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Scientific interests of the Department of Bioorganic Chemistry:

  • Design (including computer-aided), synthesis and evaluation of organophosphonate inhibitors of chosen enzymes in hope that this will provide new drugs or agrochemicals:
    • leucine aminopeptidase
    • glutamine synthetase inhibitors|glutamine synthetase
    • cathepsin C inhibitors|cathepsin C
    • pyrroline-5-carboxylate reductase
    • urease
  • Synthesis of bisphosphonic acids as potential antiosteoporetic and antimalarial agents and/or herbicides.
  • Stereoselective synthesis of aminophosphonates, and their short phosphono- and phosphinopeptides
  • Organophosphorus compounds enantiodiscrimination.
  • Application of enzymes and whole cells for preparation of enantiomerically pure hydroxy- and aminophosphonates.
  • Aminophosphopnate and boronate units as components of chemoreceptors.
  • Studies on mechanisms of degradation of carbon-to-phosphorus bond by bacteria, cyanobacteria and fungi.
  • Utilization of popular component of Polish turpentine – carene – as a substrate for the synthesis of drugs and perfumes.
  • Chemoenzymatic synthesis of new fragrances
  • Immobilization of enzymes for laboratory and industrial purporses.
  • Kinetic studies in process biocatalysis.
  • Construction of diagnostic tools basing on libraries of enzyme effectors.
  • Structural and conformational studies of dehydropeptides.
  • peptide foldamers