Publications Marcin Drąg

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Marcin Drąg


Teixeira PF, Kmiec B, Branca RM, Murcha MW, Byzia A, Ivanova A, Whelan J, Drag M, Lehtiö J, Glaser E., A multi-step peptidolytic cascade for amino acid recovery in chloroplasts. Nature Chemical Biology 2017, 13, 15.

Balogh B, Dahmen M, Stahl M, Poreba M, Gersch M, Drag M, Sieber SA , Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes Chemical Science 2017, 8, 1592.

Rut W, Zhang L, Kasperkiewicz P, Poreba M, Hilgenfeld R, Drag M, Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease Antiviral Research 2017, 139, 88.

Kasperkiewicz P, Poreba M, Groborz K, Drag M, Emerging challenges in the design of selective protease substrates, inhibitors and activity-based probes for indistinguishable proteases FEBS Journal 2017, 284, 1518.

Drag-Zalesinska M, Drag M, Poreba M, Borska S, Kulbacka J, Saczko J, Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45) Cancer Cell International 2017, 17, 7.

Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M, Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families Scientific Reports 2017, 7, 43135.

Lunde NN, Haugen MH, Bodin Larsen KB, Damgaard I, Pettersen SJ, Kasem R, Rut W, Drag M, Poreba M, Johansen HT, Solberg R, Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions Biochimie 2017, 139, 27.

Kasperkiewicz P, Altman Y, D'Angelo M, Salvesen GS, Drag M, A toolbox of fluorescent probes for parallel imaging reveals uneven location of serine proteases in neutrophils Journal of the American Chemical Society 2017, 139, 10115.


Gersch M, Stahl M, Poreba M, Dahmen M, Dziedzic A, Drag M, Sieber SA, Barrel-shaped ClpP proteases display attenuated cleavage specificity ACS Chemical Biology 2016, 11, 389.

Byzia, A.; Szeffler, A.; Kalinowski, L.; Drąg, M., Activity profiling of aminopeptidases in cell lysates using a fluorogenic substrate library Biochimie 2016, 122, 31.

Modak, J. K.; Rut, W.; Wijeyewickrema, L. C.; Pike, R. N.; Drąg, M.; Roujeinkova, A., Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase Biochimie 2016, 121, 60.

Rut, W.; Drąg, M., Human 20S proteasome activity towards fluorogenic peptides of various chain lengths Biol. Chem. 2016, 396, 921.

Drinkwater N, Sivaraman KK, Bamert RS, Rut W, Mohamed K, Vinh NB, Scammells PJ, Drag M, McGowan S, Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum Biochemical Journal 2016, 473, 3189.

Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M., Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes Cell Chemical Biology 2016, 23, 1023.

Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M, Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis. ACS infectious diseases 2016, 2, 807.


Hachmann, J.; Edgington-Mitchell, L. E.; Poreba, M.; Sanman, L. E.; Drag, M.; Bogyo, M.; Salvesen, G. S., Probes to Monitor Activity of the Paracaspase MALT1 Chem. Biol. 2015, 22, 139.

Lechtenberg, B. C.; Kasperkiewicz, P.; Robinson, H.; Drag, M.; Riedl, S. J., The Elastase-PK101 structure: Mechanism of an ultrasensitive activity-based probe revealed ACS Chem. Biol. 2015, 10, 945.

Rut, W.; Kasperkiewicz, P.; Byzia, A.; Poreba, M.; Groborz, K.; Drag, M., Recent advances and concepts in substrate specificity determination of proteases using tailored libraries of fluorogenic substrates with unnatural amino acids Biol. Chem. 2015, 396, 329.

Arya, T.; Reddi, R.; Kishor, C.; Ganji, R.J.; Bhukya, S.; Gumpena, R.; McGowan, S.; Drag, M.; Addlagatta, A., Identification of the molecular basis of inhibitor selectivity between the human and Streptococcal Type I methionine aminopeptidases. J. Med. Chem. 2015, 58, 2350.

Bekes, M.; Rut, W.; Kasperkiewicz, P. Mulder, M. P.; Ovaa, H.; Drag, M.; Lima, C. D.; Huang, T. T., SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme. Biochem. J. 2015, 468, 215.

