Publications Łukasz Berlicki

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Łukasz Berlicki

2017

Giberti, S.; Bertazzini, M.; Liboni, M.; Berlicki, Ł.; Kafarski, P.; Forlani, G., Phytotoxicity of aminobisphosphonates targeting both δ1-pyrroline-5-carboxylate reductase and glutamine synthetase Pest Manag. Sci. 2017, 72, 435.

Szefczyk, M.; Węglarz-Tomczak, E.; Fortuna, P.; Krzysztoń, A.; Rudzińska-Szostak, E.; Berlicki, Ł., Controlling the Helix Handedness of ααβ-Peptide Foldamers through Sequence Shifting Angew. Chem. Int. Ed. 2017, 56, 2087.

Macegoniuk, K.; Kowalczyk, R.; Rudzińska, A.; Psurski, M.; Wietrzyk, J.; Berlicki, Ł., Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling Bioorg. Med. Chem. Lett. 2017, 27, 1346.

Ntatsopoulos, V.; Vassiliou, S.; Macegoniuk, K.; Berlicki, Ł.; Mucha, A., Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophiles Eur. J. Med. Chem. 2017, 133, 107.

Wavhale, R. D.; Martis, E. A. F.; Ambre, P. K.; Wan, B.; Franzblau, S. G.; Iyer, K. R.; Raikuvar, K.; Macegoniuk, K.; Berlicki, Ł.; Nandan, S. R.; Coutinho, E. C., Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity Bioorg. Med. Chem. 2017, 25, 4835.

Macegoniuk, K.; Grela, E.; Biernat, M.; Psurski, M.; Gościniak, G.; Dziełak, A.; Mucha, A.; Wietrzyk, J.; Berlicki, Ł.; Grabowiecka, A., Aminophosphinates against Helicobacter pylori ureolysis—Biochemical and whole-cell inhibition characteristics PLoS One 2017, 1, 182437.

Rudzińska-Szostak, E.; Berlicki, Ł., Sequence engineering to control the helix handedness of peptide foldamers Chem. Eur. J. 2017, 23, 14980.

Magiera-Mularz, K.; Skalniak, L.; Zak, K. M.; Musielak, B.; Rudzinska-Szostak, E.; Berlicki, Ł.; Kocik, J.; Grudnik, P.; Sala, D. Zarganes-Tzitzikas, T.; Shaabani, S.; Dömling, A.; Dubin, G.; Holak, T. A., Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint Angew. Chem. Int. Ed. 2017, 56, 13732.


2016

Kosikowska, P.; Bochno, M.; Macegoniuk, K.; Forlani, G.; Kafarski, P.; Berlicki, Ł., Bisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase J. Enz. Inh. Med. Chem. 2016, 31, 931.

Wójcik, P.; Berlicki, Ł., Peptide-based inhibitors of protein–protein interactions. Bioorg. Med. Chem. Lett. 2016, 26, 707.

Węglarz-Tomczak, E.; Berlicki, Ł.; Pawełczak, M.; Nocek, B.; Joachimiak, A. Mucha, A., A structural insight into the P1-S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases. Eur. J. Med. Chem. 2016, 117, 187.

Macegoniuk, K.; Grela, E.; Palus, J.; Rudzińska-Szostak, E.; Grabowiecka, A.; Biernat, M.; Berlicki, Ł., 1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors. J. Med. Chem. 2016, 59, 8125.


2015

Macegoniuk, K.; Dziełak, A.; Mucha, A.; Berlicki, Ł., Bis(aminomethyl)phosphinic acid, a highly promising scaffold for the development of bacterial urease inhibitors. ACS Med. Chem. Lett. 2015, 6, 146.

Rudzińska-Szostak, E.; Górecki, Ł. Berlicki, Ł.; Ślepokura, K.; Mucha, A., Zwitterionic Phosphorylated Quinines as Chiral Solvating Agents for NMR Spectroscopy Chirality 2015, 27, 752.


