Piotr Młynarz

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Mlynarz.jpg

Married (1997); sons: Jakub (2001), Karol (2009).

Education: M.S. Faculty of Chemistry, University of Wrocław. Ph.D. Faculty of Chemistry, University of Wrocław.

Hobby: cooking, sport.

Phone: (48-71)3203616,

Fax: (48-71)3284064

Address: Department of Bioorganic Chemistry Wrocław University of Technology Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

E-mail: piotr.mlynarz@pwr.wroc.pl


Research interests

  • The "host-guest" supramolecular chemistry.
  • Designing by use molecular dynamics and synthesis of aminophosphonate synthetic receptors for biologically important molecules.
  • Molecular and chiral recognition's of biological important molecules eg: aminoacids residues.
  • Chelating properties of aminophosphonians towards metal ions.
  • The enatiomeric separations of aminophosphonians by use complexations properties of metal ions.
  • Metebolomics studies


Awards

  • 2008 - Nagroda Rektora Politechniki Wrocławskiej
  • 2005 - The Foundation for Polish Science - National Post-Doc Position;
  • 2004 - The Foundation for Polish Science - Scholarship;
  • 2004 - Award of Dean of Faculty of Chemistry, Wrocław University of Technology;
  • 2003 - The Foundation for Polish Science - Scholarship;
  • 2003 - Minister of National Education Award;
  • 2001 - Award of Dean of Faculty of Chemistry, University of Wrocław.


Foreign trainee periods

  • 07.2010, 7 days; Uniwersity of Trieste, Italy
  • 08.2007, 6 days; University of Siana, Italy
  • 04.2006, 14 days; University of Siana,Italy
  • 05.2005, 5 days; Uniwersity of Catania, Italy
  • 02.2002 - 06.2002; associate researcher Department of Chemistry, University of Siena, Italy
  • 07.2001, 4 days; SAPIO, NMR-training course, CERM Florencja, Italy
  • 06.2001 - 09.2001; associate researcher Department of Chemistry, University of Siena, Italy
  • 05.2000, 14 days; EU-ESF Practical Training Course Inorganic Biology Louvain-la-Neuve, Belgium
  • 11.1999; NMR-trainee, University of Siena, Italy
  • 01.1999; NMR-trainee, University of Siena, Italy
  • 01-05.1996; European Community Project "Tempus", Faculty of Chemistry, University of Leiden, Holland

