Rafał Kowalczyk

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Status: married

Hobby: cinema, book reading (sci-fi, detective novels).

Phone: (48-71) 320 38 29 / 33 58, Fax: (48-71) 320 24 27


Department of Bioorganic Chemistry,

Faculty of Chemistry,

Wroclaw University of Science and Technology,

Wybrzeże Wyspianskiego 27,

50-370 Wroclaw, Poland

e-mail: rafal.kowalczyk@pwr.edu.pl


  • 2002 - M.Sc. (Faculty of Chemistry, Wrocław University of Technology)
  • 2006 - Ph.D. (Institute of Organic Chemistry, Biochemistry and Biotechnology, Wrocław University of Technology)
  • 2018 - D.Sc. (Faculty of Chemistry, Wrocław University of Science and Technology)


  • 2006 - Research Assistant (Faculty of Chemistry, Wrocław University of Technology)
  • 2009 - Assistant Professor (Faculty of Chemistry, Wrocław University of Technology)
  • 2020 - Associate Professor (Faculty of Chemistry, Wrocław University of Science and Technology)

Fellowships and scientific visits

  • 01.07- 30.09.2002- Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University (Belgium), Prof. Christian V. Stevens,
  • 01.07- 30.09.2003- Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University (Belgium), Prof. Christian V. Stevens,
  • 14.01- 14.04.2008- Institute of Organic Chemistry Polish Academy of Science in Warsaw, Poland, prof. Janusz Jurczak,
  • 01.10.2009-31.12.2010 Institute of Organic Chemistry, RWTH Aachen University, Germany, prof. Carsten Bolm

Teaching experience

Organic chemistry (lectures, seminars and laboratories), synthetic methods in organic synthesis, physical organic chemistry.

Research interests

  • Asymmetric catalysis
  • Hydrogen bonding
  • Mechanochemistry (ball milling in stereoselective synthesis)
  • Unorthodox interactions in organocatalysis (cation-π, anion-π interactions, halogen and chalcogen-bonding)


