisher
  11. Talma, M.; Mucha, A., P-C bond formation in reactions of Morita-Baylis-Hillman adducts with phosphorus nucleophiles. Arkivoc 2017, 2017, 324. View at Publisher
  12. Węglarz-Tomczak, E.; Staszewska, K.; Talma, M.; Mucha, A., Enantiomeric a,ß-diaminoethylphosphonic acids as potent inhibitors of aminopeptidases — stereoselective synthesis and biological activity. Tetrahedron Lett. 2016, 57, 4812. View at Publisher

Conference communications

  1. Michał Talma, Artur Mucha, oral presentation: "Synthesis of phosphinodehydropeptides and molecular modeling of interactions in the active sites of metalloaminopeptidases", European Workshop on Phosphorus Chemistry - EWPC 14/2017, Cluj-Napoca, Romania, 20-22.03.2017 r.
  2. Michał Talma, Artur Mucha, oral presentation: "Modelowanie oddziaływań fosfinodehydrodipeptydów i fosfinodipeptydów w centrum aktywnym ludzkiej aminopeptydazy N", COMBINAT - Conference of Modeling in BIo and NAno Technology, Wrocław, 04-05.03.2017 r.
  3. Michał Talma, Ewelina Węglarz-Tomczak, Katarzyna Staszewska, Artur Mucha, poster presentation: "P1 and P1’ Modified Phosphinic Dipeptide Analogue Inhibitors of Metalloaminopeptidases", 34th European Peptide Symposium and the 8th International Peptide Symposium, Lipsk, 04-09.09.2016 r.
  4. Michał Talma, Artur Mucha, poster presentation: "Modelowanie oddziaływań fosfinodipeptydów i dehydrodipeptydów w centrach aktywnych wybranych metaloaminopeptydaz", X Kopernikańskie Seminarium Doktoranckie, Brodnica, 21-24.06.2016 r.
  5. Michał Talma, Artur Mucha, oral presentation: "Fosfinopeptydy i fosfinodehydropeptydy jako inhibitory metaloaminopeptydaz", X Kopernikańskie Seminarium Doktoranckie, Brodnica, 21-24.06.2016 r.
  6. Michał Talma, Artur Mucha, oral presentation: "Zastosowanie adduktów Mority-Baylisa-Hillmana w syntezie bioaktywnych związków fosforoorganicznych", XIV Seminarium Doktorantów "Na pograniczu chemii i biologii", Karpacz, 22-25.05.2016 r.
  7. Michał Talma, oral presentation: "Immobilizacja leków na strukturach porowatych". Ogólnopolska konferencja "Procesy jednostkowe i modelowanie komputerowe w biotechnologii", Wrocław, 29.05.2015 r.
  8. Michał Talma, poster presentation: "Immobilization of drugs in porous structures". 3rd International Workshop of Molecular Modelling WAMMBAT, Wrocław, 02.2015 r.

Organizer

  1. 3rd International Workshop of Molecular Modelling WAMMBAT.