2014

Bochno, M.; Berlicki, Ł., A three-component synthesis of aminomethylenebis-H-phosphinates. Tetrahedron Lett. 2014, 55, 219.

Cabrele, C.; Martinek, T. A.; Reiser, O.; Berlicki, Ł., Peptides containing beta-amino acid patterns—challenges and successes in medicinal chemistry J. Med. Chem. 2014, 57, 9718.

Vassiliou, S.; Węglarz-Tomczak, E.; Berlicki, Ł.; Pawełczak, M.; Nocek, B.; Mulligan, R.; Joachimiak, A.; Mucha, A., Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J. Med. Chem. 2014, 57, 8140.


2013

Węglarz-Tomczak, E.; Poręba, M.; Byzia, A.; Berlicki, Ł.; Nocek, B.; Mulligan, R.; Joachimiak, A.; Drąg, M.; Mucha, A., An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling. Biochimie 2013, 95, 419.

Benini, S.; Kosikowska, P.; Cianci, M.; Mazzei, L.; Vara, A. G.; Berlicki, Ł.; Ciurli, S., The crystal structure of Sporosarcina pasteurii urease in a complex with citrate provides new hints for inhibitor design. J. Biol. Inorg. Chem. 2013, 18, 391.

Drąg, M.; Wieczerzak, E.; Pawełczak, M.; Berlicki, Ł.; Grzonka, Z.; Kafarski, P., Toward very potent, non-covalent organophosphonate inhibitors of cathepsin C and related enzymes by 2-amino-1-hydroxy-alkanephosphonates dipeptides. Biochemie 2013, 95, 1640.

Forlani, G.; Berlicki, Ł.; Duò, M.; Dziędzioła, G.; Giberti, S.; Bertazzini, M.; Kafarski, P., Synthesis and Evaluation of Effective Inhibitors of Plant δ1-Pyrroline-5-carboxylate Reductase. J. Agric. Food Chem. 2013, 61, 6792.

Berlicki, Ł.; Kaske, M.; Gutierrez-Abad, R.; Bernhardt, G.; Illa, O.; Ortuño, R. M.; Cabrele, C.; Buschauer, A.; Reiser, O., Replacement of Thr32 and Gln34 in the C-terminal neuropeptide Y fragment 25-36 by cis-cyclobutane- and cis-cyclopentane β-amino acids shifts selectivity toward the Y4 receptor. J. Med. Chem. 2013, 56, 8422.


2012

Berlicki, Ł.; Bochno, M.; Grabowiecka, A.; Białas, A.; Kosikowska, P.; Kafarski, P., N-Substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases. Amino Acids 2012, 42, 1937.

Forlani, G.; Petrolino, D.; Fusetti M.; Romanini, L.; Nocek, B.; Joachimiak, A.; Berlicki, L.; Kafarski, P., Delta1-Pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo. Amino Acids 2012, 42, 2283.

Vassiliou, S.; Grabowiecka, A.; Kosikowska, P.; Berlicki, Ł., Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as a tool for screening of bacterial urease inhibitors ARKIVOC 2012, 2012, 33.

Górecki, Ł.; Berlicki, Ł.; Mucha, A.; Kafarski, P.; Ślepokura, K.; Rudzińska-Szostak, E., Phosphorylation as a Method of Tuning the Enantiodiscrimination Potency of Quinine – an NMR Study. Chirality 2012, 24, 318.

Berlicki, Ł.; Pilsl, L.; Wéber, E.; Mándity, I. M.; Cabrele, C.; Martinek, T. A.; Fülöp, F.; Reiser, O., Unique α,β- and α,α,β,β-peptide foldamers based on cis-β-aminocyclopentanecarboxylic acid. Angew. Chem. Int. Ed. Engl. 2012, 51, 2208.


2011

Kosikowska, P.; Berlicki, Ł., Urease inhibitors as potential drugs for gastric and urinary tract infections: A patent review. Expert Opin. Ther. Pat. 2011, 21, 945.

