Publications Rafal Latajka

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Rafał Latajka


Hałdys K., Goldeman W., Jewgiński M., Wolińska E., Anger-Góra N., Rossowska J., Latajka R., Halogenated aromatic thiosemicarbazones as potent inhibitors of tyrosinase and melanogenesis Bioorganic Chemistry 2020, 94, 103419.


Katarzyna Hałdys, Rafał Latajka, Thiosemicarbazones with tyrosinase inhibitory activity MedChemComm 2019, 10, 378.

Schröder D.C., Kracker O., Fröhr T., Góra J., Jewginski M., Nieß A., Antes I., Latajka R., Marion A., Sewald N., 1,4-Disubstituted 1H-1,2,3-Triazole Containing Peptidotriazolamers: A New Class of Peptidomimetics With Interesting Foldamer Properties Frontiers in Chemistry 2019, 7, 1.

Wolinska, E.; Hałdys, K.; Góra, J.; Olszewski, T.K.; Boduszek, B.; Latajka, R., Phosphonic and phosphinic acid derivatives as novel tyrosinaseinhibitors: Kinetic studies and molecular docking. Chem. Biodiversity 2019, 1.

Urbańczyk M., Jewgiński M, Krzciuk-Gula J., Góra J., Latajka R., Sewald N., Synthesis and conformational preferences of short analogues of antifreeze glycopeptides (AFGP) Beilstein J. Org. Chem. 2019, 15, 1581.


Hałdys, K.; Goldeman, W.; Jewgiński, M.; Wolińska, E.; Anger, N.; Rossowska, J.; Latajka, R.;, Inhibitory properties of aromatic thiosemicarbazones on mushroom tyrosinase: Synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis inhibition. Bioorg. Chem. 2018, 81, 577.

Malik-Gajewska, M.; Trynda, J.; Zierkiewicz, W.; Helios, K.; Latajka, R.; Wietrzyk, J.; Michalska, D., Picoplatin-based complexes with the bioactive orotate and 5-fluoroorotate ligands: Synthesis, DFT calculations, structure, spectroscopic characterization and in vitro cytotoxicity. J. Mol. Struct. 2018, 1171, 155.

Kracker, O.; Góra, J.; Krzciuk-Gula, J.; Marion, A.; Neumann, B.; Stammler, H-G.; Niess, A.; Antes, I.; Latajka, R.; Sewald, N., 1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics. Chem. Eur. J. 2018, 24, 953.

Marion, A.; Gora, J.; Kracker, O.; Frohr, T.; Latajka, R.; Sewald, N.; Antes, I., Amber-Compatible Parametrization Procedure for Peptide-like Compounds: Application to 1,4- and 1,5-Substituted Triazole-Based Peptidomimetics. J. Chem. Inf. Model. 2018, 58, 90.


Lenartowicz, P.; Makowski, M.; Oszywa, B.; Haremza, K.; Latajka, R.; Pawełczak, M.; Kafarski, P., Addition of thiols to the double bond of dipeptide C -terminal dehydroalanine as a source of new inhibitors of cathepsin C Biochimie 2017, 139, 46.

Urbańczyk, M.; Góra, J.; Latajka, R.; Sewald, N., Antifreeze glycopeptides: from structure and activity studies to current approaches in chemical synthesis. Amino Acids 2017, 49, 209.


Lamch, Ł.; Tylus, W.; Jewgiński, M.; Latajka, R.; Wilk, K.A., Location of Varying Hydrophobicity Zinc(II) Phthalocyanine-Type Photosensitizers in Methoxy Poly(ethylene oxide) and Poly(L‑lactide) Block Copolymer Micelles Using 1H NMR and XPS Techniques. J. Phys. Chem. B 2016, 120, 12768.


Góra, J.; Latajka, R., Involvement of Cysteine Proteases in Cancer. Curr. Med. Chem. 2015, 22, 944.


Buczek A, Makowski M, Jewginski M, Latajka R, Kupka T, Broda M, Toward Engineering Efficient Peptidomimetics. Screening Conformational Landscape of Two Modified Dehydroaminoacids Biopolymers 2014, 101, 28.

Poręba, M.; Mihelic, M.; Krai, P.; Rajkovic, J.; Krężel, A.; Pawełczak, M.; Klemba, M.; Turk, D.; Turk, B.; Latajka, R.; Drąg, M., Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C. Amino Acids 2014, 46, 931.

