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Department of Bioorganic Chemistry is one of 15 departments of Faculty of Chemistry, Wrocław University of Technology. It was founded in 1971 by Professor Przemysław Mastalerz in response to introduction of biochemistry and biotechnology curricula at Faculty of Chemistry. Now it is headed by Professor Paweł Kafarski and formed by 6 professors, 10 assistant professors and over 25 PhD students doing research on a border of chemistry and biology.


Members

Research

Publications


News

Open positions for PhD student and Postdoc to work at project "Foldameric miniproteins - structure and catalytic function".

Konkurs na stypendium dla doktoranta oraz na stanowisko asystenta naukowego do pracy przy projekcie "Minibiałka forldamerowe - struktura i funkcja katalityczna".


Recent papers

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions
Lunde NN, Haugen MH, Bodin Larsen KB, Damgaard I, Pettersen SJ, Kasem R, Rut W, Drag M, Poreba M, Johansen HT, Solberg R
Biochimie 2017, 139, 27
DOI: 10.1016/j.biochi.2017.05.009

Recent papers

Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death
Poreba M, Salvesen GS
Cell Chemical Biology 2017, 24, 550
DOI: 10.1016/j.chembiol.2017.05.001

Recent papers

The application of organophosphorus flame-retardants in epoxy resin
A. Bereska, P. Kafarski, B, Bereska, B. Tkacz, J. Iłowska, J. Lenza
J. Vinyl. Addit. Technol. 2017, 21, 142
DOI: 10.1002/vnl.21492

Abstract
The influence of two novel aryl phosphate mixtures on fire retardancy and the thermal stability of epoxy resin were studied. Combustion behavior, decomposition pathway, and thermal and thermo-oxidative degradation of the epoxy resin were examined by using the limiting oxygen index, vertical burning test (UL-94), cone calorimeter test, thermogravimetric analysis, and thermogravimetry coupled with Fourier-transform infrared spectroscopy. The morphology of the residues from the degradation of flame-retarded epoxy resins was investigated by using scanning electron microscopy. Data from the cone calorimeter test demonstrated that the total heat evolved, heat release rate, and peak heat release rate decreased significantly when the epoxy resin contained these retardants. Moreover, a 20 wt% of both phosphate mixtures in the epoxy resin allowed for a satisfactory oxygen index (30–33%) and for UL-94 V2 to be achieved. The condensed-phase and gas-phase actions of these aryl phosphate flame-retardants are proposed as the mode of flame-retardancy in epoxy resins.

Recent papers

Kinetics of photochemical isomerization of TFA-Gly-ZΔPhe into TFA-Gly-EΔPhe
M. Makowski, M. Jewgiński, J. Hurek, A. Poliwoda, P. Kafarski
ARKIVOC 2017, 4, 88
DOI: 10.3998/ark.5550190.p009.936

Abstract
The kinetics of photoisomerization of trifluoroacetyl(Z)-dehydrophenylalanylglycine into trifluoroacetyl(E)-dehydrophenylalanylglycine was studied in the hope that light-induced reaction could be useful as a means of preparation of the E-dehydropeptides. The obtained results indicate that if this reaction carried out under irradiation with light ofwavelength of 360 nm it is practically irreversible and gave nearly quantitatively pure E-isomer Significantly, expected cyclic side-products were not observed in the reaction mixture, thus proving the preparative potential of the elaborated procedure.

Recent papers

Biochemistry - Knowledge to Practical Applications - Examples
Ewa Żymańczyk-Duda, Małgorzata Brzezińska-Rodak, Magdalena Klimek-Ochab, Maciej Duda
Biochemstry ISBN: 978-0-9971499-2-0 2017, 1

Recent papers

Enantio convergent biotransformation of O,O-dimethyl-4-oxoazetidin-2-ylphosphonate using fungal cells of Penicillium minioluteum and purified enzymes.
Kmiecik Natalia, Żymańczyk-Duda Ewa
Bioorganic Chemistry 2017, 71, 81

Recent papers

Microbial bioconversions of biologically active P-C compounds: scope and limitations of scaling-up.
Żymańczyk-Duda Ewa
Journal of Biotechnology and Biomaterials 2017, 7, 49

Recent papers

Reductive activity of free and immobilized cells of cyanobacteria toward oxophosphonates - comparative study.
Górak Monika, Żymańczyk-Duda Ewa
Journal of Applied Phycology 2017, 29, 245

Recent papers

Biodegradation of the aminopolyphosphonate DTPMP by the cyanobacterium Anabaena variabilis proceeds via a C–P lyase-independent pathway
Drzyzga, D.; Forlani, G.; Vermander, J.; Kafarski, P.; Lipok, J.
Environm. Microbiol. 2017, 19, 1065
DOI: 10.1111/1462-2920.13616

Abstract
Cyanobacteria, the only prokaryotes capable of oxygenic photosynthesis, play a major role in carbon, nitrogen and phosphorus global cycling. Under conditions of increased P availability and nutrient loading, some cyanobacteria are capable of blooming, rapidly multiplying and possibly altering the ecological structure of the ecosystem. Because of their ability of using non-conventional P sources,these microalgae can be used for bioremediation purposes. Under this perspective, the metabolization of the polyphosphonate diethylenetriaminepenta(methylenephosphonic) acid (DTPMP) by the strain CCALA 007 of Anabaena variabilis was investigated using 31P NMR analysis. Results showed a quantitative breakdown of DTPMP by cell-free extracts from cyanobacterial cells grown in the absence of any phosphonate. The identification of intermediates and products allowed us to propose a unique and new biodegradation pathway in which the formation of (N-acetylaminomethyphosphonic acid represents a key step. This hypothesis was strengthened by the results obtained by incubating cell-free extracts with pathway intermediates. When Anabaena cultures were grown in the presence of the phosphonate, or phosphorus-starved before the extraction, signifi cantly higher biodegradation rates were found.

Recent papers

Metabolomics analysis of fungal biofilm development and of arachidonic acid-based quorum sensing mechanism
Ząbek A, Junka A, Szymczyk P, Wojtowicz W, Klimek-Ochab M, Młynarz P
Journal of Basic Microbiology 2017, 9999, 1
DOI: 10.1002/jobm.201600636