Paweł Kafarski

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Education:

Dembowski High School # 13 in Zielona Góra;

M.S. 1971 , Wrocław University of Technology;

Ph.D. 1977, Wrocław University of Techhnology

Married (Dorota) and have two children (Błażej and Krzysztof).

Major teachers: Dr Zbigniew Czarnuch (high school) and Prof. Przemysław Mastalerz (university).

Hobby: hiking in Tatra Mountains; collecting post-stamps; collecting mushrooms.

e-mail: pawel.kafarski@pwr.wroc.pl

phone : +48 71 320 36 82

Research interests

The main stream of research considers design and synthesis of biologically active compounds within the group of compounds belonging to aminophosphonates 1 and phosphono peptides 2 and 3.

Kafarski compounds.gif

The studies are focused on inhibitors of specific enzymes in order to find out potential; magents against civilization diseses such as: cancer (aminopeptidases and cathepsins), tuberculosis (glutamine synthetase), malaria (aminopeptidases) or osteoporosis. Also search for new plant growth regulators and herbicides is carried out, which starts from screening of physiological activity of aminophosphopnates followed by determination of their molecular mechanisms of action or by design of specific plant enzyme inhibitors. In order to discover such compounds numerous efforts for their synthesis have been undertaken. They include elaboration of new synthetic schemes leading to aminophosphonates and phosphono peptides including stereospecific synthesis by means of conventional methods and biocatalysis. Also chemical properties of aminophosphonic acids and their derivatives have been studies, which include their configuration in solutions, formation of complexes with metal ions, spectroscopic studies, self-organization in solid phase and supramolecular properties. Also biodegradation of aminophosphonates, especially herbicide glyphosate, is studied in some details by NMR technique.

Professional memberships

Polish Chemical Society (President), American Chemical Society, European Peptide Society

Awards

Honorary Member of Slovak Chemical Society, Jan Hanus Medal (Czech Cemical Society), Włodzimierz Trzebiatowski Medal (Technological University of Wroclaw), numerous awards of Polish Minister of Science and Higher Education