Publications

  1. Ząbek A, Junka A, Szymczyk P, Wojtowicz W, Klimek-Ochab M, Młynarz P, Metabolomics analysis of fungal biofilm development and of arachidonic acid-based quorum sensing mechanism Journal of Basic Microbiology 2017, 9999, 1. View at Publisher
  2. Ząbek A, Klimek-Ochab M, Jawień E, Młynarz P, Biodiversity in targeted metabolomics analysis of filamentous fungal pathogens by 1H NMR-based studies World J Microbiol Biotechnol 2017, 33, 132. View at Publisher
  3. Ząbek, A.; Swierkot, J; Malak, A.; Zawadzka, I.; Deja, S.; Bogunia-Kubik, K.; Mlynarz, P. , Application of H-1 NMR-based serum metabolomic studies for monitoring female patients with rheumatoid arthritis J. Pharm. Biomed. Anal. 2016, 117, 544. View at Publisher
  4. Orczyk-Pawiłowicz, M.; Jawień, E.; Deja, S.; Hirnle, L.; Ząbek, A.; Młynarz, P., Metabolomics of Human Amniotic Fluid and Maternal Plasma furing Normal Pregnancy PLoS One 2016, 11, 1. View at Publisher
  5. Deiasna, M.; Pokładek, Z.; Olesiak-Bańska, J.; Młynarz, P.; Samoć, M.; Matczyszyn., K., Photochromic switching of the DNA helicity induced by azobenzene derivatives Sci. Rep. 2016, 6, 1. View at Publisher
  6. Dobosz, A.; Spychała, J.; Ptak, T.; Chmielewska, E.; Maciejewska, G.; Kafarski, P.; Młynarz, P. , Electrochemical and spectroscopic investigations of selected N-heteroalkylaminomethylenebisphosphonic acids with Pb(II) ions Coord. Chem. Rev. 2016, 327-328, 271. View at Publisher
  7. Chmielewska, E.; Miszczyk, P.; Kozłowska, J.; Prokopowicz, M.; Młynarz, P.; Kafarski. P., Reaction of benzolactams with triethyl phosphite prompted by phosphoryl chloride affords benzoannulated monophosphonates instead of expected bisphoshonates J. Organomet. Chem. 2015, 785, 84. View at Publisher
  8. Dobosz, A.; Spychała, J.; Ptak, T.; Maciejewska, G.; Chmielewska, E.; Kafarski, P.; Młynarz, P., Interactions of N-heteroalkylaminomethylenebisphosphonic acids with Cd(II) ions: Electrochemical and spectroscopic investigations Inorg. Chim. Acta 2015, 435, 82. View at Publisher
  9. Zabek, A; Stanimirova, I; Deja, S; Barg, W; Kowal, A; Korzeniewska, A; Orczyk-Pawilowicz, M; Baranowski, D; Gdaniec, Z; Jankowska, R; Mlynarz, P, Fusion of the H-1 NMR data of serum, urine and exhaled breath condensate in order to discriminate chronic obstructive pulmonary disease and obstructive sleep apnea syndrome METABOLOMICS 2015, 11, 1563. View at Publisher
  10. Zabek, A.; Nagaj, J.; Grabowiecka, A.; Dworniczek, E.; Nawrot, U.; Młynarz, P.; Jeżowska-Bojczuk, M., Activity of fluconazole and its Cu(II) complex towards Candida species Med. Chem. Res. 2015, 24, 2005. View at Publisher
  11. Jawień, E.; Ząbek, A.; Deja S.; Łukaszewicz, M.; Młynarz, P., 1H NMR-based metabolic profiling for evaluating poppy seed rancidity and brewing Chem. Mol. Biol. Lett. 2015, 20, 752. View at Publisher
  12. Górny vel Górniak, M.; Czernicka, A.; Mł‚ynarz, P., Balcerzak, W.; Kafarski, P., Synthesis of fluorescent (benzyloxycarbonylamino)(aryl)methylphosphonates Beilstein J. Org. Chem. 2014, 10, 741. View at Publisher
