Patrycja Ledwoń

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Born: May 23, 1994, Lubliniec, Poland

Hobby: cooking, mountaineering, traveling, language learning

Address:

Department of Bioorganic Chemistry,

Faculty of Chemistry,

Wroclaw University of Science and Technology,

Wybrzeże Wyspianskiego 27,

50-370 Wroclaw, Poland

Tel: 0048 71 320 2461, Fax: 0048 71 320 2427

e-mail: patrycja.ledwon@pwr.edu.pl


Education

  • 2018-present: Participant of BioTechNan – interdisciplinary doctoral studies and internship programme. PhD studies in Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology. Current research: Design, synthesis and biological investigation of new peptides and peptidomimetics preventing skin damage. Supervisors: prof. Rafał Latajka and prof. Paolo Rovero (University of Florence, Italy).
  • Feb-June 2018: Erasmus+ exchange programme, Faculty of Chemistry, University of Florence. Project title: Development of a diagnostic technology based on mass spectrometry to fish out biologically relevant glycopeptides by phenylboronic-modified resin. Supervisors: prof. Anna Maria Papini, prof. Paolo Rovero.
  • 2016-2018: MSc in Medical Chemistry, Chemistry and Stereochemistry of Peptides and Proteins Research Group (prof. Zbigniew Szewczuk), Faculty of Chemistry, University of Wroclaw. Thesis title: Synthesis of new Safirinium compounds and their application as ionization tags (funded by KNOW grant). Supervisor: dr. Marek Cebrat.
  • 2013-2016: BSc in Medical Chemistry, Crystallography Research Group (prof. Tadeusz Lis), Faculty of Chemistry, University of Wroclaw. Thesis title: Calcium and iron(II) ascorbates. Supervisor: prof. Tadeusz Lis.


Interships

  • April-August 2021: Laboratory of Peptide and Protein Chemistry and Biology, Interdepartmental Research Unit "PeptLab", University of Florence. Supervisor: prof. Paolo Rovero (funded by European Peptide Society Mobility Fellowship).
  • August-September 2020: Faculty of Chemistry, University of Florence. PhD thesis development. Supervisors: prof. Anna Maria Papini, prof. Paolo Rovero (funded by BioTechNan scholarship).
  • March-June 2020: Erasmus+ internship programme, Faculty of Chemistry, University of Florence. Project title: Professional development in the field of bioorganic chemistry. Supervisor: prof. Anna Maria Papini.
  • June-Sept. 2019: BioTechNan internship programme, Faculty of Chemistry, University of Florence. PhD thesis development. Supervisors: prof. Anna Maria Papini, prof. Paolo Rovero.
  • July-Sept. 2018: Erasmus+ internship programme, Faculty of Chemistry, University of Florence. Project title: Development of a diagnostic technology based on mass spectrometry to fish out biologically relevant glycopeptides by phenylboronic-modified resin. Supervisors: prof. Anna Maria Papini, prof. Paolo Rovero.


Awards

November 2021: The Rector’s Award for scientific activity in 2020/21

April 2021: The Wroclaw University of Science and Technology Own Fund Scholarship (Własny Fundusz PWr)

May 2019: XVII Polish Seminary for Students “Na Pograniczu Chemii i Biologii”, Jastrzębia Góra. The Award for one of the best conference oral presentations for Serpins’ role in skin treatment: structure, active fragments and mechanism of inhibition


