Scientific interests of the Department of Bioorganic Chemistry:
- Design (including computer-aided), synthesis and evaluation of organophosphonate inhibitors of chosen enzymes in hope that this will provide new drugs or agrochemicals:
- leucine aminopeptidase
- glutamine synthetase inhibitors|glutamine synthetase
- cathepsin C inhibitors|cathepsin C
- pyrroline-5-carboxylate reductase
- Synthesis of bisphosphonic acids as potential antiosteoporetic and antimalarial agents and/or herbicides.
- Stereoselective synthesis of aminophosphonates, and their short phosphono- and phosphinopeptides
- Organophosphorus compounds enantiodiscrimination.
- Application of enzymes and whole cells for preparation of enantiomerically pure hydroxy- and aminophosphonates.
- Aminophosphopnate and boronate units as components of chemoreceptors.
- Studies on mechanisms of degradation of carbon-to-phosphorus bond by bacteria, cyanobacteria and fungi.
- Utilization of popular component of Polish turpentine – carene – as a substrate for the synthesis of drugs and perfumes.
- Chemoenzymatic synthesis of new fragrances
- Immobilization of enzymes for laboratory and industrial purporses.
- Kinetic studies in process biocatalysis.
- Construction of diagnostic tools basing on libraries of enzyme effectors.
- Structural and conformational studies of dehydropeptides.
- peptide foldamers