Drag-Zalesinska M, Wysocka T, Borska S, Drag M, Poreba M, Choromanska A, Kulbacka J, Saczko J., The new esters derivatives of betulin and betulinic acid in epidermoid squamous carcinoma treatment - In vitro studies. Biomedicine & Pharmacotherapy 2015, 72, 91.

Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M., Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4. PLoS One 2015, 10, 1.

Rajkovic, J.; Poreba, M.; Caglic, D.; Vidmar, R.; Wilk, A.; Borowik, A.; Salvesen, G. S.; Turk, V.; Drag, M.; Turk, B., Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi J. Biol. Chem. 2015, 290, 28231.

Galiullina RA, Kasperkiewicz P, Chichkova NV, Szalek A, Serebryakova MV, Poreba M, Drag M, Vartapetian AB, Substrate Specificity and Possible Heterologous Targets of Phytaspase, a Plant Cell Death Protease. Journal of Biological Chemistry 2015, 290, 24806.

Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M, Small Molecule Active Site Directed Tools for Studying Human Caspases Chemical Reviews 2015, 115, 12546.

van der Linden, W. A.; Segal, E.; Child, M. A.; Byzia, A. Drąg, M.; Bogyo, M., Design and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase Chem. Biol. 2015, 22, 995.


Poręba, M.; Mihelic, M.; Krai, P.; Rajkovic, J.; Krężel, A.; Pawełczak, M.; Klemba, M.; Turk, D.; Turk, B.; Latajka, R.; Drąg, M., Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C. Amino Acids 2014, 46, 931.

Kasperkiewicz, P.; Poreba, M.; Snipas, S. J.; Parker, H.; Winterbourn, C. C.; Salvesen, G. S.; Drag, M., Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 2518.

Byzia, A; Haeggström, J.Z.; Salvesen, G.S.; Drąg, M., A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids. Amino Acids 2014, 46, 1313.

Poręba, M.; Szalek, A.; Kasperkiewicz, P.; Drąg, M., Positional Scanning Substrate Combinatorial Library (PS-SCL) Approach to Define Caspase Substrate Specificity. Methods Mol. Biol. 2014, 1133, 41.

Pustelny, K.; Zdzalik, M.; Stach, N.; Stec-Niemczyk, J.; Cichon, P.; Czarna, A.; Popowicz, G.; Mak, P.; Drag, M.; Salvesen, G. S.; Wladyka, B.; Potempa, J.; Dubin, A.; Dubin, G., Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation. J. Biol. Chem. 2014, 298, 15544.

Gras, S.; Byzia, A.; Gilbert, F.B.; McGowan, S.; Drąg, M.; Silvestre, A.; Niepceron, A.; Lecaille, F.; Lalmanach, G.; Fabien Brossier, F., Aminopeptidase N1 (Et-ApN1), a M1 metalloprotease of the apicomplexan parasite Eimeria tenella participates in parasite development Eukaryotic Cell 2014, 13, 884.

Poreba, M.; Kasperkiewicz, P.; Snipas, S. J.; Fasci, D.; Salvesen, G. S.; Drąg, M., Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates Cell Death & Differentiation 2014, 21, 1482.

Mistry, S.N.; Drinkwater, N.; Ruggeri, C.; Kannan Sivaraman, K.; Loganathan, S.; Fletcher, S.; Drag, M.; Paiardini, A.; Avery, V.M.; Scammells, P.J.; McGowan, S., A Two-pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic acid-based Inhibitors. J. Med. Chem. 2014, 57, 9168.


Węglarz-Tomczak, E.; Poręba, M.; Byzia, A.; Berlicki, Ł.; Nocek, B.; Mulligan, R.; Joachimiak, A.; Drąg, M.; Mucha, A., An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling. Biochimie 2013, 95, 419.

Carroll, R.K.; Veillard, F.; Gagne, D.T.; Lindenmuth, J.M.; Poreba, M.; Drag, M.; Potempa, J.; Shaw, L.N., The Staphylococcus aureus leucine aminopeptidase LAP is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine. Biol. Chem. 2013, 394, 791.

Drąg, M. , Chapter 478 – OTU1 Peptidase Handbook of Proteolytic Enzymes 2013, 2, 2121.

Drąg, M. , Chapter 532 – SENP8 Peptidase Handbook of Proteolytic Enzymes 2013, 2, 2379.