Jewgiński, M; Krzciuk-Gula, J.; Makowski, M.; Latajka, R. Kafarski P., Conformation of dehydropentapeptides containing four achiral amino acid residues – controlling the role of L-valine Beilstein J. Org. Chem. 2014, 10, 660.

Dudka, I.; Kossowska, B.; Senhadri, H.; Latajka, R.; Hajek, J.; Andrzejak, R.; Antonowicz-Juchniewicz, J.; Gancarz, R., Metabonomic analysis of serum of workers occupationally exposed to arsenic, cadmium and lead for biomarker research: A preliminary study. Environment International 2014, 68, 71.


Jewgiński, M.; Latajka, R.; Krężel, A.; Haremza, K.; Makowski, M.; Kafarski, P., Influence of solvents on conformation of dehydropeptides J. Mol. Struct. 2013, 1035, 129.


Pluskota-Karwatka, D. ; Pawłowicz, A. J.; Bruszyńska, M.; Greszkiewicz, A.; Latajka, R.; Kronberg, L., Identification of Adducts Formed in the Reactions of Malonaldehyde – glyoxal and Malonaldehyde – methylglyoxal with Adenosine and Calf Thymus DNA Chemistry & Biodiversity 2010, 7, 959.

Lisowski M., Jaremko Ł., Jaremko M., Mazur A., Latajka R., Makowski M. , Effect of the dPhe residue configuration on a didehydropeptides conformation: a combined CD and NMR study Biopolymers 2010, 93, 1055.


Latajka, R.; Krężel, A.; Mucha, A.; Jewgiński, M.; Kafarski, P., Conformational investigations of bis(alpha-aminoalkyl)phosphinic acids and studies of the stability of their complexes with Cu(II). J. Mol. Str. 2008, 877, 64.

Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Klimek-Ochab, M.; Latajka, R.; Kafarski, P.; Lejczak, B., Chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethylphosphonate as a valuable product of microbial biotransformation of diethyl 2-oxo-2-phenylethylphosphonate J. Mol. Cat. B 2008, 52, 74.

Lisowski, M.; Latajka, R.; Picur, B.; Lis, T.; Bryndal, I.; Rospenk, M.; Makowski, M.; Kafarski, P., Combined effect of the dehydro-Phe or dehydro-Ala residue and the p-nitroanilide group on a dehydropeptides conformation Biopolymers 2008, 89, 220.

Latajka, R.; Jewgiński, M.; Makowski, M.; Krężel, A.; Paluch, S., Conformational studies of hexapeptides containing two dehydroamino acid residues in positon 2 and 5 in peptide chain Biopolymers 2008, 89, 691.

Latajka, R.; Jewginski, M.; Makowski, M., Pawełczak, M.; Huber, T.; Sewald, N.; Kafarski, P., Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C J. Pept. Sci. 2008, 14, 1084.

Latajka, R.; Jewgiński, M.; Makowski, M.; Krężel, A.;, Conformational studies of hexapeptides containing two dehydroamino acid residues in positon 3 and 5 in peptide chain J. Mol. Struct. 2008, 1.


Młynarz, P.; Jewgiński, M.; Sliwinska, S.; Latajka, R.; Schroeder, G.; Kafarski, P., Twin phosphorous atoms of tetraethyl 2-methyl-piperyd-1-ylmethylenebisphosphonates Heteroatom Chem. 2007, 18, 774.


Latajka, R.; Makowski, M.; Jewginski, M.; Pawelczak, M.; Koroniak, H.; Kafarski, P., Peptide p-nitrophenylanilides containing (E)-dehydrophenylalanine - synthesis, structural studies and evaluation of their activity towards cathepsin C. New J. Chem. 2006, 30, 1009.


Frackowiak, B.; Olejniczak, T.; Latajka, R.; Bialonska, A.; Ciunik, Z.; Lochynski, S. , Stereochemistry of terpene derivatives. Part 4: Fragrant terpenoid derivatives with an unsaturated gem-dimethylbicyclo[3.1.0]hexane system. Tetrahedron: Asymmetry 2005, 16, 3352.


Gumienna-Kontecka, E.; Galezowska, J.; Drag, M.; Latajka, R.; Kafarski, P.; Kozlowski, H., Coordination abilities of substituted beta-aminophosphonates towards Cu2+ and Zn2+ ions. Inorganica Chimica Acta 2004, 357, 1632.