Mucha, A.; Kafarski, P.; Berlicki, Ł., Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry. J. Med. Chem. 2011, 54, 5955.


2010

Rudzińska, E.; Dziędzioła, G.; Berlicki, Ł.; Kafarski, P., Enantiodifferentiation of alpha–Hydroxyalkanephosphonic Acids in 31P NMR with Application of alpha–Cyclodextrin as Chiral Discriminating Agent. Chirality 2010, 22, 63.

Occhipinti, A.; Berlicki, Ł.; Giberti, S.; Dziędzioła, G.; Kafarski, P.; Forlani, G., Effectiveness and mode of action of phosphonate inhibitors of plant glutamine synthetase. Pest Manag. Sci. 2010, 66, 51.

Vassiliou, S.; Kosikowska, P.; Grabowiecka, A.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Computer-aided optimization of phosphinic inhibitors of bacterial ureases. J. Med. Chem. 2010, 53, 5597.


2009

Dąbrowska, E.; Burzyńska, A.; Mucha, A.; Matczak-Jon, E.; Sawka-Dobrowolska, W.; Berlicki, Ł.; Kafarski, P., Insight into the mechanism of three component condensation leading to aminomethylenebisphosphonates. J. Organomet. Chem. 2009, 694, 3806.

Rudzińska, E.; Berlicki, Ł.; Kafarski, P.; Lammerhofer, M.; Mucha, A., Cinchona alkaloids as privileged chiral solvating agents for enantiodiscrimination of N-protected aminoalkanephosphonates - a comparative NMR study. Tetrahedron Asymmetry 2009, 20, 2709.


2008

Berlicki, Ł., Inhibitors of glutamine synthetase and their potential application in medicine. Mini-reviews Med. Chem. 2008, 8, 869.

Forlani, G.; Occhipinti, A.; Berlicki, Ł.; Dziędzioła, G.; Wieczorek, A.; Kafarski, P. , Tailoring the Structure of Aminobisphosphonates to Target Plant P5C Reductase. J. Agric. Food Chem. 2008, 56, 3193.

Vassiliou, S.; Grabowiecka, A.; Kosikowska, P.; Yiotakis, A.; Kafarski, P.; Berlicki, Ł., Design, synthesis and evaluation of novel organophosphorus inhibitors of bacterial ureases. J. Med. Chem. 2008, 51, 5736.


2007

Rudzińska, E.; Poliwoda, A.; Berlicki, Ł.; Mucha, A.; Dżygiel, P.; Wieczorek, P.P.; Kafarski, P., Enantiodifferentiation of N-benzyloxycarbonylaminophosphonic and phosphinic acids and their esters using cyclodextrins by means of capillary electrophoresis. J. Chromat. A 2007, 1138, 284.

Berlicki, Ł.; Grembecka, J.; Dyguda-Kazimierowicz, E.; Kafarski, P.; Sokalski, W.A., From inhibitors of LAP to inhibitors of PAL. Lessons from Molecular Modeling and Experiment Interface. in Molecular Materials with Specific Interactions (Ed. W. A. Sokalski) 2007, 365.

Forlani, G.; Giberti, S.; Berlicki, Ł.; Petrollino, D.; Kafarski, P., Plant P5C reductase as a new target for aminomethylenebisphosphonates. J. Agric. Food Chem. 2007, 55, 4340.

Rudzińska, E.; Berlicki, Ł.; Mucha, A.; Kafarski, P., Analysis of pD Dependent Complexation of N-Benzyloxycarbonylaminophosphonic Acids by a-Cyclodextrin. Enantiodifferentation of Phosphonic Acid pKa V alues Chirality 2007, 19, 764.

Młynarz, P.; Rudzińska, E.; Berlicki, Ł.; Kafarski, P., Organophosphorus supramolecular chemistry. Part 2. Organophosphorus receptors Curr. Org. Chem. 2007, 11, 1593.

Rudzińska, E.; Berlicki, Ł.; Mucha, A.; Kafarski, P., Chiral discrimination of ethyl and phenyl N-benzyloxycarbonylaminophosphonates by cyclodextrins. Tetrahedron Asymmetry 2007, 18, 1579.

