Rafał Latajka
From Bioorganic
Born: January 24, 1972, Wrocław, Poland
Status: married, two sons
Hobby: cooking, history, sport – supporter of WKS Śląsk Wrocław
Address:
Department of Bioorganic Chemistry,
Faculty of Chemistry,
Wroclaw University of Science and Technology,
Wybrzeże Wyspianskiego 27,
50-370 Wroclaw, Poland
Tel: 0048 71 320 2463, Fax: 0048 71 320 2427
e-mail: rafal.latajka@pwr.edu.pl
Education
- 2009 — Faculty of Chemistry, Wrocław University of Technology, habilitation in Chemistry.
- 2001 — Faculty of Chemistry, Wrocław University of Technology, PhD in Chemistry, supervisor: Prof. Paweł Kafarski.
- 1996 — Faculty of Chemistry, University of Wrocław, MSc in Chemistry, supervisor: Prof. Henryk Kozłowski.
Employment
- 2013 – Associate Professor, Department of Bioorganic Chemistry, Wrocław University of Technology.
- 2001 – Assistant Professor, Department of Bioorganic Chemistry, Wrocław University of Technology.
- 1997 – PhD. student, Department of Bioorganic Chemistry, Wroclaw University of Technology.
Fellowships and scientific visits
- Germany, University of Bielefeld, Department of Chemistry, Group of Prof. Norbert Sewald, DAAD Fellowship, 2009 (3 weeks);
- Germany, University of Bielefeld, Department of Chemistry, Group of Prof. Norbert Sewald, DAAD Fellowship, 2008 (2 weeks);
- Italy, University of Naples “Federico II”, Department of Chemistry, Department of Bioinorganic Chemistry, Postdoctoral Marie Curie Fellowship, 2003 (12 months);
- Poland, Adam Mickiewicz University, Poznań, Department of Chemistry, Prof. Henryk Koroniak Group, Fellowship of Foundation of Polish Science, 2002 (3 months).
Research interests
- Design of novel, low-molecular weight enzyme inhibitors.
- Synthesis and activity of antifreezing glycopeptides (AFGP),
- Application of NMR spectroscopy to structure-activity relationship studies,
- Design, structure and application of peptidomimetics and peptidic foldamers.
International research co-operations
- Prof. Norbert Sewald, University of Bielefeld, Germany.
- Prof. Iris Antes, Technical University of Munich, Germany
- Prof. Anna Maria Papini, University of Florence, Italy
- Prof. Paolo Rovero, University of Florence, Italy
- Prof. Francisco Garcia Canovas, University of Murcia, Spain
Professional memberships and functions
- Head of PhD studies at Faculty of Chemistry (2020 - 2023)
- Dean's Plenipotentiary for People with Disabilities (2020 - 2024)
- Polish Chemical Society (since 1992)
- European Peptide Society (since 2002)
- Member of the main board of Polish Chemical Society (2016 – 2018 and 2019 - 2021)
- I Vice-president of Polish Chemical Society (2019-2021)
Awards
- 2001 - Award of Dean of Faculty of Chemistry, Wroclaw University of Technology.
- 2010 - Award of Rector of Wroclaw University of Technology
- 2015 - Award of Rector of Wroclaw University of Technology
Publications
- Hałdys, K.; Goldeman, W.; Anger-Góra, N.; Rossowska, J.; Latajka, R., Monosubstituted Acetophenone Thiosemicarbazones as Potent Inhibitors of Tyrosinase: Synthesis, Inhibitory Studies, and Molecular Docking. Pharmaceuticals 2021, 14, 74. View at Publisher
- Ledwon, P.; Errante, F.; Papini, A. M.; Rovero, P.; Latajka, R., Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry. Chem. Biodiversity 2021, accepted.
