Paulina Majewska

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Hobby: swimming.

E-mail: paulina.majewska@pwr.wroc.pl

Phone: +48 71 320 46 14, Fax: +48 71 328 24 27

Address: Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland


Education

2012 - Postgraduate Diploma - Manager of Research Projects - University of Economics and Innovation in Lublin

2007 - Ph.D. Chemistry - Wrocław University of Technology, Faculty of Chemistry

2001 - M.Sc. Chemistry - University of Wrocław, Faculty of Chemistry

Foreign training periods

2007 University of Louis Pasteure, Faculty of Pharmacy (post-doctoral stay 12 months)


Research interests

  • Biological chemistry of phosphorus, especially biologically active hydroxyphosphonates.
  • Biotransformations of phosphonates by enzymes or whole bacterial cells.
  • Using NMR methods for determination of absolute configuration.


Professional memberships

Polish Chemical Society (since 2008)


Awards

2008 - Award of Polish Chemical Society


Patents

2014 - PL 217068 B1 - Domestic patent: "Kwas (2RR,S)-2-butyryloksy-2-[((P)R,S)-izobutoksyetoksyfosfinylo]octowy oraz sposób jego wytwarzania"

2009 - WO 2009/153447 A1 (23.12.2009) - International patent: "Oral galenic form, poymer production metod and use of same"


Publications


2015

Majewska P., Biotransformations of 2-hydroxy-2-(ethoxyphenylphosphinyl)acetic acid and the determination of the absolute configuration of all isomers. Bioorg. Chem. 2015, 61, 28.


2014

Hrydziuszko A., Dmytryk A., Majewska P., Szymańska K., Liesiene J., Jarzębski A., Bryjak J., Screening of lipase carriers for reactions in water, biphasic and pure organic solvent systems Acta Biochimica Polonica 2014, 61, 1.

Szyszkowiak J., Majewska P., Determination of absolute configuration by 31P NMR. Tetrahedron: Asymmetry 2014, 25, 103.


2013

Kmiecik N., Klimek-Ochab M., Brzezińska-Rodak M., Majewska P., Zymańczyk-Duda E., Chiral phosphinate degradation by the Fusarium species: scope and limitation of the process. Biotechnology Research International 2013, 2013, 1.

Szyszkowiak J., Majewska P., Microbial biotransformation of two phosphonoacetic acid derivatives bearing two stereomeric centres BioTechnologia 2013, 94, 425.


2011

Malinowska, B.; Majewska, P.; Szatkowski, P.; Kafarski, P.; Lejczak, B., Kinetic resolution of (±)-diethyl- and dibenzyl hydroxy(phenyl)methanephosphonates and their acyl derivatives with lipases Biocatalysis and Biotransformation, 2011, 29, 271.


2010

Majewska, P.; Kafarski, P.; Lejczak.B., Enzymatic resolution of ethyl α-hydroxyphosphinates in a modified reaction environment Phosphorus, Sulfur andSilicon 2010, 185, 1915.

Beesh, M.; Majewska, P.; Vandamme, Th. F., Synthesis and characterization of dextran esters as coating or matrix systems for oral delivery of drugs targeted to the colon International Journal of Drug Delivery 2010, 2, 22.


2009

Majewska, P.; Doskocz, M.; Lejczak, B.; Kafarski, P., Enzymatic resolution of α-hydroxyphosphinates with two stereogenic centres and determination of absolute configuration of stereoisomers obtained. Tetrahedron Asymm. 2009, 20, 1568.


2008

Klimek-Ochab, M.; Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Majewska, P.; Lejczak, B., Effective fungal catalyzed synthesis of P-chiral organophosphorus compounds. Tetrahedron: Asymmetry 2008, 19, 450.


2006

Majewska, P.; Kafarski, P.; Lejczak, B.; Bryndal, I.; LIs, T., An approach to the synthesis and assignment of the absolute configuration of all enantiomers of ethyl hydroxy(phenyl)methane(P-phenyl)phosphinate Tetrahedron: Asymm. 2006, 17, 2697.

Majewska, P.; Kafarski, P.; Lejczak, B., Simple and effective method for the deracemization of ethyl 1-hydroxyphosphinate using biocatalysts with lipolytic activity Tetrahedron: Asymmetry 2006, 17, 2870.


2005

Majewska, P.; Kafarski, P.; Lejczak, B., Lipase-catalysed resolution of 1-hydroxyethane-P-phenylphosphinates. Pol. J. Chem. 2005, 79, 561.