Recent Publications

  1. Giberti, S.; Bertazzini, M.; Liboni, M.; Berlicki, Ł.; Kafarski, P.; Forlani, G., Phytotoxicity of aminobisphosphonates targeting both δ1-pyrroline-5-carboxylate reductase and glutamine synthetase Pest Manag. Sci. 2017, 72, 435. View at Publisher
  2. Rydzewska, A.; Olender, A.; Mucha, A.; Kafarski, P., Diethyl boronobenzylphosphonates as substrates in Petasis reactions ARKIVOC 2017, 2017, 107. View at Publisher
  3. Miszczyk, P.; Turowska-Tyrk, I.; Kafarski, P.; Chmielewska, E., Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions Molecules 2017, 22, 1. View at Publisher
  4. Drzyzga, D.; Forlani, G.; Vermander, J.; Kafarski, P.; Lipok, J., Biodegradation of the aminopolyphosphonate DTPMP by the cyanobacterium Anabaena variabilis proceeds via a C–P lyase-independent pathway Environm. Microbiol. 2017, 19, 1065. View at Publisher
  5. M. Makowski, M. Jewgiński, J. Hurek, A. Poliwoda, P. Kafarski, Kinetics of photochemical isomerization of TFA-Gly-ZΔPhe into TFA-Gly-EΔPhe ARKIVOC 2017, 4, 88. View at Publisher
  6. A. Bereska, P. Kafarski, B, Bereska, B. Tkacz, J. Iłowska, J. Lenza, The application of organophosphorus flame-retardants in epoxy resin J. Vinyl. Addit. Technol. 2017, 21, 142. View at Publisher
  7. Lenartowicz, P., Dziuk, B.; Zarychta, B.; Makowski, M.; Kafarski P., Michael additions to double bonds of esters of N-protected (s)-phenylalanyldehydroalanine (X-(s)-Phe-ΔAla-OMe) and its phosphonic acid counterpart (X-(s)-Phe-ΔAla-PO(OEt)2) Phosphorus, Sulfur, Silicon Relat. Elements 2017, 192, 706. View at Publisher
  8. Rydzewska, A.; Mangold, A,; Wanat, W.; Kafarski, P., Diethyl boronobenzylphosphonates as substrates in Suzuki–Miyaura reaction Phosphorus, Sulfur, Silicon Relat. Elements 2017, 192, 758. View at Publisher
  9. Lenartowicz, P.; Makowski, M.; Oszywa, B.; Haremza, K.; Latajka, R.; Pawełczak, M.; Kafarski, P., Addition of thiols to the double bond of dipeptide C -terminal dehydroalanine as a source of new inhibitors of cathepsin C Biochimie 2017, 139, 46. View at Publisher
  10. Kosikowska, P.; Bochno, M.; Macegoniuk, K.; Forlani, G.; Kafarski, P.; Berlicki, Ł., Bisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase J. Enz. Inh. Med. Chem. 2016, 31, 931. View at Publisher
  11. Górny vel Górniak, M.; Kafarski, P., Preparation of the library of fluorescent aromatic aminophosphonate phenyl and benzyl esters Phosphorus, Sulfur, Silicon Relat. Elem. 2016, 191, 511. View at Publisher
  12. Chmielewska, E.; Kafarski, P., Physiologic Activity of Bisphosphonates – Recent Advances Open Pharm. Sci. J. 2016, 3, 56. View at Publisher
  13. Dziuganowska, Z. A.; Ślepokura, A.; Volle, J.-N.; Virieux, D.; Pirat, J.-L.; Kafarski, P., Structural Analogues of Selfotel J. Org. Chem. 2016, 81, 4947. View at Publisher
  14. Grela, E.; Dziełak, A.; Szydowska, K.; Mucha, A.; Kafarski, P.; Grabowiecka, A.M., Whole-cell Proteus mirabilis urease inhibition by aminophosphinates for the control of struvite formation. J. Med. Microbiol. 2016, 65, 1123. View at Publisher
  15. Chmielewska, E.; Kafarski, P., Synthetic procedures leading towards aminobisphosphonates Molecules 2016, 21, 1. View at Publisher
  16. Dobosz, A.; Spychała, J.; Ptak, T.; Chmielewska, E.; Maciejewska, G.; Kafarski, P.; Młynarz, P. , Electrochemical and spectroscopic investigations of selected N-heteroalkylaminomethylenebisphosphonic acids with Pb(II) ions Coord. Chem. Rev. 2016, 327-328, 271. View at Publisher
  17. Studnik, H.; Liebsch, S.; Forlani, G.; Wieczorek, D.; Kafarski, P.; Lipok, J., Amino polyphosphonates – chemical features and practical uses, environmental durability and biodegradation New Biotechnol. 2015, 32, 1. View at Publisher
  18. Lenartowicz, P.; Kafarski, P.; Lipok, J., The overproduction of 2,4-DTBP accompanying to the lack of available form of phosphorus during the biodegradative utilization of aminophosphonates by Aspergillus terreus Biodegradation 2015, 26, 65. View at Publisher
  19. Oszywa, B.; Pawełczak, M.; Kafarski, P, The influence of alpha-aminophosphonic acids on the activity of aminopeptidase from barley seeds—an approach to determine the enzyme specificity Acta Physiol. Plant. 2015, 37, 1. View at Publisher
  20. Chmielewska, E.; Miszczyk, P.; Kozłowska, J.; Prokopowicz, M.; Młynarz, P.; Kafarski. P., Reaction of benzolactams with triethyl phosphite prompted by phosphoryl chloride affords benzoannulated monophosphonates instead of expected bisphoshonates J. Organomet. Chem. 2015, 785, 84. View at Publisher
