Rafał Latajka

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Born: January 24, 1972, Wrocław, Poland

Status: married, two sons

Hobby: cooking, history, sport – supporter of WKS Śląsk Wrocław

Address:

Department of Bioorganic Chemistry,

Faculty of Chemistry,

Wroclaw University of Science and Technology,

Wybrzeże Wyspianskiego 27,

50-370 Wroclaw, Poland

Tel: 0048 71 320 2463, Fax: 0048 71 320 2427

e-mail: rafal.latajka@pwr.edu.pl


Education

  • 2009 — Faculty of Chemistry, Wrocław University of Technology, habilitation in Chemistry.
  • 2001 — Faculty of Chemistry, Wrocław University of Technology, PhD in Chemistry, supervisor: Prof. Paweł Kafarski.
  • 1996 — Faculty of Chemistry, University of Wrocław, MSc in Chemistry, supervisor: Prof. Henryk Kozłowski.

Employment

  • 2013 – Associate Professor, Department of Bioorganic Chemistry, Wrocław University of Technology.
  • 2001 – Assistant Professor, Department of Bioorganic Chemistry, Wrocław University of Technology.
  • 1997 – PhD. student, Department of Bioorganic Chemistry, Wroclaw University of Technology.

Fellowships and scientific visits

  • Germany, University of Bielefeld, Department of Chemistry, Group of Prof. Norbert Sewald, DAAD Fellowship, 2009 (3 weeks);
  • Germany, University of Bielefeld, Department of Chemistry, Group of Prof. Norbert Sewald, DAAD Fellowship, 2008 (2 weeks);
  • Italy, University of Naples “Federico II”, Department of Chemistry, Department of Bioinorganic Chemistry, Postdoctoral Marie Curie Fellowship, 2003 (12 months);
  • Poland, Adam Mickiewicz University, Poznań, Department of Chemistry, Prof. Henryk Koroniak Group, Fellowship of Foundation of Polish Science, 2002 (3 months).

Research interests

  • Design of novel, low-molecular weight enzyme inhibitors.
  • Synthesis and activity of antifreezing glycopeptides (AFGP),
  • Application of NMR spectroscopy to structure-activity relationship studies,
  • Design, structure and application of peptidomimetics and peptidic foldamers.

International research co-operations

  • Prof. Norbert Sewald, University of Bielefeld, Germany.
  • Prof. Iris Antes, Technical University of Munich, Germany
  • Prof. Anna Maria Papini, University of Florence, Italy
  • Prof. Paolo Rovero, University of Florence, Italy
  • Prof. Francisco Garcia Canovas, University of Murcia, Spain

Professional memberships and functions

  • Head of PhD studies at Faculty of Chemistry (2020 - 2023)
  • Dean's Plenipotentiary for People with Disabilities (2020 - 2024)
  • Polish Chemical Society (since 1992)
  • European Peptide Society (since 2002)
  • Member of the main board of Polish Chemical Society (2016 – 2018 and 2019 - 2021)
  • I Vice-president of Polish Chemical Society (2019-2021)

Awards

  • 2001 - Award of Dean of Faculty of Chemistry, Wroclaw University of Technology.
  • 2010 - Award of Rector of Wroclaw University of Technology
  • 2015 - Award of Rector of Wroclaw University of Technology