Drąg, M.; Wieczerzak, E.; Pawełczak, M.; Berlicki, Ł.; Grzonka, Z.; Kafarski, P., Toward very potent, non-covalent organophosphonate inhibitors of cathepsin C and related enzymes by 2-amino-1-hydroxy-alkanephosphonates dipeptides. Biochemie 2013, 95, 1640.

Zeiler, E.; List, A.; Alte, F.; Gersch, M.; Wachtel, R.; Poręba, M.; Drąg, M.; Groll, M.; Sieber, S.A., Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 11302.

Kannan Sivaraman,K.; Paiardini, A.; Sieńczyk, M.; Ruggeri, C.; Oellig, C. A.; Dalton, J. P.; Scammells, P. J.; Drag, M.; McGowan , S., Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J. Med. Chem. 2013, 56, 5213.

Poręba, M.; Stróżyk, A.; Salvesen, G.S.; Drag, M. , Caspase Substrates and Inhibitors. Cold Spring Harb. Perspect. Biol. 2013, 5, 1.


Poreba, M.; McGowan, S.; Skinner-Adams, T. S.; Trenholme, K. R.; Gardiner, D. L.; Whisstock, J. C.; To, J.; Salvesen, G. S.; Dalton, J. P.; Drąg, M., Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium Falciparum. PLoS One 2012, 7, 31938.

Gajda, A. D.; Pawleczak, M.; Drąg, M., Substrate specificity screening of oat (Avena sativa) seeds aminopeptidase demonstrate unusually broad tolerance in S1 pocket. Plant Physiol. Biochem. 2012, 54, 6.

Poręba, M.; Gajda, A.; Picha, J.; Jiracek, J.; Marschner, A.; Klein, C.; Salvesen, G. S.; Drąg, M., S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors. Biochimie 2012, 94, 704.

Bekes, M.; Drąg, M., Trojan horse strategies used by pathogens to influence the SUMO system of host eukaryotic cells. J. Innate Immun. 2012, 4, 159.

Sivaraman, K.K.; Oellig, C.A.; Huynh, K.; Atkinson, S.C.; Poreba, M.; Perugini, M.A.; Trenholme, K.R.; Gardiner, D.L.; Salvesen, G.; Drag, M.; Dalton, J.P.; Whisstock, J.C.; McGowan, S., X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP. J. Mol. Biol. 2012, 422, 495.

Veillard, F.; Potempa, B.; Poreba, M.; Drag, M.; Potempa, J., Gingipain aminopeptidase activities in Porphyromonas gingivalis. Biol. Chem. 2012, 393, 1471.

Aleshin, A.E.; Marcin Drag, M.; Gombosuren, N.; Wei, G.; Mikolajczyk, J.; Arnold C. Satterthwait, A.C.; Strongin, A. Y.; Liddington, R.C.; Salvesen, G.S., Activity, Specificity and Probe Design for the Smallpox Virus Protease K7L. J. Biol. Chem. 2012, 287, 47.

Kasperkiewicz, P.; Gajda, A. D.; Drąg, M., Current and prospective applications of non-proteinogenic amino acids in profiling of proteases substrate specificity Biol. Chem. 2012, 393, 843.

Hachmann, J.; Snipas, S. J.; van Raam, B. J.; Cancino, E. M.; Houlihan, E. J.; Poreba, M.; Kasperkiewicz, P.; Drag, M.; Salvesen, G. S., Mechanism and specificity of the human paracaspase MALT1 Biochem. J. 2012, 443, 287.


Ponder, E. L.; Albrow, V. E.; Leader, B. A.; Bekes, M.; Mikolajczyk, J.; Pecar Fonovic, U.; Shen, A.; Drąg, M.; Xiao, J.; Deu, E.; Campbell, A. J.; Powers, J. C.; Salvesen, G. S.; Bogyo, M. , Functional Characterization of a SUMO Deconjugating Protease of Plasmodium falciparum Using Newly Identified Small Molecule Inhibitors. Chemistry & Biology 2011, 18, 711.

Volle, J.-N.; Filippini, D.; Midrier, C.; Sobecki, M.; Drąg, M.; Virieux, D.; Pirat, J.-L., Revisited Synthesis of Aryl-H-phosphinates. Synthesis 2011, 2011, 2490.

Zervoudi, E.; Papakyriakou, A.; Georgiadou, D.; Evnouchidou, I.; Gajda, A.; Poręba, M.; Salvesen, G. S.; Drąg, M.; Hattori, A.; Swevers, L.; Vourloumis, D.; Stratikos, E., Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. Biochem J. 2011, 435, 411.