  21. Kiełbowicz, Z.; Piątek, A.; Bieżyński, J.; Skrzypczak, P.; Chmielewska, E. Kafarski, P.; Kuryszko, J., Improvement of large animal model for studying osteoporosis Bull. Vet. Inst. Pulawy 2015, 59, 123. View at Publisher
  22. Kafarski, P.; Lipok, M., Chapter 11. Structural analogy - direct similarity versus topographical complementarity book: Drug Discovery and Development - From Molecules to Medicine 2015, 2015, 241. View at Publisher
  23. Dobosz, A.; Spychała, J.; Ptak, T.; Maciejewska, G.; Chmielewska, E.; Kafarski, P.; Młynarz, P., Interactions of N-heteroalkylaminomethylenebisphosphonic acids with Cd(II) ions: Electrochemical and spectroscopic investigations Inorg. Chim. Acta 2015, 435, 82. View at Publisher
  24. Kafarski, P.; Górny vel Górniak, M.; Andrasiak, I., Kabachnik-Fields Reaction Under Green Conditions – A Critical Overview Curr. Green Chem. 2015, 2, 218. View at Publisher
  25. Maciejczyk, E.; Wieczorek, D.; Zwyrzykowska, A.; Halama, M.; Jasicka-Misiak, I., Kafarski, P., Phosphorus profile of Basidomycetes Phosphorus, Sulfur, Silicon Relat. Elem. 2015, 190, 763. View at Publisher
  26. Makowski, M.; Lenartowicz, :P.; Oszywa, B.; Jewgiński, M.; Pawełczak, M.; Kafarski, P., Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C Med. Chem. Res. 2015, 24, 3157. View at Publisher
  27. Kiełbowicz, Z.; Piątek, A.; Bieżyński, J.; Skrzypczak, P.; Kuropka, P.; Kuryszko, J.; Nikodem, A.; Kafarski, P.; Cezowicz, P., The Experimental Osteoporosis in Sheep – Clinical Approach Pol. J. Veterinary Sci. 2015, 18, 645. View at Publisher
  28. Kiełbowicz, Z.; Piątek, A.; Bieżyński, J.; Skrzypczak, P.; Kuropka, P.; Kuryszko, J.; Nikodem, A.; Kafarski, P.; Cezowicz, P., The Experimental Osteoporosis in Sheep – Clinical Approach Pol. J. Veterinary Sci. 2015, 18, 645. View at Publisher
  29. Chmielewska, E.; Mazur, Z.; Kempińska, K.; Wietrzyk, J.; Piątek, A.; Kuryszko, J. J.; Kiełbowicz, Z; Kafarski P., N-Arylaminomethylenebisphosphonates Bearing Fluorine Atoms: synthesis and Antiosteoporotic Activity Phosphorus, Sulfur, Silicon Relat. Elem 2015, 190, 2164. View at Publisher
  30. Jewgiński, M; Krzciuk-Gula, J.; Makowski, M.; Latajka, R. Kafarski P., Conformation of dehydropentapeptides containing four achiral amino acid residues – controlling the role of L-valine Beilstein J. Org. Chem. 2014, 10, 660. View at Publisher
  31. Górny vel Górniak, M.; Czernicka, A.; Mł‚ynarz, P., Balcerzak, W.; Kafarski, P., Synthesis of fluorescent (benzyloxycarbonylamino)(aryl)methylphosphonates Beilstein J. Org. Chem. 2014, 10, 741. View at Publisher
  32. Wilk, A.; Kafarski, P., Kultowe bestie - literatura a nauka Wiad. Chem. 2014, 68, 1.
  33. Zieliński, Ł.; Deja, S.; Jasicka-Misiak, I.; Kafarski, P., Chemometrics as a Tool of Origin Determination of Polish Monofloral and Multifloral Honeys J. Agric. Food. Chem. 2014, 62, 2973. View at Publisher
  34. Górecki, Ł.; Mucha, A.; Kafarski, P., Addition of H-phosphonates to quinine-derived carbonyl compounds. An unexpected C9 phosphonate–phosphate rearrangement and tandem intramolecular piperidine elimination. Beilstein J. Org. Chem. 2014, 10, 883. View at Publisher
  35. Dziuganowska, Z. A; Andrasiak, I.; Ślepokura K.; Kafarski, P., Amidoalkylation of Phosphorus Trichloride with Acetamide and Fuctionalized Cyclic Ketones - Evidence of dominating Role of Side-Reactions Phosphorus, Sulfur, Silicon Relat. Elem. 2014, 189, 1. View at Publisher
  36. Candy, M.; Rosseaux S. A. L.; Cirugeda San Roman, A.; Szymczyk, M.; Kafarski, P.; Leclerc, E.; Vrancken, E.; Campagne, J.-M., Palladium-Catalyzed Hydrophosphonylation of Alkenes with Dialkyl H-Phosphonates Adv. Synth. Catal. 2014, 356, 2703. View at Publisher
  37. Jakubska-Busse, A.; Jasicka-Misiak, I.; Poliwoda, A.; Święczkowska, E.; Kafarski, P., The Chemical Composition of the Floroal Extract of Epipogium aphyllum SW. (Orchidaceae): A Clue for Their Pollination Biology Arch. Biol. Sci., Belgrade 2014, 65, 989. View at Publisher
  38. Deja, S.; Jawień, E.; Jasicka-Misiak, I.; Halama, M.; Wieczorek, P.; Kafarski, P.; Młynarz, P., Rapid determination of ibotenic acid and muscimol in human urine Magn. Reson. Chem. 2014, 52, 711. View at Publisher
  39. Deja, S.; Wieczorek, P. P.; Halama, M.; Jasicka-Misiak, I.; Kafarski, P.; Poliwoda, A.; Mł‚ynarz, P., Do Differences in Chemical Composition of Stem and Cap of Amanita muscaria Fruiting Bodies Correlate with Topsoil Type? PLoS ONE 2014, 9, 104084. View at Publisher