Publications

  1. Hałdys K., Goldeman W., Jewgiński M., Wolińska E., Anger-Góra N., Rossowska J., Latajka R., Halogenated aromatic thiosemicarbazones as potent inhibitors of tyrosinase and melanogenesis Bioorganic Chemistry 2020, 94, 103419. View at Publisher
  2. Katarzyna Hałdys, Rafał Latajka, Thiosemicarbazones with tyrosinase inhibitory activity MedChemComm 2019, 10, 378. View at Publisher
  3. Schröder D.C., Kracker O., Fröhr T., Góra J., Jewginski M., Nieß A., Antes I., Latajka R., Marion A., Sewald N., 1,4-Disubstituted 1H-1,2,3-Triazole Containing Peptidotriazolamers: A New Class of Peptidomimetics With Interesting Foldamer Properties Frontiers in Chemistry 2019, 7, 1. View at Publisher
  4. Wolinska, E.; Hałdys, K.; Góra, J.; Olszewski, T.K.; Boduszek, B.; Latajka, R., Phosphonic and phosphinic acid derivatives as novel tyrosinaseinhibitors: Kinetic studies and molecular docking. Chem. Biodiversity 2019, 1. View at Publisher
  5. Urbańczyk M., Jewgiński M, Krzciuk-Gula J., Góra J., Latajka R., Sewald N., Synthesis and conformational preferences of short analogues of antifreeze glycopeptides (AFGP) Beilstein J. Org. Chem. 2019, 15, 1581. View at Publisher
  6. Hałdys, K.; Goldeman, W.; Jewgiński, M.; Wolińska, E.; Anger, N.; Rossowska, J.; Latajka, R.;, Inhibitory properties of aromatic thiosemicarbazones on mushroom tyrosinase: Synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis inhibition. Bioorg. Chem. 2018, 81, 577. View at Publisher
  7. Malik-Gajewska, M.; Trynda, J.; Zierkiewicz, W.; Helios, K.; Latajka, R.; Wietrzyk, J.; Michalska, D., Picoplatin-based complexes with the bioactive orotate and 5-fluoroorotate ligands: Synthesis, DFT calculations, structure, spectroscopic characterization and in vitro cytotoxicity. J. Mol. Struct. 2018, 1171, 155.
  8. Kracker, O.; Góra, J.; Krzciuk-Gula, J.; Marion, A.; Neumann, B.; Stammler, H-G.; Niess, A.; Antes, I.; Latajka, R.; Sewald, N., 1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics. Chem. Eur. J. 2018, 24, 953.
  9. Marion, A.; Gora, J.; Kracker, O.; Frohr, T.; Latajka, R.; Sewald, N.; Antes, I., Amber-Compatible Parametrization Procedure for Peptide-like Compounds: Application to 1,4- and 1,5-Substituted Triazole-Based Peptidomimetics. J. Chem. Inf. Model. 2018, 58, 90.
  10. Lenartowicz, P.; Makowski, M.; Oszywa, B.; Haremza, K.; Latajka, R.; Pawełczak, M.; Kafarski, P., Addition of thiols to the double bond of dipeptide C -terminal dehydroalanine as a source of new inhibitors of cathepsin C Biochimie 2017, 139, 46. View at Publisher
  11. Urbańczyk, M.; Góra, J.; Latajka, R.; Sewald, N., Antifreeze glycopeptides: from structure and activity studies to current approaches in chemical synthesis. Amino Acids 2017, 49, 209.
  12. Lamch, Ł.; Tylus, W.; Jewgiński, M.; Latajka, R.; Wilk, K.A., Location of Varying Hydrophobicity Zinc(II) Phthalocyanine-Type Photosensitizers in Methoxy Poly(ethylene oxide) and Poly(L‑lactide) Block Copolymer Micelles Using 1H NMR and XPS Techniques. J. Phys. Chem. B 2016, 120, 12768.
  13. Góra, J.; Latajka, R., Involvement of Cysteine Proteases in Cancer. Curr. Med. Chem. 2015, 22, 944.
  14. Buczek A, Makowski M, Jewginski M, Latajka R, Kupka T, Broda M, Toward Engineering Efficient Peptidomimetics. Screening Conformational Landscape of Two Modified Dehydroaminoacids Biopolymers 2014, 101, 28.
  15. Poręba, M.; Mihelic, M.; Krai, P.; Rajkovic, J.; Krężel, A.; Pawełczak, M.; Klemba, M.; Turk, D.; Turk, B.; Latajka, R.; Drąg, M., Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C. Amino Acids 2014, 46, 931. View at Publisher