  13. Dawiskiba, T.; Deja, S.; Mulak, A.; Ząbek, A.; Jawień, E.; Pawełka, D.; Banasik, M.; Mastalerz-Migas, A.; Balcerzak, W.; Kaliszewski, K.; Skóra, J.; Barć, P.; Korta, K.; Pormańczuk, K.; Szyber, P.; Litarski, A.; Młynarz, P., Serum and urine metabolomic fingerprinting in inflammatory bowel diseases - 1H NMR-based study World J. Gastroenterol. 2014, 20, 163. View at Publisher
  14. Ząbek, A.; Nagaj, J.; Grabowiecka, A.; Dworniczek, E.; Nawrot, U.; Młynarz, P.; Jezowska-Bojczuk, M., Activity of fluconazole and its Cu(II) complex towards Candida species Med. Chem. Res. 2014, 1. View at Publisher
  15. Deja, S.; Porebska, I.; Kowal, A.; Zabek, A.; Barg, W.; Pawelczyk, K.; Stanimirova, I.; Daszykowski, M.; Korzeniewska, A.; Jankowska, R.; Mlynarz, P., Metabolomics provide new insights on lung cancer staging and discrimination from chronic obstructive pulmonary disease. J. Pharm. Biomed. Anal. 2014, 100, 369. View at Publisher
  16. Deja, S.; Jawień, E.; Jasicka-Misiak, I.; Halama, M.; Wieczorek, P.; Kafarski, P.; Młynarz, P., Rapid determination of ibotenic acid and muscimol in human urine Magn. Reson. Chem. 2014, 52, 711. View at Publisher
  17. Deja, S.; Wieczorek, P. P.; Halama, M.; Jasicka-Misiak, I.; Kafarski, P.; Poliwoda, A.; Mł‚ynarz, P., Do Differences in Chemical Composition of Stem and Cap of Amanita muscaria Fruiting Bodies Correlate with Topsoil Type? PLoS ONE 2014, 9, 104084. View at Publisher
  18. Jawien E., Korczynski M., Opalinski S., Mlynarz P., Use of NMR techniques in evaluation of the egg raw material for food industry PRZEMYSL CHEMICZNY 2014, 1616.
  19. Ptak, T.; Młynarz, P.; Dobosz, A.; Rydzewska, A.; Prokopowicz, M., Potentiometric and NMR complexation studies of phenylboronic acid PBA and its aminophosphonate analog with selected catecholamines J. Mol. Struct. 2013, 1040, 59. View at Publisher
  20. Deja S., Dawiskiba T., Balcerzak W., Orczyk-Pawiłowicz M., Głód M., Pawełka D., Młynarz P., Follicular adenomas exhibit a unique metabolic profile.1H NMR studies of thyroid lesions PLoS ONE 2013, 8, 1. View at Publisher
  21. Junka A.F., Deja S., Smutnicka D., Szymczyk P., Ziółkowski G., Bartoszewicz M., Młynarz P., Differences in metabolic profiles of planktonic and biofilm cells in Staphylococcus aureus - 1H nuclear magnetic resonance search for candidate biomarkers Acta Biochimica Polonica 2013, 60, 701. View at Publisher
  22. Deja S., Barg E., Młynarz P., Basiak A., Willak-Janc E., 1H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values Journal of Pharmaceuticals and Biomedical Analysis 2013, 82, 43. View at Publisher
  23. Calderisi M., Vivi A., Mlynarz P., Tassin M., Banasik M., Dawiskiba T., Carmellini M., Using metabolomics to monitor kidney transplantation patients by means of clustering to spot anomalous patient behavior Transplantation Proceedings 2013, 45, 1511. View at Publisher
  24. Ząbek A., Młynarz P., Ocena przydatności badań metabolomicznych w diagnostyce zakażeń wirusowych Forum Zakażeń 2013, 4, 325.
  25. Młynarz P., Barg W., Deja S., Jankowska R., Application of metabolomic in COPD diagnosing Polski Merkuriusz Lekarski 2012, 33, 207.
  26. Młynarz, P.; Rydzewska, A.; Pokładek, Z., Preparation of a novel group of hybrid compounds N-benzyl aminoboronbenzylphosphonic and N,N′-ethylenedi(aminoboronbenzylphosphonic) acids J. Organomet. Chem. 2011, 696, 457. View at Publisher