  40. Jewgiński, M.; Latajka, R.; Krężel, A.; Haremza, K.; Makowski, M.; Kafarski, P., Influence of solvents on conformation of dehydropeptides J. Mol. Struct. 2013, 1035, 129. View at Publisher
  41. Forlani, G; Bertazzini, M.; Giberti, S.; Wieczorek, D.; Kafarski, P.; Lipok, J., Sublethal detergent concentrations increase metabolization of recalcitrant polyphosphonates by the cyanobacterium Spirulina platensis Environ. Sci. Pollut. Res. 2013, 20, 3262. View at Publisher
  42. Drąg, M.; Wieczerzak, E.; Pawełczak, M.; Berlicki, Ł.; Grzonka, Z.; Kafarski, P., Toward very potent, non-covalent organophosphonate inhibitors of cathepsin C and related enzymes by 2-amino-1-hydroxy-alkanephosphonates dipeptides. Biochemie 2013, 95, 1640. View at Publisher
  43. Forlani, G.; Berlicki, Ł.; Duò, M.; Dziędzioła, G.; Giberti, S.; Bertazzini, M.; Kafarski, P., Synthesis and Evaluation of Effective Inhibitors of Plant δ1-Pyrroline-5-carboxylate Reductase. J. Agric. Food Chem. 2013, 61, 6792. View at Publisher
  44. Siemieniec, J.; Kafarski, P.; Pluciński, P, Hydrophosphonylation of Nanoparticle Schiff Bases as a Mean for Preparation of Aminophosphonate-Functionalized Nanoparticles Molecules 2013, 18, 8473. View at Publisher
  45. Maciejczyk, E.; Kafarski, P., Mannitol in Amanita muscaria – An osmotic blood–brain barrier disruptor enhancing its hallucinogenic action? Med. Hyphotheses 2013, 81, 766. View at Publisher
  46. Berlicki, Ł.; Bochno, M.; Grabowiecka, A.; Białas, A.; Kosikowska, P.; Kafarski, P., N-Substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases. Amino Acids 2012, 42, 1937. View at Publisher
  47. Forlani, G.; Petrolino, D.; Fusetti M.; Romanini, L.; Nocek, B.; Joachimiak, A.; Berlicki, L.; Kafarski, P., Delta1-Pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo. Amino Acids 2012, 42, 2283. View at Publisher
  48. Jasicka-Misiak, I.; Paliwoda, A.; Dereń, M.; Kafarski, P., Phenolic compounds and abscisic acid as potential markers for the floral origin of two Polish unifloral honeys Food Chem. 2012, 131, 1149. View at Publisher
  49. Górecki, Ł.; Berlicki, Ł.; Mucha, A.; Kafarski, P.; Ślepokura, K.; Rudzińska-Szostak, E., Phosphorylation as a Method of Tuning the Enantiodiscrimination Potency of Quinine – an NMR Study. Chirality 2012, 24, 318. View at Publisher
  50. Gluza, K.; Kafarski, P., Transition State Analogues of Enzymatic Reaction as Potential Drugs Book: Drug Discovery (by InTech) 2012, 325. View at Publisher
  51. Forlani G.; Prearo V.; Wieczorek D.; Kafarski P.; Lipok J., Phosphonate degradation by Spirulina strains: Cyanobacterial biofilters for the removal of anticorrosive polyphosphonates from wastewater Enzyme Microb. Technol. 2011, 48, 199.
  52. Radwan-Olszewska, K.; Palacios, F.; Kafarski, P., Selective Synthesis of α-Fluoro-β-keto- and α-Fluoro-β-aminophosphonates via Electrophilic Fluorination by Selectfluor J. Org. Chem 2011, 76, 1170. View at Publisher
  53. Kowalik, T.; Pietruszka, M.; Jezierska, J.; Matczak-Jon, E; Kafarski, P., Copper(II) complexation by (pyridinyl)aminomethane-1,1-diphosphonic acid derivatives; spectroscopic and potentiometric studies Polyhedron 2011, 30, 1274. View at Publisher
  54. Podstawka-Proniewicz, E.; Andrzejak, M.; Kafarski, P.; Kim, Y.; Proniewicz, L., Vibrational characterization of L-valine phosphonate dipeptides: FT-IR, FT-RS, and SERS spectroscopy studies andDFT calculations J. Raman Spectrosc. 2011, 42, 958. View at Publisher
  55. Brzeziń„ska-Rodak, M.; Klimek-Ochab, M.; Żymań„czyk-Duda E.; Kafarski, P., Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid Molecules 2011, 16, 5896. View at Publisher
  56. Mucha, A.; Kafarski, P.; Berlicki, Ł., Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry. J. Med. Chem. 2011, 54, 5955. View at Publisher
  57. Klimek-Ochab, M.; Brzeziń„ska-Rodak, M.; Żymań„czyk-Duda, E.; Lejczak, B.; Kafarski, P., Comparative study of fungal cell disruption—scope and limitations of the methods. Folia Microbiol. 2011, 56, 469. View at Publisher
  58. Podstawka-Proniewicz, E.; Piergies, N.; Skołuba, D.; Kafarski, P.; Kim, Y.; Proniewicz, L. M., Vibrational Characterization of L-Leucine Phosphonate Analogues: FT-IR, FT-Raman, and SERS Spectroscopy Studies and DFT Calculations J. Phys. Chem. A 2011, 115, 11067. View at Publisher