Zon, J.; Szefczyk, B.; Sawka-Dobrowolska, W.; Gancarz, R.; Kucharska-Zon, M.; Latajka, R.; Amrhein, N.; Miziak, P.; Szczepanik, W., Experimental and ab initio calculated structures of 2-aminoindane-2-phosphonic acid, a potent inhibitor of phenylalanine ammonia-lyase, and theoretical studies of its binding to the model enzyme structure. New J. Chem. 2004, 28, 1048.


Drag, M.; Latajka, R.; Gumienna-Kontecka, E.; Kozlowski, H.; Kafarski, P. , Stereoselective synthesis, solution structure and metal complexes of (1S,2S)-2-amino-1-hydroxyalkylphosphonic acids. Tetrahedron-Asymmetry 2003, 14, 1837.

Krężel, A.; Latajka, R.; Bujacz, G.D.; Bal, W. , Coordination properties of tris(2-carboxyethyl)phosphine, a newly introduced thiol reductant, and its oxide. Inorg. Chem. 2003, 42, 1994.

Latajka, R.; Jewginski, M.; Pawelczak, M.; Makowski, M.; Kafarski, P., Conformational preferences and biological activity of short peptides containing (e)dehydrophenylalanine. Biopolymers 2003, 73, 301.


Kilyen, M.; Lakatos, A.; Latajka, R.; Labadi, I.; Salifoglou, A.; Raptopoulou, C.P.; Kozlowski, H.; Kiss, T., Al(III)-binding properties of iminodiacetic acid, nitrilotriacetic acid and their mixed carboxylic-phosphonic derivatives. J. Chem. Soc. Dalton Trans. 2002, 3578.

Drag, M.; Latajka, R.; Gancarz, R.; Kafarski, P.; Pirat, J.L.; Cristau, H.J. , Regio- and stereoselective synthesis, solution conformations of 2-amino-1-hydroxy-2-arylethylphosphonic esters and acids. Phosphrus, Sulfur, and Silicon, and Rel. Elem. 2002, 177, 2191.

Latajka, R.; Gancarz, R.; Kafarski, P. , Slow inversion of stereoisomers of 4-amino-1-benzylpiperid-4-yl phosphonic acids and their esters. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2002, 177, 1575.

Latajka, R.; Drag, M.; Gancarz, R.; Kafarski, P. , Solution conformations of 2-amino-1-hydroxy-2-aryl ethylphosphonic acids and their diethyl esters. J. Mol. Struct. 2002, 605, 79.


Makowski, M.; Pawelczak, M.; Latajka, R.; Nowak, K.; Kafarski, P. , Synthesis of tetrapeptide p-nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activity. J. Pept. Sci. 2001, 7, 141.

Boduszek, B.; Latajka, R.; Walkowiak, U. , Acid-catalyzed cleavage of some chromone, coumarin and pyrone derivatives of aminomethylphosphonic acid. Products and kinetics of the reaction. Pol. J. Chem. 2001, 75, 63.


Boduszek, B.; Latajka, R.; Lesniak, W. , Acid-catalyzed cleavage of 2-pyridyl and 4-pyridyl derivatives of aminomethylphosphonic acid. Kinetic and chemical arguments for a mechanism with A-S(E)2 character. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2000, 165, 53.

Gancarz, R.; Latajka, R.; Halama, A.; Kafarski, P. , Slow inversion of stereoisomers of cyclic GABA analogues. Magn. Res. Chem. 2000, 38, 867.

Boduszek, B.; Halama, A.; Latajka, R. , A simple one-step synthesis of monoesters of aminophosphonic acids. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2000, 158, 141.

Gancarz, R.; Latajka, R.; Maluszek, B.; Żymańczyk-Duda, E.; Kafarski, P. , Hydrogen bonding in diethyl 2-hydroxypropylphosphonate - an example of equilibrium between intramolecular and intermolecular bonding. Magn. Res. Chem. 2000, 38, 197.


Bal, W.; Dyba, M.; Kasprzykowski, F.; Kozłowski, H.; Latajka, R.; Lankiewicz, L.; Mackiewicz, Z.; Pettit, L.D., How non-bonding amino acid side-chains may enormously increase the stability of a Cu(II)-peptide complex. Inorg. Chim. Acta 1998, 283, 1.