- Hałdys K., Goldeman W., Jewgiński M., Wolińska E., Anger-Góra N., Rossowska J., Latajka R., Halogenated aromatic thiosemicarbazones as potent inhibitors of tyrosinase and melanogenesis Bioorganic Chemistry 2020, 94, 103419. View at Publisher
- Errante F.; Ledwoń P.; Latajka R.; Rovero P.; Papini A.M., Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy Frontiers in Chemistry 2020, 8, 572923. View at Publisher
- Katarzyna Hałdys, Rafał Latajka, Thiosemicarbazones with tyrosinase inhibitory activity MedChemComm 2019, 10, 378. View at Publisher
- Schröder D.C., Kracker O., Fröhr T., Góra J., Jewginski M., Nieß A., Antes I., Latajka R., Marion A., Sewald N., 1,4-Disubstituted 1H-1,2,3-Triazole Containing Peptidotriazolamers: A New Class of Peptidomimetics With Interesting Foldamer Properties Frontiers in Chemistry 2019, 7, 1. View at Publisher
- Wolinska, E.; Hałdys, K.; Góra, J.; Olszewski, T.K.; Boduszek, B.; Latajka, R., Phosphonic and phosphinic acid derivatives as novel tyrosinaseinhibitors: Kinetic studies and molecular docking. Chem. Biodiversity 2019, 1. View at Publisher
- Urbańczyk M., Jewgiński M, Krzciuk-Gula J., Góra J., Latajka R., Sewald N., Synthesis and conformational preferences of short analogues of antifreeze glycopeptides (AFGP) Beilstein J. Org. Chem. 2019, 15, 1581. View at Publisher
- Hałdys, K.; Goldeman, W.; Jewgiński, M.; Wolińska, E.; Anger, N.; Rossowska, J.; Latajka, R.;, Inhibitory properties of aromatic thiosemicarbazones on mushroom tyrosinase: Synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis inhibition. Bioorg. Chem. 2018, 81, 577. View at Publisher
- Malik-Gajewska, M.; Trynda, J.; Zierkiewicz, W.; Helios, K.; Latajka, R.; Wietrzyk, J.; Michalska, D., Picoplatin-based complexes with the bioactive orotate and 5-fluoroorotate ligands: Synthesis, DFT calculations, structure, spectroscopic characterization and in vitro cytotoxicity. J. Mol. Struct. 2018, 1171, 155.
- Kracker, O.; Góra, J.; Krzciuk-Gula, J.; Marion, A.; Neumann, B.; Stammler, H-G.; Niess, A.; Antes, I.; Latajka, R.; Sewald, N., 1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics. Chem. Eur. J. 2018, 24, 953.
- Marion, A.; Gora, J.; Kracker, O.; Frohr, T.; Latajka, R.; Sewald, N.; Antes, I., Amber-Compatible Parametrization Procedure for Peptide-like Compounds: Application to 1,4- and 1,5-Substituted Triazole-Based Peptidomimetics. J. Chem. Inf. Model. 2018, 58, 90.
- Lenartowicz, P.; Makowski, M.; Oszywa, B.; Haremza, K.; Latajka, R.; Pawełczak, M.; Kafarski, P., Addition of thiols to the double bond of dipeptide C -terminal dehydroalanine as a source of new inhibitors of cathepsin C Biochimie 2017, 139, 46. View at Publisher
- Urbańczyk, M.; Góra, J.; Latajka, R.; Sewald, N., Antifreeze glycopeptides: from structure and activity studies to current approaches in chemical synthesis. Amino Acids 2017, 49, 209.
- Lamch, Ł.; Tylus, W.; Jewgiński, M.; Latajka, R.; Wilk, K.A., Location of Varying Hydrophobicity Zinc(II) Phthalocyanine-Type Photosensitizers in Methoxy Poly(ethylene oxide) and Poly(L‑lactide) Block Copolymer Micelles Using 1H NMR and XPS Techniques. J. Phys. Chem. B 2016, 120, 12768.
- Góra, J.; Latajka, R., Involvement of Cysteine Proteases in Cancer. Curr. Med. Chem. 2015, 22, 944.
- Buczek A, Makowski M, Jewginski M, Latajka R, Kupka T, Broda M, Toward Engineering Efficient Peptidomimetics. Screening Conformational Landscape of Two Modified Dehydroaminoacids Biopolymers 2014, 101, 28.