  59. Gluza, K.; Kafarski, P., Inhibitors of Proteinases as Potential Anti-Cancer Agents Book: Drug Development - A Case Study Based Insight into Modern Strategies 2011, 39. View at Publisher
  60. Jasicka-Misiak, I.; Kafarski, P., Chemiczne markery miodów odmianowych Wiad. Chem. 2011, 65, 821.
  61. Kafarski, P., Chemia a biotechnologia przemysłowa Misja Nauk Chemicznych 2011, 1, 153. View at Publisher
  62. Młynarz, P.; Lasek, B.; Kafarski, P.; Kozik, T.; Schroeder, G., Phosphono peptides and their host-guest chemistry. ESI MS study. Molecular Receptors. Collected Research Papers; Ed. V.I. Rybchenko 2011, 329.
  63. Malinowska, B.; Majewska, P.; Szatkowski, P.; Kafarski, P.; Lejczak, B., Kinetic resolution of (±)-diethyl- and dibenzyl hydroxy(phenyl)methanephosphonates and their acyl derivatives with lipases Biocatalysis and Biotransformation, 2011, 29, 271. View at Publisher
  64. Malinowska B., MajewskaP., Szatkowski P., Kafarski P., Lejczak B., Kinetic resolution of (±)-diethyl- and dibenzyl hydroxy(phenyl)methanephosphonates and their acyl derivatives with lipases Biocatalysis and Biotransformation 2011, 29, 271. View at Publisher
  65. Rudzińska, E.; Dziędzioła, G.; Berlicki, Ł.; Kafarski, P., Enantiodifferentiation of alpha–Hydroxyalkanephosphonic Acids in 31P NMR with Application of alpha–Cyclodextrin as Chiral Discriminating Agent. Chirality 2010, 22, 63. View at Publisher
  66. Occhipinti, A.; Berlicki, Ł.; Giberti, S.; Dziędzioła, G.; Kafarski, P.; Forlani, G., Effectiveness and mode of action of phosphonate inhibitors of plant glutamine synthetase. Pest Manag. Sci. 2010, 66, 51. View at Publisher
  67. Skinner-Adams, T. S.; Stack, C. M.; Trenholme, K. R.; Brown, C. L.; Grembecka, J.; Lowther, J.; Mucha, A.; Drag, M.; Kafarski, P.; McGowan, S.; Whisstock, J. C.; Gardiner, D. L.; Dalton, J. P., Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials. Trends Biochem. Sci. 2010, 35, 53. View at Publisher
  68. McGowan, S.; Oellig, C. A.; Birru, W. A.; Caradoc-Davies, T. T.; Stack, C. M.; Lowther, J.; Skinner-Adams, T.; Mucha, A.; Kafarski, P.; Grembecka, J.; Trenholme, K. R.; Buckle, A. M.; Gardiner, D. L.; Dalton, J. P.; Whisstock, J. C. , Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases. Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 2449. View at Publisher
  69. Matczak-Jon, E.; Kowalik-Jankowska, T.; Ślepokura, K.; Kafarski, P.; Rajewska A., Specificity of the zinc(II), magnesium(II) and calcium(II) complexation by (pyridin-2-yl)aminomethane-1,1-diphosphonic acids and related 1,3-(thiazol-2-yl) and 1,3-(benzothiazol-2-yl) derivatives Dalton Trans. 2010, 39, 1207. View at Publisher
  70. Prokopowicz, M.; Mł‚ynarz, P.; Kafarski, P., Zwiazki metalooorganiczne w syntezie fosfonianów Wiad. Chem. 2010, 64, 1.
  71. Mucha, A.; Drą…g, M.; Dalton, J. P.; Kafarski, P., Metallo-aminopeptidase inhibitors. Biochimie 2010, 92, 1509. View at Publisher
  72. Doskocz, M.; Malinowska, B.; Mł‚ynarz, P.; Lejczak, B.; Kafarski P., Long range phosphorus–phosphorus coupling constants in bis(phosphorylhydroxymethyl)benzene derivatives Tetrahedron Lett. 2010, 51, 3406. View at Publisher
  73. Vassiliou, S.; Kosikowska, P.; Grabowiecka, A.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Computer-aided optimization of phosphinic inhibitors of bacterial ureases. J. Med. Chem. 2010, 53, 5597. View at Publisher
  74. Majewska, P.; Kafarski, P.; Lejczak.B., Enzymatic resolution of ethyl α-hydroxyphosphinates in a modified reaction environment Phosphorus, Sulfur andSilicon 2010, 185, 1915. View at Publisher
  75. Matczak-Jon, E.; Ślepokura, K.; Zierkiewicz, W..; Kafarski, P; Dąbrowska, E., The role of hydrogen bonding in conformational stabilization of 3,5,6- and 3,5-substituted (pyridin-2-yl)aminomethane-1,1-diphosphonic acids and related (pyrimidin-2-yl) derivative J. Mol. Structr. 2010, 980, 182. View at Publisher
  76. Mytnik, E.; Kuryszko, J.; Chmielewska, E.; Kafarski P., Molekularny mechanizm działania bisfosfonianów i ich zastosowanie w praktyce klinicznej Medycyna Weterynaryjna 2010, 66, 307.
  77. Lipok, J.; Wieczorek, D.; Jewgiński, M.; Kafarski, P., Prospects of in vivo 31P NMR method in glyphosate degradation studies in whole cell system Enzyme Microb. Technol. 2009, 44, 11. View at Publisher
  78. Rydzewska, A.; Śšlepkura, K.; Lis, T.; Kafarski, P.; Mł‚ynarz, P., Unexpected formation of hydroxyborazaphosphonic acid in the reaction of (N-benzyl)benzylideneimine-2-boronic acid with diethyl phosphite Tetrahedron Lett. 2009, 50, 132. View at Publisher