  16. Jewgiński, M; Krzciuk-Gula, J.; Makowski, M.; Latajka, R. Kafarski P., Conformation of dehydropentapeptides containing four achiral amino acid residues – controlling the role of L-valine Beilstein J. Org. Chem. 2014, 10, 660. View at Publisher
  17. Dudka, I.; Kossowska, B.; Senhadri, H.; Latajka, R.; Hajek, J.; Andrzejak, R.; Antonowicz-Juchniewicz, J.; Gancarz, R., Metabonomic analysis of serum of workers occupationally exposed to arsenic, cadmium and lead for biomarker research: A preliminary study. Environment International 2014, 68, 71. View at Publisher
  18. Jewgiński, M.; Latajka, R.; Krężel, A.; Haremza, K.; Makowski, M.; Kafarski, P., Influence of solvents on conformation of dehydropeptides J. Mol. Struct. 2013, 1035, 129. View at Publisher
  19. Pluskota-Karwatka, D. ; Pawłowicz, A. J.; Bruszyńska, M.; Greszkiewicz, A.; Latajka, R.; Kronberg, L., Identification of Adducts Formed in the Reactions of Malonaldehyde – glyoxal and Malonaldehyde – methylglyoxal with Adenosine and Calf Thymus DNA Chemistry & Biodiversity 2010, 7, 959.
  20. Lisowski M., Jaremko Ł., Jaremko M., Mazur A., Latajka R., Makowski M. , Effect of the dPhe residue configuration on a didehydropeptides conformation: a combined CD and NMR study Biopolymers 2010, 93, 1055.
  21. Latajka, R.; Krężel, A.; Mucha, A.; Jewgiński, M.; Kafarski, P., Conformational investigations of bis(alpha-aminoalkyl)phosphinic acids and studies of the stability of their complexes with Cu(II). J. Mol. Str. 2008, 877, 64.
  22. Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Klimek-Ochab, M.; Latajka, R.; Kafarski, P.; Lejczak, B., Chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethylphosphonate as a valuable product of microbial biotransformation of diethyl 2-oxo-2-phenylethylphosphonate J. Mol. Cat. B 2008, 52, 74.
  23. Lisowski, M.; Latajka, R.; Picur, B.; Lis, T.; Bryndal, I.; Rospenk, M.; Makowski, M.; Kafarski, P., Combined effect of the dehydro-Phe or dehydro-Ala residue and the p-nitroanilide group on a dehydropeptides conformation Biopolymers 2008, 89, 220.
  24. Latajka, R.; Jewgiński, M.; Makowski, M.; Krężel, A.; Paluch, S., Conformational studies of hexapeptides containing two dehydroamino acid residues in positon 2 and 5 in peptide chain Biopolymers 2008, 89, 691.
  25. Latajka, R.; Jewginski, M.; Makowski, M., Pawełczak, M.; Huber, T.; Sewald, N.; Kafarski, P., Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C J. Pept. Sci. 2008, 14, 1084. View at Publisher
  26. Latajka, R.; Jewgiński, M.; Makowski, M.; Krężel, A.;, Conformational studies of hexapeptides containing two dehydroamino acid residues in positon 3 and 5 in peptide chain J. Mol. Struct. 2008, 1.
  27. Młynarz, P.; Jewgiński, M.; Sliwinska, S.; Latajka, R.; Schroeder, G.; Kafarski, P., Twin phosphorous atoms of tetraethyl 2-methyl-piperyd-1-ylmethylenebisphosphonates Heteroatom Chem. 2007, 18, 774. View at Publisher
  28. Latajka, R.; Makowski, M.; Jewginski, M.; Pawelczak, M.; Koroniak, H.; Kafarski, P., Peptide p-nitrophenylanilides containing (E)-dehydrophenylalanine - synthesis, structural studies and evaluation of their activity towards cathepsin C. New J. Chem. 2006, 30, 1009. View at Publisher
  29. Frackowiak, B.; Olejniczak, T.; Latajka, R.; Bialonska, A.; Ciunik, Z.; Lochynski, S. , Stereochemistry of terpene derivatives. Part 4: Fragrant terpenoid derivatives with an unsaturated gem-dimethylbicyclo[3.1.0]hexane system. Tetrahedron: Asymmetry 2005, 16, 3352.
  30. Gumienna-Kontecka, E.; Galezowska, J.; Drag, M.; Latajka, R.; Kafarski, P.; Kozlowski, H., Coordination abilities of substituted beta-aminophosphonates towards Cu2+ and Zn2+ ions. Inorganica Chimica Acta 2004, 357, 1632. View at Publisher