Boucher, D.; Blais, V.; Drąg, M.; Denault, J.-B., Molecular determinants involved in activation of caspase 7. Biosci Rep. 2011, 31, 283.

Pop, C.; Oberst, A.; Drąg, M.; Van Raam, B. J.; Riedl, S. J.; Green, D. R.; Salvesen, G. S. , FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J. 2011, 433, 447.


Skinner-Adams, T. S.; Stack, C. M.; Trenholme, K. R.; Brown, C. L.; Grembecka, J.; Lowther, J.; Mucha, A.; Drag, M.; Kafarski, P.; McGowan, S.; Whisstock, J. C.; Gardiner, D. L.; Dalton, J. P., Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials. Trends Biochem. Sci. 2010, 35, 53.

Mucha, A.; Drą…g, M.; Dalton, J. P.; Kafarski, P., Metallo-aminopeptidase inhibitors. Biochimie 2010, 92, 1509.

Drąg, M.; Bogyo, M.; Ellman, J. A.; Salvesen, G. S. , Aminopeptidase fingerprints. An integrated approach for identification of good substrates and optimal inhibitors. J. Biol. Chem. 2010, 285, 3310.

Grzywa, R.; Oleksyszyn, J.; Salvesen, G. S.; Drąg, M. , Identification of very potent inhibitor of human aminopeptidase N (CD13). Bioorg. Med. Chem. Lett. 2010, 20, 2497.

Shu, C.-W.; Drąg, M.; Bekes, M.; Zhai, D.; Salvesen, G. S.; Reed, J. C., Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy 2010, 6, 936.

Wachmann, K.; Pop, C.; van Raam, B. J.; Drąg, M.; Mace, P. D.; Snipas, S. J.; Zmasek, C.; Schwarzenbacher, R.; Salvesen, G. S.; Riedl, S. J., Activation and specificity of human caspase-10. Biochemistry 2010, 49, 8307.

Kolli, N.; Mikolajczyk, J.; Drąg, M.; Mukhopadhyay, D.; Moffatt, N.; Dasso, M.; Salvesen, G. S.; Wilkinson, K. D., Distribution and paralogue specificity of mammalian deSUMOylating enzymes. Biochem. J. 2010, 430, 335.

Drąg, M.; Salvesen, G. S., Emerging principles in protease-based drug discovery. Nature Reviews Drug Discovery 2010, 9, 690.

Poręba, M.; Drąg, M., Current strategies for probing substrate specificity of proteases. Curr. Med. Chem. 2010, 17, 3968.


Podstawka, E.; Kudelski, A.; Drąg, M.; Oleksyszyn, J.; Proniewicz, L. M., Adsorbed states of substituted α-aminophosphinic acids on silver electrode surface. Comparison with colloidal silver substrate. J. Raman Spect. 2009, 11, 1578.

Podstawka, E.; Drąg, M.; Oleksyszyn, J., Raman and surface-enhanced Raman studies of α-aminophosphinic inhibitors of metalloenzymes. J. Raman Spect. 2009, 11, 1564.

Surowiak, P.; Drąg, M.; Materna, V.; Dietel, M.; Lage, H., Betulinic acid reveal stronger cytotoxic activity toward normal melanocyte cell line (NHEM-neo) than drug-resistant and drug-sensitive melanoma cell lines (MeWo). Mol. Med. Rep. 2009, 2, 543.

Szczuraszek, K.; Materna, V.; Halon, A.; Mazur, G.; Wróbel, T.; Kuliczkowski, K.; Maciejczyk, A.; Zabel, M.; Drąg, M.; Dietel, M.; Lage, H.; Surowiak, P., Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin Oncol. Rep. 2009, 22, 1315.

Walters, J.; Pop, C.; Scott, F. L.; Drąg, M.; Swartz, P.; Mattos, C.; Salvesen, G. S.; Clark, C. A., A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem. J. 2009, 424, 335.

Drąg-Zalesińska, M.; Kulbacka, J.; Saczko, J.; Wysocka, T.; Zabel, M.; Surowiak, P.; Drąg, M., Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. Bioorg. Med. Chem. Lett. 2009, 19, 4814.