  27. Szczepanik, W.; Młynarz, P.; Stefanowicz, P.; Kucharczyk-Klaminska, M.; D’Amelio, N.; Olbert-Majkut, A.; Staszewska, A.; Ratajska, M.; Szewczuk, Z.; Jezowska-Bojczuk, M., Structural studies of Cu(II) binding to the novel peptidyl derivative of quinoxaline: N-(3-(2,3-di(pyridin-2-yl)quinoxalin-6-yl)alanyl)glycine Polyhedron 2011, 30, 9.
  28. Młynarz, P.; Ptak, T.; Czernicka, A.; Pankiewicz, R.; Gluza, K.; Zarzeczanska, D., Bis{phenyl[di(methoxyethyloxy)phosphoryl]methyl}amine as a new ligand for metal ions and cationic organic molecules J. Mol. Struct. 2011, 991, 18.
  29. Prokopowicz, M.; Mł‚ynarz, P.; Kafarski, P., Zwiazki metalooorganiczne w syntezie fosfonianów Wiad. Chem. 2010, 64, 1.
  30. Doskocz, M.; Malinowska, B.; Mł‚ynarz, P.; Lejczak, B.; Kafarski P., Long range phosphorus–phosphorus coupling constants in bis(phosphorylhydroxymethyl)benzene derivatives Tetrahedron Lett. 2010, 51, 3406. View at Publisher
  31. Gałęzowska, J.; Janicki, R.; Kozlowski, H.; Mlynarz, P.; Szyrwiel, L., Unusual coordination behaviour of a phosphonate- and pyridine-containing ligand in a stable Eur. J. Inorg. Chem. 2010, 11, 1696.
  32. Rydzewska, A.; Śšlepkura, K.; Lis, T.; Kafarski, P.; Mł‚ynarz, P., Unexpected formation of hydroxyborazaphosphonic acid in the reaction of (N-benzyl)benzylideneimine-2-boronic acid with diethyl phosphite Tetrahedron Lett. 2009, 50, 132. View at Publisher
  33. Prokopowicz, M.; Mł‚ynarz, P.; Kafarski, P, Synthesis of phosphonate derivatives of 2,3-dihydroindene Tetrahedron Lett. 2009, 50, 7314. View at Publisher
  34. Młynarz, P.; Rydzewska, A.; Śliwinska, S.; Szymczyk, M., The Aza alpha-aminophosphonate macrocycle Phosphorus, Sulfur and Silicon and Rel. Elem. 2009, 184, 1496. View at Publisher
  35. Gałęzowska J., Kafarski P., Kozlowski H., Mlynarz P., Nurchi V., Pivetta T. , N,N '-Ethylenediaminobis(benzylphosphonic acids) as a potent class of chelators for metal ions Inorg. Chim Acta 2009, 707.
  36. Mł‚ynarz, P.; Czernicka, A.; Rydzewska, A,; Schroeder, G.; Kafarski, P., Tetra-2-methoxyethyl phenylene-1,4-di(benzyloaminomethanephosphonate) a new ligand for metal ions and amino acids. Electrospray ionization mass spectrometric and NMR studies J. Mol. Struct. 2008, 875, 130.
  37. Rydzewska, A.; Młynarz, P., "Wybrane własciwosci kwasów boronowych i fosfonowych" Na pograniczu chemii i biologii 2008, 255.
  38. Młynarz, P., Olbert-Majkut A., Śliwińska S., Schroeder G., Bańkowski, B., Kafarski, P., 1,4-Phenylene-di(N-L-alanylaminomethylphosphonate) a new diaminophosphonate peptide receptor J. Mol. Struct. 2008, 873, 173.
  39. Karavelas T., Malandrinos G, Hadjiliadis N., Mlynarz P., Kozlowski H, Barsam H., Butler I., Coordination properties of Cu(II) and Ni(II) ions towards the C-terminal peptide fragment -TYTEHA- of histone H4 J. Chem. Soc., Dalton Trans. 2008, 1215.
  40. Młynarz, P.; Rudzińska, E.; Berlicki, Ł.; Kafarski, P., Organophosphorus supramolecular chemistry. Part 2. Organophosphorus receptors Curr. Org. Chem. 2007, 11, 1593.
