Wioletta Rut

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Born: 5.09.1989, Przeworsk

Hobby: volleyball, swimming

e-mail: wioletta.rut@pwr.wroc.pl

Phone: (+48) 71 320 2455


Master of Science, 2013, Wroclaw University of Technology, Poland, “Determination of legumain substrate specificity using fluorogenic substrates” supervisor: Ph.D. Marcin Drag


  1. Rut W, Zhang L, Kasperkiewicz P, Poreba M, Hilgenfeld R, Drag M, Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease Antiviral Research 2017, 139, 88. View at Publisher
  2. Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M, Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families Scientific Reports 2017, 7, 43135. View at Publisher
  3. Lunde NN, Haugen MH, Bodin Larsen KB, Damgaard I, Pettersen SJ, Kasem R, Rut W, Drag M, Poreba M, Johansen HT, Solberg R, Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions Biochimie 2017, 139, 27. View at Publisher
  4. Modak, J. K.; Rut, W.; Wijeyewickrema, L. C.; Pike, R. N.; Drąg, M.; Roujeinkova, A., Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase Biochimie 2016, 121, 60. View at Publisher
  5. Rut, W.; Drąg, M., Human 20S proteasome activity towards fluorogenic peptides of various chain lengths Biol. Chem. 2016, 396, 921. View at Publisher
  6. Drinkwater N, Sivaraman KK, Bamert RS, Rut W, Mohamed K, Vinh NB, Scammells PJ, Drag M, McGowan S, Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum Biochemical Journal 2016, 473, 3189. View at Publisher
  7. Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M., Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes Cell Chemical Biology 2016, 23, 1023. View at Publisher
  8. Rut, W.; Kasperkiewicz, P.; Byzia, A.; Poreba, M.; Groborz, K.; Drag, M., Recent advances and concepts in substrate specificity determination of proteases using tailored libraries of fluorogenic substrates with unnatural amino acids Biol. Chem. 2015, 396, 329. View at Publisher
  9. Bekes, M.; Rut, W.; Kasperkiewicz, P. Mulder, M. P.; Ovaa, H.; Drag, M.; Lima, C. D.; Huang, T. T., SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme. Biochem. J. 2015, 468, 215. View at Publisher
  10. Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M, Small Molecule Active Site Directed Tools for Studying Human Caspases Chemical Reviews 2015, 115, 12546. View at Publisher

Publications (in polish)

  1. Rut W, Charakterystyka ludzkiej legumainy – przegląd, Nowe trendy w naukach przyrodniczych – monografie. 2013, tom I, 4

Conference Communications

  1. Stróżyk A, Poreba M, Rut W, Kasperkiewicz P, Snipas S, Salvesen GS, Overall Ch, Mihelic M, Turk D, Drag M, “New and sesitive donor/acceptor pair for internally quenched fluorescent peptide substrates of proteases", 22 Polish Peptide Symposium, Kudowa Zdrój 1-5.09.2013.
  2. Drag M, Poreba M, Rut W, Kasperkiewicz P, Snipas S, Salvesen GS, ”Hybride combinatorial substrate libraries for profiling endoproteases substrate specificity”, Pacific Coast Protease Spring School, Miracle Springs Resort & Spa, Desert Hot Springs, California, USA April 28 – May 1, 2013.
  3. Rut W, Poreba M, Drag M, Turk B, “Kombinatoryczna biblioteka substratów fluorogenicznych do badania specyficzności substratowej ludzkiej legumainy“, Wpływ młodych naukowców na osiągnięcia polskiej nauki, Gdańsk 12.04.2013.