Berlicki, Ł.; Mucha, A.; Kafarski, P., A mild and convenient oxidation of H-phosphinic acids. Pol. J. Chem. 2007, 81, 1959.


2006

Berlicki, Ł.; Kafarski, P., Computer-aided analysis of the interactions of glutamine synthetase with its inhibitors. Bioorg. Med. Chem. 2006, 14, 4578.

Forlani, G.; Obojska, A.; Berlicki, Ł.; Kafarski, P., Phosphinothricin Analogues as Inhibitors of Plant Glutamine Synthetases. J. Agric. Food Chem. 2006, 54, 796.

Berlicki, Ł.; Rudzińska, E.; Młynarz, P.; Kafarski, P., Organophosphorus supramolecular chemistry. Part 1. Receptors for organophosphorus compounds. Curr. Org. Chem. 2006, 10, 2285.


2005

Berlicki, Ł.; Obojska, A.; Forlani, G.; Kafarski, P., Design, Synthesis, and Activity of Analogues of Phosphinothricin as Inhibitors of Glutamine Synthetase. J. Med. Chem. 2005, 48, 6340.

Berlicki, Ł.; Kafarski, P., Computer-Aided Analysis and Design of Phosphonic and Phosphinic Enzyme Inhibitors as Potential Drugs and Agrochemicals. Curr. Org. Chem. 2005, 9, 1829.

Lejczak, B.; Wojtasek, H.; Berlicki, Ł.; Forlani, G.; Obojska, A.; Drąg. M.; Gąsowska, B.; Grembecka, J.; Olechnowicz. D., Design, Synthesis and Evaluation of Environmentally Friendly Herbicides. Pol. J. Environ. Stud. 2005, 14, 64.


2004

Berlicki, Ł.; Rudzińska, E.; Mucha, A.; Kafarski, P., Cyclodextrins as NMR probes in the study of the enantiomeric compositions of N-benzyloxycarbonylamino-phosphonic and phosphinic acids. Tetrahedron-Asymmetry 2004, 15, 1597.

Obojska, A.; Berlicki, Ł.; Kafarski, P.; Lejczak, B.; Chicca, M.; Forlani, G., Herbicidal Pyridyl Derivatives of Aminomethylene-bisphosphonic Acid Inhibit Plant Glutamine Synthetase. J. Agric. Food. Chem. 2004, 52, 3337.

Kafarski, P.; Berlicki, Ł., Rational design of herbicides. Pestycydy-Pesticides 2004, 2004, 7.


2003

Berlicki, Ł.; Rudzińska, E.; Kafarski, P., Enantiodifferentiation of aminophosphonic and aminophosphinic acids with alpha- and beta-cyclodextrins. Tetrahedron-Asymmetry 2003, 14, 1535.

Kafarski, P.; Grembecka, J.; Mucha, A.; Pawełczak, M.; Drąg, M.; Berlicki, Ł.; Olechnowicz, D., Projektowanie Potencjalnych Leków i Pestycydów z Wykorzystaniem Wiedzy o Strukturze Przestrzennej Enzymów. Przem. Chem. 2003, 82, 1087.

Berlicki, Ł., Projektowanie związków biologicznie czynnych przy użyciu struktury krystalicznej enzymu. Na pograniczu chemii i biologii 2003, 9, 59.

Kafarski, P.; Drąg, M.; Berlicki, Ł.;Pawełczak, M., Synthesis and evaluation of phosphonopeptide Cathepsin C inhibitors. in Peptide Revolution: Genomics, Proteomics and Therapeutics, Eds. M. Chorev, T.K. Sawyer, Americam Peptide Society, Boston 2003, 310.


2002

Berlicki, Ł.; Kafarski, P., The use of molecular modelling for comparison of three possible modes of action of herbicidally active derivatives of aminomethylenebisphosphonic acid. Pest. Biochem. Physiol. 2002, 73, 94.