  41. Młynarz, P.; Jewgiński, M.; Sliwinska, S.; Latajka, R.; Schroeder, G.; Kafarski, P., "Twin" phosphorous atoms of tetraethyl 2-methyl-piperyd-1-ylmethylenebisphosphonates Heteroatom Chem. 2007, 18, 774. View at Publisher
  42. Gałęzowska, J.; Szyrwiel, Ł.; Młynarz, P.; Śšliwiń„ska, S.; Kafarski, P.; Kozł‚owski, H., Coordination abilities of difunctional, diaminophosphonic acid and its dipeptides towards Cu(II) ions Polyhedron 2007, 26, 4287.
  43. Lipok, J, Owsiak, T,. Młynarz, P. ; Forlani, G. Kafarski P., Phosphorus NMR as a tool to study mineralization of organophosphonates—The ability of Spirulina spp. to degrade glyphosate Enzyme Microb. Technol. 2007, 41, 286.
  44. Młynarz, P.; Czernicka, A.; Rydzewska, A.; Kafarski, P., "Nowoczesna diagnostyka medyczna. Chipy i matryce molekularne" Receptory supramolekularne 2007, 101.
  45. Berlicki, Ł.; Rudzińska, E.; Młynarz, P.; Kafarski, P., Organophosphorus supramolecular chemistry. Part 1. Receptors for organophosphorus compounds. Curr. Org. Chem. 2006, 10, 2285.
  46. Sokolov, F.D.; Zabirov, N.G.; Yamalieva, L.N.; Shtyrlin, V.G.; Garipov, R.R.; Brusko, V.V.; Verat, A.Yu.; Baranov, S.V.; Mlynarz, P.; Glowiak, T.; Kozlowski, H., Coordination diversity of N-phosphoryl-N′-phenylthiourea (LH) towards CoII, NiII and PdII cations: Crystal structure of ML2-N,S and ML2-O,S chelates. Inorg. Chim. Acta 2006, 359, 2087.
  47. Karavelas, T.; Mylonas, M.; Malandrinos, G.; Plakatouras, J.C.; Hadjiliadis, N.; Mlynarz, P.; Kozlowski, H., Coordination properties of Cu(II) and Ni(II) ions towards the C-terminal peptide fragment -ELAKHA- of histone H2B. J. Inorg. Biochem. 2005, 99, 606.
  48. Jasicka-Misiak, I.; Lipok, J.; Nowakowska, E.M.; Wieczorek, P.; Młynarz, P.; Kafarski, P., Antifungal activity of the carrot seed oil and its major sesquiterpene compounds. Z. Naturforsch 2004, 59, 791.
  49. D'Amelio, N.; Gaggelli, E.; Mlynarz, P.; Molteni, E.; Valensin, G.; Lubitz, W., , NMR structural model of the interaction of herbicides with the photosynthetic reaction center from Rhodobacter sphaeroides. CHEMBIOCHEM 2004, 5, 1237.
  50. Ganadu, M.L.; Aru, M.; Mura, G.M.; Coi, A.; Mlynarz, P.; Kozlowski, H., Effects of divalent metal ions on the alpha beta-crystallin chaperone-like activity: spectroscopic evidence for a complex between copper(II) and protein. J. Inorg. Biochem. 2004, 98, 1103.
  51. Conato, C.; Kozlowski, H.; Swiatek-Kozlowska, J.; Mlynarz, P.; Remelli, M.; Silvestri, S., Formation equilibria of nickel complexes with glycyl-histidyl-lysine and two synthetic analogues. J. Inorg. Biochem. 2004, 98, 153.
  52. Conato, C.; Kamysz, W.; Kozlowski, H.; Luczkowski, M.; Mackiewicz, Z.; Mancini, F.; Mlynarz, P.; Remelli, M.; Valensin, D.; Valensin, G., Cu-II ion coordination to an unprotected pentadecapeptide containing two His residues: Competition between the terminal amino and the side-chain imidazole nitrogen donors. Eur. J. Inorg. Chem. 2003, 2003, 1694.
  53. D'Amelio, N.; Gaggelli, E.; Gajewska, A.; Kochman, H.; Kochman, K.; Kozlowski, H.; Latajka, Z.; Mlynarz, P.; Panek, J.; Valensin, G., Structural analysis and sheep pituitary receptor binding of GnRH and its complexes with metal ions. J. Inorg. Biochem. 2003, 94, 28.