  79. McGowan, S.; Porter, C. J.; Lowther. J.; Stack, C. M.; Golding, S. J.; Skinner-Adams, T. S.; Trenholme, K. R.; Teuscher, F.; Donnelly, S. M.; Grembecka, J.; Mucha, A.; Kafarski, P.; Degori, R.; Buckle, A. M.; Gardiner, D. L.; Whisstock, J. C.; Dalton, J. P., Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 2537.
  80. Doskocz, M.; Strupińska, A.; Roszak, S.; Prokopowicz, M.; Koole, L. H.; Kafarski P., Theoretical study of spin-spin coupling across the hydrogen (O-H⋯N) bond in adenosine derivatives J. Mol. Model. 2009, 15, 651. View at Publisher
  81. Ziora, Z.; Kafarski, P., Amidoalkylation of Phosphorus Trichloride with Acetamide and Alkyl Oxocycloalkanecarboxylates Phosphorus, Sulfur, & Silicon 2009, 184, 1047. View at Publisher
  82. Matczak-Jon, E.; Ślepokura, K.; Kafarski, P.; Skrzyńska, I.; Jon, M., Conformational isomers of the [(5-methyl-2-pyridinio)aminomethylene]diphosphonate dianion and [(5-methyl-2-pyridyl)aminomethylene]diphosphonate trianion in salts with 4-aminopyridine and ammonia Acta Cryst. C 2009, 65, 261.
  83. Lejczak, B.; Kafarski, P., Biological Activity of Aminophosphonic Acids and Their Short Peptides Top. Heterocycl. Chem. 2009, 20, 31. View at Publisher
  84. Dąbrowska, E.; Burzyńska, A.; Mucha, A.; Matczak-Jon, E.; Sawka-Dobrowolska, W.; Berlicki, Ł.; Kafarski, P., Insight into the mechanism of three component condensation leading to aminomethylenebisphosphonates. J. Organomet. Chem. 2009, 694, 3806. View at Publisher
  85. Rudzińska, E.; Berlicki, Ł.; Kafarski, P.; Lammerhofer, M.; Mucha, A., Cinchona alkaloids as privileged chiral solvating agents for enantiodiscrimination of N-protected aminoalkanephosphonates - a comparative NMR study. Tetrahedron Asymmetry 2009, 20, 2709. View at Publisher
  86. Prokopowicz, M.; Mł‚ynarz, P.; Kafarski, P, Synthesis of phosphonate derivatives of 2,3-dihydroindene Tetrahedron Lett. 2009, 50, 7314. View at Publisher
  87. Majewska, P.; Doskocz, M.; Lejczak, B.; Kafarski, P., Enzymatic resolution of α-hydroxyphosphinates with two stereogenic centres and determination of absolute configuration of stereoisomers obtained. Tetrahedron Asymm. 2009, 20, 1568. View at Publisher
  88. Dąbrowska, E.; Kafarski, P., Amiomethylenebisphosphonates – a new direction of studies on treatment of osteoporosis OrtopediaTraumatologia i Rehabilitacja 2009, 11, 152.
  89. Forlani, G.; Occhipinti, A.; Berlicki, Ł.; Dziędzioła, G.; Wieczorek, A.; Kafarski, P. , Tailoring the Structure of Aminobisphosphonates to Target Plant P5C Reductase. J. Agric. Food Chem. 2008, 56, 3193. View at Publisher
  90. Mucha, A.; Laemmerhofer, M.; Lindner, W.; Pawełczak, M.; Kafarski, P., Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase. Bioorg. Med. Chem. Lett. 2008, 18, 1550.
  91. Latajka, R.; Krężel, A.; Mucha, A.; Jewgiński, M.; Kafarski, P., Conformational investigations of bis(alpha-aminoalkyl)phosphinic acids and studies of the stability of their complexes with Cu(II). J. Mol. Str. 2008, 877, 64.
  92. Minta, E.; Kafarski, P.; Martinez, J.; Rolland, V., Synthesis of cyclooctapeptides: constraints analogues of the peptidic neurotoxin, ω-agatoxine IVB – an experimental point of view J. Pept. Sci. 2008, 14, 267.
  93. Żymańczyk-Duda, E.; Brzeziń„ska-Rodak, M.; Klimek-Ochab, M.; Latajka, R.; Kafarski, P.; Lejczak, B., Chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethylphosphonate as a valuable product of microbial biotransformation of diethyl 2-oxo-2-phenylethylphosphonate J. Mol. Cat. B 2008, 52, 74.
  94. Lisowski, M.; Latajka, R.; Picur, B.; Lis, T.; Bryndal, I.; Rospenk, M.; Makowski, M.; Kafarski, P., Combined effect of the dehydro-Phe or dehydro-Ala residue and the p-nitroanilide group on a dehydropeptides conformation Biopolymers 2008, 89, 220.
  95. Vassiliou, S.; Grabowiecka, A.; Kosikowska, P.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Design, synthesis and evaluation of novel organophosphorus inhibitors of bacterial ureases. J. Med. Chem. 2008, 51, 5736. View at Publisher
  96. Cunningham, E.; Drą…g, M.; Kafarski, P.; Bell, A., Chemical Target Validation Studies of Aminopeptidase in Malaria Parasites Using alpha-Aminoalkylphosphonate and Phosphonopeptide Inhibitors Antimicrob. Agents Chemother. 2008, 52, 3221. View at Publisher
  97. Forlani, G.; Pavan, M.; Gramek, M.; Kafarski, P.; Lipok, J., Biochemical Bases for a Widespread Tolerance of Cyanobacteria to the Phosphonate Herbicide Glyphosate Plant Cell Physiol. 2008, 49, 443.