  31. Zon, J.; Szefczyk, B.; Sawka-Dobrowolska, W.; Gancarz, R.; Kucharska-Zon, M.; Latajka, R.; Amrhein, N.; Miziak, P.; Szczepanik, W., Experimental and ab initio calculated structures of 2-aminoindane-2-phosphonic acid, a potent inhibitor of phenylalanine ammonia-lyase, and theoretical studies of its binding to the model enzyme structure. New J. Chem. 2004, 28, 1048.
  32. Drag, M.; Latajka, R.; Gumienna-Kontecka, E.; Kozlowski, H.; Kafarski, P. , Stereoselective synthesis, solution structure and metal complexes of (1S,2S)-2-amino-1-hydroxyalkylphosphonic acids. Tetrahedron-Asymmetry 2003, 14, 1837. View at Publisher
  33. Krężel, A.; Latajka, R.; Bujacz, G.D.; Bal, W. , Coordination properties of tris(2-carboxyethyl)phosphine, a newly introduced thiol reductant, and its oxide. Inorg. Chem. 2003, 42, 1994.
  34. Latajka, R.; Jewginski, M.; Pawelczak, M.; Makowski, M.; Kafarski, P., Conformational preferences and biological activity of short peptides containing (e)dehydrophenylalanine. Biopolymers 2003, 73, 301.
  35. Kilyen, M.; Lakatos, A.; Latajka, R.; Labadi, I.; Salifoglou, A.; Raptopoulou, C.P.; Kozlowski, H.; Kiss, T., Al(III)-binding properties of iminodiacetic acid, nitrilotriacetic acid and their mixed carboxylic-phosphonic derivatives. J. Chem. Soc. Dalton Trans. 2002, 3578.
  36. Drag, M.; Latajka, R.; Gancarz, R.; Kafarski, P.; Pirat, J.L.; Cristau, H.J. , Regio- and stereoselective synthesis, solution conformations of 2-amino-1-hydroxy-2-arylethylphosphonic esters and acids. Phosphrus, Sulfur, and Silicon, and Rel. Elem. 2002, 177, 2191. View at Publisher
  37. Latajka, R.; Gancarz, R.; Kafarski, P. , Slow inversion of stereoisomers of 4-amino-1-benzylpiperid-4-yl phosphonic acids and their esters. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2002, 177, 1575.
  38. Latajka, R.; Drag, M.; Gancarz, R.; Kafarski, P. , Solution conformations of 2-amino-1-hydroxy-2-aryl ethylphosphonic acids and their diethyl esters. J. Mol. Struct. 2002, 605, 79. View at Publisher
  39. Makowski, M.; Pawelczak, M.; Latajka, R.; Nowak, K.; Kafarski, P. , Synthesis of tetrapeptide p-nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activity. J. Pept. Sci. 2001, 7, 141.
  40. Boduszek, B.; Latajka, R.; Walkowiak, U. , Acid-catalyzed cleavage of some chromone, coumarin and pyrone derivatives of aminomethylphosphonic acid. Products and kinetics of the reaction. Pol. J. Chem. 2001, 75, 63.
  41. Boduszek, B.; Latajka, R.; Lesniak, W. , Acid-catalyzed cleavage of 2-pyridyl and 4-pyridyl derivatives of aminomethylphosphonic acid. Kinetic and chemical arguments for a mechanism with A-S(E)2 character. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2000, 165, 53.
  42. Gancarz, R.; Latajka, R.; Halama, A.; Kafarski, P. , Slow inversion of stereoisomers of cyclic GABA analogues. Magn. Res. Chem. 2000, 38, 867.
  43. Boduszek, B.; Halama, A.; Latajka, R. , A simple one-step synthesis of monoesters of aminophosphonic acids. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2000, 158, 141.
  44. Gancarz, R.; Latajka, R.; Maluszek, B.; Żymańczyk-Duda, E.; Kafarski, P. , Hydrogen bonding in diethyl 2-hydroxypropylphosphonate - an example of equilibrium between intramolecular and intermolecular bonding. Magn. Res. Chem. 2000, 38, 197.
  45. Bal, W.; Dyba, M.; Kasprzykowski, F.; Kozłowski, H.; Latajka, R.; Lankiewicz, L.; Mackiewicz, Z.; Pettit, L.D., How non-bonding amino acid side-chains may enormously increase the stability of a Cu(II)-peptide complex. Inorg. Chim. Acta 1998, 283, 1.
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