Drąg, M.; Surowiak, P.; Drąg-Zalesinska, M.; Dietel, M.; Lage, H.; Oleksyszyn, J., Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules 2009, 14, 1639.


Cunningham, E.; Drą…g, M.; Kafarski, P.; Bell, A., Chemical Target Validation Studies of Aminopeptidase in Malaria Parasites Using alpha-Aminoalkylphosphonate and Phosphonopeptide Inhibitors Antimicrob. Agents Chemother. 2008, 52, 3221.

Drąg, M.; Mikołajczyk, J.; Menon, K.; Huang, Z.; Salvesen, G. S., Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates reveals unexpected specificity of two newly characterized members of the family. Biochem. J. 2008, 409, 461.

Eckelman, B. P.; Drąg, M.; Snipas, S. J.; Salvesen, G. S., The Mechanism of Peptide Binding Specificity of IAP BIR domains. Cell Death Differ. 2008, 15, 920.

Snipas, S. J.; Drąg, M.; Stennicke, H. R.; Salvesen, G. S., Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC. Cell Death Differ. 2008, 15, 938.

Surowiak, P.; Pawełczyk, K.; Maciejczyk, A.; Pudełko, M.; Kołodziej, J.; Zabel, M.; Murawa, D.; Drąg, M.; Gansukh, T.; Dietel, M.; Lage, H. , Positive Correlation between Cyclooxygenase 2 and the Expression of ABC-transporters in Non-small Cell Lung Cancer. Anticancer Res. 2008, 28, 2867.

Drąg, M.; Salvesen, G. S., DeSUMOylating enzymes-SENPs (Review). IUBMB Life 2008, 60, 734.

Drąg, M.; Mikolajczyk, J.; Bekes, M.; Reyes-Turcu, F.; Ellman, J. A.; Wilkinson, K. D.; Salvesen, G. S., Positional-scanning fluorogenic substrate libraries reveal unexpected specificity determinants of deubiquitinating enzymes (DUBs). Biochem. J. 2008, 415, 367.


Drąg, M.; Grzywa, R.; Oleksyszyn, J. , Novel hydroxamic acid related phosphinates: inhibitor of neutral aminopeptidase N (APN). Bioorg. Med. Chem. Lett. 2007, 17, 1516.

Mikolajczyk, J.; Drąg, M.; Bekes, M.; Cao, J. T.; Ronai, Z.; Salvesen, G. S. , SUMO-specific proteases: Profiling the specificities and activities of human SENPs. J. Biol. Chem. 2007, 282, 26217.

Denault, J.-B.; Drąg, M.; Salvesen, G. S.; Alves, J.; Heidt, A.; Deveraux, Q.; Harris, J. L., Small molecules not direct activators of caspases. Nature-Chemical Biology 2007, 9, 520.


Drąg, M.; Długosz, K.; Oleksyszyn J., A facile synthesis of bis-alpha-aminoalkyl- phosphinates. Synthetic Commun. 2006, 36, 2787.

Surowiak, P.; Drąg, M.; Materna, V.; Suchocki, S.; Grzywa, R.; Spaczynski, M.; Dietel, M.; Oleksyszyn, J.; Zabel, M.; Lage H., Expression of aminopeptidase N/CD13 in human ovarian cancers. Int. J. Gynecol. Cancer 2006, 16, 1783.


Lejczak, B.; Wojtasek, H.; Berlicki, Ł.; Forlani, G.; Obojska, A.; Drąg. M.; Gąsowska, B.; Grembecka, J.; Olechnowicz. D., Design, Synthesis and Evaluation of Environmentally Friendly Herbicides. Pol. J. Environ. Stud. 2005, 14, 64.

Gał‚ezowska, J.; Sobek, S.; Drag, M.; Mucha, A.; Kafarski, P.; Kozł‚owski, H. , Specific interactions of divalent metal ions with phosphonic analogues of dipeptide inhibitors of proteases. Pol. J. Chem. 2005, 79, 603.

Drąg, M.; Grembecka, J.; Pawełczak, M.; Kafarski, P. , alpha-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine - and neutral aminopeptidases. Eur. J. Med. Chem. 2005, 40, 764.

Podstawka, E.; Borszowska, R.; Grabowska, M.; Drag, M.; Kafarski, P.; Proniewicz, L.M., Investigation of molecular structures and adsorption mechanisms of phosphonodipeptides by surface-enhanced Raman, Raman, and infrared spectroscopies. Surf. Sci. 2005, 599, 207.