- Poręba, M.; Mihelic, M.; Krai, P.; Rajkovic, J.; Krężel, A.; Pawełczak, M.; Klemba, M.; Turk, D.; Turk, B.; Latajka, R.; Drąg, M., Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C. Amino Acids 2014, 46, 931. View at Publisher
- Jewgiński, M; Krzciuk-Gula, J.; Makowski, M.; Latajka, R. Kafarski P., Conformation of dehydropentapeptides containing four achiral amino acid residues – controlling the role of L-valine Beilstein J. Org. Chem. 2014, 10, 660. View at Publisher
- Dudka, I.; Kossowska, B.; Senhadri, H.; Latajka, R.; Hajek, J.; Andrzejak, R.; Antonowicz-Juchniewicz, J.; Gancarz, R., Metabonomic analysis of serum of workers occupationally exposed to arsenic, cadmium and lead for biomarker research: A preliminary study. Environment International 2014, 68, 71. View at Publisher
- Jewgiński, M.; Latajka, R.; Krężel, A.; Haremza, K.; Makowski, M.; Kafarski, P., Influence of solvents on conformation of dehydropeptides J. Mol. Struct. 2013, 1035, 129. View at Publisher
- Pluskota-Karwatka, D. ; Pawłowicz, A. J.; Bruszyńska, M.; Greszkiewicz, A.; Latajka, R.; Kronberg, L., Identification of Adducts Formed in the Reactions of Malonaldehyde – glyoxal and Malonaldehyde – methylglyoxal with Adenosine and Calf Thymus DNA Chemistry & Biodiversity 2010, 7, 959.
- Lisowski M., Jaremko Ł., Jaremko M., Mazur A., Latajka R., Makowski M. , Effect of the dPhe residue configuration on a didehydropeptides conformation: a combined CD and NMR study Biopolymers 2010, 93, 1055.
- Latajka, R.; Krężel, A.; Mucha, A.; Jewgiński, M.; Kafarski, P., Conformational investigations of bis(alpha-aminoalkyl)phosphinic acids and studies of the stability of their complexes with Cu(II). J. Mol. Str. 2008, 877, 64.
- Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Klimek-Ochab, M.; Latajka, R.; Kafarski, P.; Lejczak, B., Chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethylphosphonate as a valuable product of microbial biotransformation of diethyl 2-oxo-2-phenylethylphosphonate J. Mol. Cat. B 2008, 52, 74.
- Lisowski, M.; Latajka, R.; Picur, B.; Lis, T.; Bryndal, I.; Rospenk, M.; Makowski, M.; Kafarski, P., Combined effect of the dehydro-Phe or dehydro-Ala residue and the p-nitroanilide group on a dehydropeptides conformation Biopolymers 2008, 89, 220.
- Latajka, R.; Jewgiński, M.; Makowski, M.; Krężel, A.; Paluch, S., Conformational studies of hexapeptides containing two dehydroamino acid residues in positon 2 and 5 in peptide chain Biopolymers 2008, 89, 691.
- Latajka, R.; Jewginski, M.; Makowski, M., Pawełczak, M.; Huber, T.; Sewald, N.; Kafarski, P., Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C J. Pept. Sci. 2008, 14, 1084. View at Publisher
- Latajka, R.; Jewgiński, M.; Makowski, M.; Krężel, A.;, Conformational studies of hexapeptides containing two dehydroamino acid residues in positon 3 and 5 in peptide chain J. Mol. Struct. 2008, 1.
- Młynarz, P.; Jewgiński, M.; Sliwinska, S.; Latajka, R.; Schroeder, G.; Kafarski, P., Twin phosphorous atoms of tetraethyl 2-methyl-piperyd-1-ylmethylenebisphosphonates Heteroatom Chem. 2007, 18, 774. View at Publisher
- Latajka, R.; Makowski, M.; Jewginski, M.; Pawelczak, M.; Koroniak, H.; Kafarski, P., Peptide p-nitrophenylanilides containing (E)-dehydrophenylalanine - synthesis, structural studies and evaluation of their activity towards cathepsin C. New J. Chem. 2006, 30, 1009. View at Publisher
- Frackowiak, B.; Olejniczak, T.; Latajka, R.; Bialonska, A.; Ciunik, Z.; Lochynski, S. , Stereochemistry of terpene derivatives. Part 4: Fragrant terpenoid derivatives with an unsaturated gem-dimethylbicyclo[3.1.0]hexane system. Tetrahedron: Asymmetry 2005, 16, 3352.
