Paweł Lenartowicz

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Hobby: music and acoustic guitar playing (fingerstyle).

e-mail: pawel.lenartowicz@pwr.wroc.pl


Education

2016 - PhD in Chemistry, Faculty of Chemistry, Opole University, Doctoral thesis “Synthesis of peptide inhibitors of cathepsin C”, supervisor: Prof. Paweł Kafarski.

2010 - MSc in Chemistry, Faculty of Chemistry, Opole University, Master thesis “Biodegradation of phosphonate compounds by Aspergillus terreus”, supervisor: Prof. Paweł Kafarski.


Employment

2017 – to date, Assistant, Department of Bioorganic Chemistry, Wrocław University of Science and Technology

2016 – 2017, Chemist, Faculty of Chemistry, Opole University


Fellowships

Belgium, KaHo Sint-Lieven, supervisor: Leen Van Houdt, Erasmus program, 2009 (5 months)


Research interests

The current research refers to the synthesis of peptides containing dehydroamino acid residues and structural modifications of their structure. Synthesis of biological active compounds especially inhibitors of enzymes.


Publications

  1. Lenartowicz, P.; Makowski, M.; Oszywa, B.; Haremza, K.; Latajka, R.; Pawełczak, M.; Kafarski, P., Addition of thiols to the double bond of dipeptide C-terminal dehydroalanine as a source of new inhibitors of cathepsin C. Biochimie 2017. DOI: 10.1016/j.biochi.2017.05.011
  2. Lenartowicz, P.; Dziuk, B.; Zarychta, B.; Makowski, M.; Kafarski, P., Michael additions to double bonds of esters of N-protected (S)-phenylalanyldehydroalanine (X-(S)-Phe-ΔAla-OMe) and its phosphonic acid counterpart (X-(S)-Phe-ΔAla-PO(OEt)2). Phosphorus, Sulfur, Silicon Relat. Elem. 2017, 192, 706-712. DOI: 10.1080/10426507.2017.1308933
  3. Makowski, M.; Lenartowicz, P.; Oszywa, B.; Jewgiński, M.; Pawełczak, M.; Kafarski, P., Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C. Med. Chem. Res. 2015, 24, 3157-3165. DOI: 10.1007/s00044-015-1366-0
  4. Lenartowicz, P.; Makowski, M.; Zarychta, B.; Ejsmont, K., Crystal structure of N-(tert-butoxycarbonyl)phenylalanyldehydroalanine isopropyl ester (Boc-Phe-ΔAla-OiPr). Acta Crystallogr. E Struct. Rep. Online 2014, 70, 599-602. DOI: 1 0.1107/S1600536814025197
  5. Lenartowicz, P.; Makowski, M.; Zarychta, B.; Ejsmont, K., Crystal structure of N-(tert-butoxycarbonyl)glycyl-(Z)-β-bromodehydroalanine methyl ester [Boc-Gly-(β-Br)(Z)ΔAla-OMe]. Acta Crystallogr. E Struct. Rep. Online 2014, 70, 596-5 98. DOI: 10.1107/S1600536814025677
  6. Lenartowicz, P.; Kafarski, P.; Lipok, J., The overproduction of 2,4-DTBP accompanying to the lack of available form of phosphorus during the biodegradative utilization of aminophosphonates by Aspergillus terreus. Biodegradation 2014, 26, 65-76. DOI: 10.1007/s10532-014-9716-z
  7. Lenartowicz, P.; Makowski, M., Inhibitory katepsyny C. (red. Koroniak, H.; Barciszewski, J.) Na pograniczu chemii i biologii, tom XXVII, Wydawnictwo Naukowe UAM, Poznań 2011, 253-261.