  1. Mała, Ż. A.; Janicki, M. J.; Niedźwiecka, N. H.; Góra, R. W.; Konieczny, K. A.; Kowalczyk, R., Stereoselectivity Enhancement During the Generation of Three Contiguous Stereocenters in Tetrahydrothiophenes ChemCatChem 2021, 13, 574. View at Publisher
  2. Dajek, M.; Pruszczyńska, A.; Konieczny, K. A.; Kowalczyk, R., Cinchona squaramide-catalyzed intermolecular desymmetrization of 1,3-diketones leading to chiral 1,4-dihydropyridines. Adv. Synth. Catal. 2020, 362, 3613. View at Publisher
  3. Ignatiuk, Z. A.; Janicki, M. J.; Gora, R. W.; Konieczny, K.; Kowalczyk, R. , Applications of Thermal Activation, Ball-milling and Aqueous Medium in Stereoselective Michael Addition of Nitromethane to Enynones Catalyzed by Chiral Squaramides Advanced Synthesis & Catalysis 2019, 361, 1108. View at Publisher
  4. Boratynski, P.J.; Galezowska, J.; Turkowiak, K.; Anisiewicz, A.; Kowalczyk, R .; Wietrzyk, J., Triazole Biheterocycles from Cinchona Alkaloids: Coordination and Antiproliferative Properties CHEMISTRYSELECT 2018, 3, 9368. View at Publisher
  5. Dajek, M.; Kowalczyk, R.; Boratynski, P. J. , trans-1,2-Diaminocyclohexane-based sulfonamides as effective hydrogen-bonding organocatalysts for asymmetric Michael-hemiacetalization reaction Catalysis Science & Technology 2018, 8, 4358. View at Publisher
  6. Galezowska, J. ; Boratynski, P.J.; Kowalczyk, R.; Lipke, K. ; Czapor-Irzabek, H., Copper(II) complexes of chiral 1,2,3-triazole biheterocyclic 'click' ligands equipped in Cinchona alkaloid moiety POLYHEDRON 2017, 121, 1. View at Publisher
  7. Macegoniuk, K.; Kowalczyk, R.; Rudzinska, A.; Psurski, M.; Wietrzyk, J.; Berlicki, L. , Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2017, 27, 1346. View at Publisher
  8. Przydacz, A.; Kowalczyk, R.; Albrecht, L. , Bronsted-base-catalyzed remote cascade reactivity of 2,4-dienones - asymmetric synthesis of tetrahydrothiophenes ORGANIC & BIOMOLECULAR CHEMISTRY 2017, 15, 9566. View at Publisher
  9. Boratynski, P.J. ; Kowalczyk, R., Click-Dimerized Cinchona Alkaloids JOURNAL OF ORGANIC CHEMISTRY 2016, 81, 8029. View at Publisher
  10. Boratynski, P.J.; Kowalczyk, R.; Kobylanska, A.; Bakowicz, J., Tricyclic Quaternary Ammonium Salts Derived from Cinchona Alkaloids JOURNAL OF ORGANIC CHEMISTRY 2016, 81, 12489. View at Publisher
  11. Kowalczyk, R.; Boratynski, P.J. , Stereoselective thia-Michael 1,4-Addition to Acyclic 2,4-Dienones and 2-En-4-ynones ADVANCED SYNTHESIS & CATALYSIS 2016, 358, 1289. View at Publisher
  12. Kowalczyk, R.; Wierzba, A.J.; Boratyński, P.J.; Bąkowicz, J., Site and stereoselectivity in sulfa-Michael addition to equivocally activated conjugated dienes RSC Advances 2015, 5, 66681. View at Publisher
  13. Kowalczyk, R.; Wierzba, A.J.; Boratyński, P.J.; Bąkowicz, J., Enantioselective conjugate addition of aliphatic thiols to divergently activated electron poor alkenes and dienes TETRAHEDRON 2014, 70, 5834. View at Publisher
  14. Bizet, V.; Kowalczyk, R.; Bolm, C., Fluorinated sulfoximines: syntheses, properties and applications Chemical Society Reviews 2014, 43, 2426. View at Publisher
  15. Kowalczyk, R.; Nowak, A.E.; Skarżewski, J., Organocatalytic asymmetric addition of aliphatic thiols to nitro olefins and nitrodienes Tetrahedron: Asymmetry 2013, 24, 505. View at Publisher
  16. Miyasaka, M.; Hirano, K.; Satoh, T.; Kowalczyk, R.; Bolm, C.; Miura, M., Copper-Catalyzed Direct Sulfoximination of Azoles and Polyfluoroarenes under Ambient Conditions Organic Letters 2011, 13, 359. View at Publisher
  17. Kowalczyk, R.; Edmunds, A.J.F.; Hall, R.G.; Bolm, C., Synthesis of CF3-Substituted Sulfoximines from Sulfonimidoyl Fluorides Organic Letters 2011, 13, 768. View at Publisher
  18. Chaładaj, W.; Kowalczyk, R.; Jurczak, J., Enantioselective Construction of Cis-2,6-Disubstituted Dihydropyrans: Total Synthesis of (-)-Centrolobine Journal of Organic Chemistry 2010, 75, 1740. View at Publisher
  19. Kowalczyk, R.; Skarzewski, J., Asymmetric nitroaldol reaction catalyzed by copper-diamine complexes: selective construction of two contiguous stereogenic centers Tetrahedron: Asymmetry 2009, 20, 2467. View at Publisher
  20. Kowalczyk, R.; Kwiatkowski, P.; Skarżewski, J.; Jurczak, J., Enantioselective Nitroaldol Reaction Catalyzed by Sterically Modified Salen Chromium Complexes Journal of Organic Chemistry 2009, 74, 753. View at Publisher