Drąg, M.; Oleksyszyn, J. , Synthesis of a1-(Cbz-aminoalkyl)-a2-(hydroxyalkyl)phosphinic esters. Tetrahedron Lett. 2005, 46, 3359.

Drąg, M.; Sieńczyk, M.; Marcinkowska, A.; Drąg-Zalesińska, M.; Wysocka, T.; Oleksyszyn, J., Alpha-Aminophosphonates Induce Apoptosis in Human Tumor Cell Lines Pol. J. Chem 2005, 79, 593.


Gumienna-Kontecka, E.; Galezowska, J.; Drag, M.; Latajka, R.; Kafarski, P.; Kozlowski, H., Coordination abilities of substituted beta-aminophosphonates towards Cu2+ and Zn2+ ions. Inorganica Chimica Acta 2004, 357, 1632.

Drag, M.; Jezierski, A.; Kafarski, P., First example of the chemical, oxidative cleavage of the C-P bond in aminophosphonate chemistry. The oxidation of 1-amino-1-amino-1-(3,4-dihydroxyphenyl)methylphosphonic acid by NaIO4. Chem. Comm. 2004, 9, 1132.


Kafarski, P.; Grembecka, J.; Mucha, A.; Pawełczak, M.; Drąg, M.; Berlicki, Ł.; Olechnowicz, D., Projektowanie Potencjalnych Leków i Pestycydów z Wykorzystaniem Wiedzy o Strukturze Przestrzennej Enzymów. Przem. Chem. 2003, 82, 1087.

Drag, M.; Pawelczak, M.; Kafarski, P., Stereoselective synthesis of 1-aminoalkanephosphonic acids with two chiral centers and their activity towards leucine aminopeptidase. Chirality 2003, 15, 104.

Drag, M.; Latajka, R.; Gumienna-Kontecka, E.; Kozlowski, H.; Kafarski, P. , Stereoselective synthesis, solution structure and metal complexes of (1S,2S)-2-amino-1-hydroxyalkylphosphonic acids. Tetrahedron-Asymmetry 2003, 14, 1837.

Kafarski, P.; Drąg, M.; Berlicki, Ł.;Pawełczak, M., Synthesis and evaluation of phosphonopeptide Cathepsin C inhibitors. in Peptide Revolution: Genomics, Proteomics and Therapeutics, Eds. M. Chorev, T.K. Sawyer, Americam Peptide Society, Boston 2003, 310.


Drag, M.; Grembecka, J.; Kafarski, P., The computer-aided design, synthesis, and activity prediction of new leucine aminopeptidase inhibitors. Phosphorus, Sulfur 2002, 177, 1591.

Drag, M.; Latajka, R.; Gancarz, R.; Kafarski, P.; Pirat, J.L.; Cristau, H.J. , Regio- and stereoselective synthesis, solution conformations of 2-amino-1-hydroxy-2-arylethylphosphonic esters and acids. Phosphrus, Sulfur, and Silicon, and Rel. Elem. 2002, 177, 2191.

Latajka, R.; Drag, M.; Gancarz, R.; Kafarski, P. , Solution conformations of 2-amino-1-hydroxy-2-aryl ethylphosphonic acids and their diethyl esters. J. Mol. Struct. 2002, 605, 79.

Gąsowska, B.; Wojtasek, H.; Hurek, J.; Drąg, M.; Nowak, K.; Kafarski, P., Redox reaction between amino-(3,4-dihydroxyphenyl)methylphosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase Eur. J. Biochem. 2002, 269, 4098.

Drąg, M.; Kafarski, P.; Pirat, J.-L.; Cristau, H.-J., Unexpected opening of diethyl (+/-) - (S,S) - 1,2 - epoxy - 2 – phenylpentyl- phosphonate by NH3(aqu.): An easy entry to ethyl 1 - formyl - 1 – phenylbuthyl- phosphonate Phosphorus, Sulfur and Silicon 2002, 177, 1153.


Cristau, H.-J.; Pirat, J.-L.; Drąg, M.; Kafarski, P., Regio- and stereoselective synthesis of 2-amino-1-hydroxy-2-aryl ethylphosphonic esters Tetrahedron Lett. 2000, 41, 9781.