- Gumienna-Kontecka, E.; Galezowska, J.; Drag, M.; Latajka, R.; Kafarski, P.; Kozlowski, H., Coordination abilities of substituted beta-aminophosphonates towards Cu2+ and Zn2+ ions. Inorganica Chimica Acta 2004, 357, 1632. View at Publisher
- Zon, J.; Szefczyk, B.; Sawka-Dobrowolska, W.; Gancarz, R.; Kucharska-Zon, M.; Latajka, R.; Amrhein, N.; Miziak, P.; Szczepanik, W., Experimental and ab initio calculated structures of 2-aminoindane-2-phosphonic acid, a potent inhibitor of phenylalanine ammonia-lyase, and theoretical studies of its binding to the model enzyme structure. New J. Chem. 2004, 28, 1048.
- Drag, M.; Latajka, R.; Gumienna-Kontecka, E.; Kozlowski, H.; Kafarski, P. , Stereoselective synthesis, solution structure and metal complexes of (1S,2S)-2-amino-1-hydroxyalkylphosphonic acids. Tetrahedron-Asymmetry 2003, 14, 1837. View at Publisher
- Krężel, A.; Latajka, R.; Bujacz, G.D.; Bal, W. , Coordination properties of tris(2-carboxyethyl)phosphine, a newly introduced thiol reductant, and its oxide. Inorg. Chem. 2003, 42, 1994.
- Latajka, R.; Jewginski, M.; Pawelczak, M.; Makowski, M.; Kafarski, P., Conformational preferences and biological activity of short peptides containing (e)dehydrophenylalanine. Biopolymers 2003, 73, 301.
- Kilyen, M.; Lakatos, A.; Latajka, R.; Labadi, I.; Salifoglou, A.; Raptopoulou, C.P.; Kozlowski, H.; Kiss, T., Al(III)-binding properties of iminodiacetic acid, nitrilotriacetic acid and their mixed carboxylic-phosphonic derivatives. J. Chem. Soc. Dalton Trans. 2002, 3578.
- Drag, M.; Latajka, R.; Gancarz, R.; Kafarski, P.; Pirat, J.L.; Cristau, H.J. , Regio- and stereoselective synthesis, solution conformations of 2-amino-1-hydroxy-2-arylethylphosphonic esters and acids. Phosphrus, Sulfur, and Silicon, and Rel. Elem. 2002, 177, 2191. View at Publisher
- Latajka, R.; Gancarz, R.; Kafarski, P. , Slow inversion of stereoisomers of 4-amino-1-benzylpiperid-4-yl phosphonic acids and their esters. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2002, 177, 1575.
- Latajka, R.; Drag, M.; Gancarz, R.; Kafarski, P. , Solution conformations of 2-amino-1-hydroxy-2-aryl ethylphosphonic acids and their diethyl esters. J. Mol. Struct. 2002, 605, 79. View at Publisher
- Makowski, M.; Pawelczak, M.; Latajka, R.; Nowak, K.; Kafarski, P. , Synthesis of tetrapeptide p-nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activity. J. Pept. Sci. 2001, 7, 141.
- Boduszek, B.; Latajka, R.; Walkowiak, U. , Acid-catalyzed cleavage of some chromone, coumarin and pyrone derivatives of aminomethylphosphonic acid. Products and kinetics of the reaction. Pol. J. Chem. 2001, 75, 63.
- Boduszek, B.; Latajka, R.; Lesniak, W. , Acid-catalyzed cleavage of 2-pyridyl and 4-pyridyl derivatives of aminomethylphosphonic acid. Kinetic and chemical arguments for a mechanism with A-S(E)2 character. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2000, 165, 53.
- Gancarz, R.; Latajka, R.; Halama, A.; Kafarski, P. , Slow inversion of stereoisomers of cyclic GABA analogues. Magn. Res. Chem. 2000, 38, 867.
- Boduszek, B.; Halama, A.; Latajka, R. , A simple one-step synthesis of monoesters of aminophosphonic acids. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2000, 158, 141.
- Gancarz, R.; Latajka, R.; Maluszek, B.; Żymańczyk-Duda, E.; Kafarski, P. , Hydrogen bonding in diethyl 2-hydroxypropylphosphonate - an example of equilibrium between intramolecular and intermolecular bonding. Magn. Res. Chem. 2000, 38, 197.
- Bal, W.; Dyba, M.; Kasprzykowski, F.; Kozłowski, H.; Latajka, R.; Lankiewicz, L.; Mackiewicz, Z.; Pettit, L.D., How non-bonding amino acid side-chains may enormously increase the stability of a Cu(II)-peptide complex. Inorg. Chim. Acta 1998, 283, 1.