Publications

  1. M. Kijewska, F. Nuti, M. Wierzbicka, M. Waliczek, P. Ledwoń, A. Staśkiewicz, F. Real-Fernandez, G. Sabatino, P. Rovero, P. Stefanowicz, Z. Szewczuk, A.M. Papini An Optimised Di Boronate ChemMatrix Affinity Chromatography to Trap Deoxyfructosylated Peptides as Biomarkers of Glycation, Molecules 2020, 25(3), 755; DOI: 10.3390/molecules25030755. IF: 3,267. Punkty MNiSzW: 100.
  2. P. Ledwoń, A. Staśkiewicz, M. Jewgiński, R. Latajka Wpływ reszt ΔPhe na konformację łańcucha peptydowego, Wiadomości Chemiczne 2020, 74(1-2), 9-32. Punkty MNiSzW: 5.
  3. J. Krzciuk-Gula, P. Ledwoń, A. Staśkiewicz, R. Latajka Wpływ różnych reszt β-aminokwasowych na zdolności koordynacyjne peptydów wobec jonów metali przejściowych, Wiadomości Chemiczne 2020, 74(3-4), 285-310. Punkty MNiSzW: 5.
  4. F. Errante, P. Ledwoń, R. Latajka, P. Rovero, A.M. Papini Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy, Frontiers in Chemistry 2020, 8(572923); DOI: 10.3389/fchem.2020.572923. IF: 3,693. Punkty MNiSzW: 100.
  5. P. Ledwoń, F. Errante, A.M. Papini, P. Rovero, R. Latajka Peptides as Active Ingredients: a Challenge for Cosmeceutical Industry, Chemistry & Biodiversity 2021, 18(e2000833); DOI: 10.1002/cbdv.202000833. IF: 2,039. Punkty MNiSzW: 70.
  6. A. Staśkiewicz, P. Ledwoń, P. Rovero, A.M. Papini, R. Latajka Triazole-Modified Peptidomimetics: An Opportunity for Drug Discovery and Development, Frontiers in Chemistry 2021, 9(674705); DOI: 10.3389/fchem.2021.674705. IF: 3,693. Punkty MNiSzW: 100.
  7. P. Ledwoń, A.M. Papini, P. Rovero, R. Latajka Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation, Materials 2021, 14(12), 3217-46. DOI: 10.3390/ma14123217. IF: 3,057. Punkty MNiSzw: 140.


Conference communications

Oral presentations:

  1. 17-19.11.2020: IV Doctoral Forum, Jan Kochanowski University, Kielce (Poland). P. Ledwoń, C. Bello, A.M. Papini, P. Rovero, R. Latajka Design, synthesis and biological investigation of new peptides and peptidomimetics preventing skin damage (presenting author, EN)
  2. 8-12.09.2019: 25th Polish Peptide Symposium, Wojanów. M. Kijewska, F. Nuti, M. Wierzbicka, M. Waliczek, P. Ledwoń, A. Staśkiewicz, T. Koch, F. Real-Fernandez, G. Sabatino, P. Rovero, P. Stefanowicz, Z. Szewczuk, A.M. Papini The novel Boronic-ChemMatrix Resin to selectively fish out deoxyfructosylated peptides (co-author, EN)
  3. 12-15.05.2019: XVII Polish Seminary for Students “Na Pograniczu Chemii i Biologii”, Jastrzębia Góra. P. Ledwoń, F. Errante, M. Jewgiński, P. Rovero, R. Latajka Serpins’ role in skin treatment: structure, active fragments and mechanism of inhibition (presenting author, EN)
  4. 23-17.09.2021: 63. Zjazd Naukowy Polskiego Towarzystwa Chemicznego, Łódź (Poland). P. Ledwoń, C. Bello, A.M. Papini, P. Rovero, R. Latajka Synthesis and Structural Investigations of Novel Peptidomimetics with Elastase Inhibitory Properties (presenting author, EN)
  5. 24-25.06.2021: ChemBiotIC (Chemistry & Biotechnology International Conference), Wrocław (Poland). P. Ledwoń, C. Bello, A.M. Papini, P. Rovero, R. Latajka Design, Synthesis and Structural Investigations of Novel Peptide‑Based Elastase Inhibitors with Fluorescent Properties (presenting author, EN)


Posters:

  1. 8-12.09.2019: 25th Polish Peptide Symposium, Wojanów. P. Ledwoń, F. Errante, M. Jewgiński, P. Rovero, R. Latajka Serpins’ role in skin treatment: structure, active fragments and mechanism of inhibition (presenting author, EN)
  2. 21-26.04.2018: 6th Conference of the Polish Mass Spectrometry Society, Miedzeszyn. M. Cebrat, P. Ledwoń, M. Bochynek, J. Fedorowicz, J. Sączewski, Z. Szewczuk Application of Safirinium ionisation tags to the analysis of peptides and proteins (co-author, EN)
  3. 3-7.09.2017: 24th Polish Peptide Symposium, Jastrzębia Góra. P. Ledwoń, M. Cebrat, Z. Szewczuk Synthesis of fluorescent dyes Safirinium and their role in Mass Spectrometry as a peptide markers (presenting author, EN)
  4. 3-7.09.2017: 24th Polish Peptide Symposium, Jastrzębia Góra. M. Cebrat, P. Ledwoń, M. Wierzbicka, J. Fedorowicz, J. Sączewski, Z. Szewczuk Ultrasensitive method of protein detection using mass spectrometry and oligocyclic ionization tags (co-author, EN)