  98. Podstawka, E.; Andrzejak M.; Kafarski, P.; Proniewicz, L. M., Comparison of adsorption mechanism on colloidal silver surface of alafosfalin and its analogs J. Raman Spectrosc. 2008, 39, 1239.
  99. Jaskula, B.; Kafarski, P.; Aerts, G.; De Cooman, L., A Kinetic Study on the Isomerization of Hop alpha-Acids J. Agric. Food Chem. 2008, 56, 6408.
  100. Mł‚ynarz, P.; Olbert-Majkut, A.; Śliwiń„ska, S.; Schroeder, G., Bań„kowski, B. Kafarski, P., 1,4-Phenylene-di(N-L-alanylaminomethylphosphonate) a new diaminophosphonate peptide receptor for lysine and arginine J. Mol. Struct. 2008, 873, 173.
  101. Mł‚ynarz, P.; Czernicka, A.; Rydzewska, A,; Schroeder, G.; Kafarski, P., Tetra-2-methoxyethyl phenylene-1,4-di(benzyloaminomethanephosphonate) a new ligand for metal ions and amino acids. Electrospray ionization mass spectrometric and NMR studies J. Mol. Struct. 2008, 875, 130.
  102. Podstawka, E.; Kafarski, P.; Proniewicz, L. M., Effect of an aliphatic spacer group on the adsorption mechanism of phosphonodipeptides containing N-terminal glycine on the colloidal silver surface J. Raman. Spectrosc. 2008, 39, 1396.
  103. Latajka, R.; Jewginski, M.; Makowski, M., Pawełczak, M.; Huber, T.; Sewald, N.; Kafarski, P., Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C J. Pept. Sci. 2008, 14, 1084. View at Publisher
  104. Podstawka, E.; Kafarski, P.; Proniewicz, L. M., Structural Properties of L-X-L-Met-L-Ala Phosphonate Tripeptides: A Combined FT-IR, FT-RS, and SERS Spectroscopy Studies and DFT Calculations J. Phys. Chem. A 2008, 112, 11744.
  105. Podstawka, E.;Kafarski, P;Proniewicz, L. M., Effect of an aliphatic spacer group on the adsorption mechanism on the colloidal silver surface of L-proline phosphonodipeptides J. Raman Spectrosc. 2008, 39, 1726.
  106. Rudzińska, E.; Poliwoda, A.; Berlicki, Ł.; Mucha, A.; Dżygiel, P.; Wieczorek, P.P.; Kafarski, P., Enantiodifferentiation of N-benzyloxycarbonylaminophosphonic and phosphinic acids and their esters using cyclodextrins by means of capillary electrophoresis. J. Chromat. A 2007, 1138, 284. View at Publisher
  107. Berlicki, Ł.; Grembecka, J.; Dyguda-Kazimierowicz, E.; Kafarski, P.; Sokalski, W.A., From inhibitors of LAP to inhibitors of PAL. Lessons from Molecular Modeling and Experiment Interface. in Molecular Materials with Specific Interactions (Ed. W. A. Sokalski) 2007, 365.
  108. Stack, C. M.; Lowther, J.; Cunningham, E.; Donnelly, S.; Gardiner, D. L.; Trenholme, K. R.; Skinner-Adams, T. S.; Teuscher, F.; Grembecka, J.; Mucha, A.; Kafarski, P.; Lua, L.; Bell, A.; Dalton, J. P., Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development. J. Biol. Chem. 2007, 282, 2069.
  109. Forlani, G.; Giberti, S.; Berlicki, Ł.; Petrollino, D.; Kafarski, P., Plant P5C reductase as a new target for aminomethylenebisphosphonates. J. Agric. Food Chem. 2007, 55, 4340. View at Publisher
  110. Rudzińska, E.; Berlicki, Ł.; Mucha, A.; Kafarski, P., Analysis of pD Dependent Complexation of N-Benzyloxycarbonylaminophosphonic Acids by a-Cyclodextrin. Enantiodifferentation of Phosphonic Acid pKa V alues Chirality 2007, 19, 764. View at Publisher
  111. Młynarz, P.; Rudzińska, E.; Berlicki, Ł.; Kafarski, P., Organophosphorus supramolecular chemistry. Part 2. Organophosphorus receptors Curr. Org. Chem. 2007, 11, 1593.
  112. Rudzińska, E.; Berlicki, Ł.; Mucha, A.; Kafarski, P., Chiral discrimination of ethyl and phenyl N-benzyloxycarbonylaminophosphonates by cyclodextrins. Tetrahedron Asymmetry 2007, 18, 1579. View at Publisher
  113. Berlicki, Ł.; Mucha, A.; Kafarski, P., A mild and convenient oxidation of H-phosphinic acids. Pol. J. Chem. 2007, 81, 1959.
  114. Vassiliou, S.; Xeilari, M.; Yiotakis, A.; Grembecka, J.; Pawelczak, M.; Kafarski, P.; Mucha, A., A synthetic method for diversification of the P1 ' substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1 ' binding pockets of leucine aminopeptidases. Bioorg. Med. Chem. 2007, 15, 3187.
  115. Teuscher, F.; Lowther, J.; Skinner-Adams, T.S.; Spielmann, T.; Dixon, M.W.A.; Stack, C.M.; Donnelly, S.; Mucha, A.; Kafarski, P.; Vassiliou, S.; Gardiner, D.L.; Dalton, J.P.; Trenholme, K.R., The M18 Aspartyl Aminopeptidase of the Human Malaria Parasite Plasmodium falciparum. J. Biol. Chem. 2007, 282, 30817.
  116. Skinner-Adams, T. S.; Lowther, J.; Teuscher, F.; Stack, C. M.; Grembecka, J.; Mucha, A.; Kafarski, P.; Trenholme, K. R.; Dalton, J. P.; Gardiner, D. L., Identification of Phosphinate Dipeptide Analog Inhibitors Directed against the Plasmodium falciparum M17 Leucine Aminopeptidase as Lead Antimalarial Compounds. J. Med. Chem. 2007, 50, 6024.