  54. Conato, C.; Kamysz, W.; Kozlowski, H.; Luczkowski, M.; Mackiewicz, Z.; Mlynarz, P.; Remelli, M.; Valensin, D.; Valensin, G., Cu(II) ion coordination to the pentadecapeptide model of the SPARC copper-binding site. J. Chem. Soc. Dalton Trans. 2002, 3939.
  55. Conato, C.; Kozlowski, H.; Mlynarz, P.; Pulidori, F.; Remelli, M., Copper and nickel complex-formation equilibria with Lys-Gly-His-Lys, a fragment of the matricellular protein SPARC. Polyhedron 2002, 21, 1469.
  56. Mlynarz, P.; Valensin, D.; Kociolek, K.; Zabrocki, J.; Olejnik, J.; Kozlowski, H., Impact of the peptide sequence on the coordination abilities of albumin-like tripeptides towards Cu2+, Ni2+ and Zn2+ ions. Potential albumin-like peptide chelators. New J. Chem. 2002, 26, 264.
  57. Lipinski, R.; Chruscinski, L.; Mlynarz, P.; Boduszek, B.; Kozlowski, H., Coordination abilities of amino-phosphonate derivatives of pyridine. Inorg. Chim. Acta 2001, 322, 157.
  58. Conato, C.; Gavioli, R.; Guerrini, R.; Kozlowski, H.; Mlynarz, P.; Pasti, C.; Pulidori, F.; Remelli, M., Copper complexes of glycyl-histidyl-lysine and two of its synthetic analogues: chemical behaviour and biological activity. BBA-General Subj. 2001, 1526, 199.
  59. Krezel, A.; Lesniak, W.; Jezowska-Bojczuk, M.; Mlynarz, P.; Brasun, J.; Kozlowski, H.; Bal, W., Coordination of heavy metals by dithiothreitol, a commonly used thiol group protectant J. Inorg. Biochem. 2001, 84, 77.
  60. Mlynarz, P.; Valensin, D.; Kozlowski, H.; Kowalik-Jankowska, T.; Otlewski, J.; Valensin, G.; Gaggelli, N., Co-ordination ability towards Cu-II of the 29-amino acid residue trypsin inhibitor of squash and two of its analogues. J. Chem. Soc. Dalton Trans. 2001, 645.
  61. Remelli, M.; Conato, C.; Agarossi, A.; Pulidori, F.; Mlynarz, P.; Kozlowski, H., Copper complexes of dipeptides with L-Lys as C-terminal residue: a thermodynamic and spectroscopic study. Polyhedron 2000, 19, 2409.
  62. Chruscinski, L.; Mlynarz, P.; Malinowska, K.; Ochocki, J.; Boduszek, B.; Kozlowski, H., Methylphosphonate, hydroxymethylphosphonate and aminomethylphosphonate ligands containing pyridine, pyrazole or imidazole side chains: the coordination abilities towards Cu(II) ions. Inorg. Chim. Acta 2000, 303, 47.
  63. Mlynarz, P.; Gaggelli, N.; Panek, J.; Stasiak, M.; Valensin, G.; Kowalik-Jankowska, T.; Leplawy, M.L.; Latajka, Z.; Kozlowski, H., How the alpha-hydroxymethylserine residue stabilizes oligopeptide complexes with nickel(II) and copper(II) ions. J. Chem. Soc. Dalton Trans. 2000, 1033.
  64. Mlynarz, P.; Kowalik-Jankowska, T.; Stasiak, M.; Leplawy, M.T.; Kozlowski, H., Impact of alpha-hydroxymethylserine (HmS) residue on the binding ability of the histidyl residue in the HmS-His dipeptide towards Cu-II, Ni-II and Zn-II. J. Chem. Soc. Dalton Trans. 1999, 3673.
  65. Mlynarz, P.; Bal, W.; Kowalik-Jankowska, T.; Stasiak, M.; Leplawy, M.T.; Kozlowski, H., Introduction of alpha-hydroxymethylserine residues in a peptide sequence results in the strongest peptidic, albumin-like, copper(II) chelator known to date. J. Chem. Soc. Dalton Trans. 1999, 109.
  66. Szyrwiel, J.; Mlynarz, P.; Kozlowski, H.; Taddei, M., Chiral peptide nucleic acids: a new family of ligands for metal ions. J. Chem. Soc. Dalton Trans. 1998, 1263.