  117. Młynarz, P.; Jewgiński, M.; Sliwinska, S.; Latajka, R.; Schroeder, G.; Kafarski, P., "Twin" phosphorous atoms of tetraethyl 2-methyl-piperyd-1-ylmethylenebisphosphonates Heteroatom Chem. 2007, 18, 774. View at Publisher
  118. Podstawka, E.; Kudelski, A.; Kafarski, P.; Proniewicz L.M., Influence of aliphatic spacer group on adsorption mechanisms of phosphonate derivatives of L-phenylalanine: Surface-enhanced Raman, Raman, and infrared studies Surface Sci. 2007, 601, 4586.
  119. Gałęzowska, J.; Szyrwiel, Ł.; Młynarz, P.; Śšliwiń„ska, S.; Kafarski, P.; Kozł‚owski, H., Coordination abilities of difunctional, diaminophosphonic acid and its dipeptides towards Cu(II) ions Polyhedron 2007, 26, 4287.
  120. Lipok, J, Owsiak, T,. Młynarz, P. ; Forlani, G. Kafarski P., Phosphorus NMR as a tool to study mineralization of organophosphonates—The ability of Spirulina spp. to degrade glyphosate Enzyme Microb. Technol. 2007, 41, 286.
  121. Berlicki, Ł.; Kafarski, P., Computer-aided analysis of the interactions of glutamine synthetase with its inhibitors. Bioorg. Med. Chem. 2006, 14, 4578. View at Publisher
  122. Forlani, G.; Obojska, A.; Berlicki, Ł.; Kafarski, P., Phosphinothricin Analogues as Inhibitors of Plant Glutamine Synthetases. J. Agric. Food Chem. 2006, 54, 796. View at Publisher
  123. Biał‚as, A.; Grembecka, J.; Krowarsch, D.; Otlewski, J.; Potempa, J.; Mucha, A., Exploring the Sn Binding Pockets in Gingipains by Newly Developed Inhibitors: Structure-Based Design, Chemistry and Activity. J. Med. Chem. 2006, 49, 1744.
  124. Matczak-Jon, E.; Slepokura, K.; Kafarski, P., Solid state and solution behaviour of N-(2-pyridyl)- and N-(4-methyl-2-pyridyl)aminomethane-1,1-diphosphonic acids. J. Mol. Struct. 2006, 782, 81.
  125. Lyapchenko, N.; Schroeder, G.; Przybylski, P.; Burzynska, A.; Kafarski, P.; Brzezinski, B., Mass spectrometric and PM5 study of some piperidine-N-methyldiphosphonic acids and their complexes with alkali cations. J. Mol. Struct. 2006, 782, 183.
  126. Brzezinska-Rodak, M.; Zymanczyk-Duda, E.; Klimek-Ochab, M.; Kafarski, P.; Lejczak, B., A simple and green procedure for the microbial effective synthesis of 1-phenylethyl alcohol in both enantiomeric forms. Biotech. Lett. 2006, 28, 511.
  127. Matczak-Jon, E.; Slepokura, K.; Kafarski, P., [(5-Bromopyridinium-2-ylamino)(phosphono)methyl]phosphonate. Acta Crystallogr. C 2006, 62, 132.
  128. Berlicki, Ł.; Rudzińska, E.; Młynarz, P.; Kafarski, P., Organophosphorus supramolecular chemistry. Part 1. Receptors for organophosphorus compounds. Curr. Org. Chem. 2006, 10, 2285.
  129. Latajka, R.; Makowski, M.; Jewginski, M.; Pawelczak, M.; Koroniak, H.; Kafarski, P., Peptide p-nitrophenylanilides containing (E)-dehydrophenylalanine - synthesis, structural studies and evaluation of their activity towards cathepsin C. New J. Chem. 2006, 30, 1009. View at Publisher
  130. Mucha, A.; Kunert, A.; Grembecka, J.; Pawelczak, M.; Kafarski, P., A phosphonamidate containing aromatic N-terminal amino group as inhibitor of leucine aminopeptidase-design, synthesis and stability. Eur. J. Med. Chem. 2006, 41, 768.
  131. Matczak-Jon, E.; Kurzak, B.; Kafarski, P.; Wozna, A., Coordination abilities of piperyd-1-yl-methane-1,1-diphosphonic acids towards zinc(II), magnesium(II) and calcium(II): Potentiometric and NMR studies. J. Inorg. Biochem. 2006, 100, 1155.
  132. Preinerstorfer, B.; Lubda, D.; Mucha, A.; Kafarski, P.; Lindner, W.; Lämmerhofer, M., Stereoselective separations of chiral phosphinic acid pseudodipeptides by CEC using silica monoliths modified with an anion-exchange-type chiral selector. Electrophoresis 2006, 27, 4312.
  133. Jagiełło, M.; Minta, E.; Chojnacka, K.; Kafarski, P., Mode of Biosorption of Chromium(III) by Spirulina Species Cells from Aqueous Solutions Water Environment Research 2006, 78, 740.
  134. Majewska, P.; Kafarski, P.; Lejczak, B.; Bryndal, I.; LIs, T., An approach to the synthesis and assignment of the absolute configuration of all enantiomers of ethyl hydroxy(phenyl)methane(P-phenyl)phosphinate Tetrahedron: Asymm. 2006, 17, 2697.
  135. Majewska, P.; Kafarski, P.; Lejczak, B., Simple and effective method for the deracemization of ethyl 1-hydroxyphosphinate using biocatalysts with lipolytic activity Tetrahedron: Asymmetry 2006, 17, 2870.